2010
DOI: 10.1007/s12350-010-9240-4
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Molecular imaging with contrast enhanced ultrasound

Abstract: Noninvasive cardiovascular imaging techniques are well-established for studying cardiovascular anatomy and physiology. Over the past decade contrast enhanced imaging techniques have been developed that are also able to characterize the molecular constituents of cardiovascular disease. In this regard, microbubble- and ultrasound-based techniques have the ability to assess a broad range of molecular components of cardiovascular pathology such as inflammation, recent ischemia, atherosclerosis, acute transplant re… Show more

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Cited by 14 publications
(8 citation statements)
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“…The compressible nature of the gas core allows MCA's to scatter ultrasound (US) energy more effectively than surrounding blood and tissue, thus making them effective probes for vascular imaging. Currently, MCA's are used clinically to monitor blood perfusion in several organs (for a recent comprehensive review on clinical applications of microbubbles, see 2) and molecular targeting in preclinical studies 2-7 and clinical trials 8. MCA's, although typically used to enhance US contrast for imaging, are becoming increasingly popular for systemically targeting drugs and genes to malignant tissue 9, 10.…”
Section: Introductionmentioning
confidence: 99%
“…The compressible nature of the gas core allows MCA's to scatter ultrasound (US) energy more effectively than surrounding blood and tissue, thus making them effective probes for vascular imaging. Currently, MCA's are used clinically to monitor blood perfusion in several organs (for a recent comprehensive review on clinical applications of microbubbles, see 2) and molecular targeting in preclinical studies 2-7 and clinical trials 8. MCA's, although typically used to enhance US contrast for imaging, are becoming increasingly popular for systemically targeting drugs and genes to malignant tissue 9, 10.…”
Section: Introductionmentioning
confidence: 99%
“…This introductory chapter is devoted broadly to the topic of theranostics and the role of functional nanometer-sized agents in personalized medicine [1,50,59,[67][68][69][70][71][72][73][74]. Over the past 2 decades, the field has gained a tremendous boost with high impending for translation.…”
Section: Resultsmentioning
confidence: 99%
“…A variety of molecules is used as ligants, including cytokines and inflammatory mediators. Although current experience derives from experimental studies only, molecular imaging has allowed the demonstration of inflammation in patients with CAD, or in rejected heart transplantations [57]. Additionally atherosclerosis, thrombi and neovascularization can be targeted.…”
Section: Future Directionsmentioning
confidence: 99%