Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters

Jokerst, Jesse V.; Pohling, Christoph; Gambhir, Sanjiv S.

doi:10.1557/mrs.2013.157

Cited by 12 publications

(13 citation statements)

References 67 publications

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“…When a laser beam interacts with a molecule, photons are scattered and the inelastic scattering can be measured using complex and expensive systems consisting of fiber bundles, lenses, spectrometers, and photomultiplier tubes (PMT). However, as label-free Raman imaging is time consuming, the low signal intensity can be overcome by the use of surface-enhanced Raman nanoparticles (SERS) to amplify the signal [35][36]. One limitation in fluorescence imaging is an often reduced signal in vivo compared to ex vivo imaging of the same specimen.…”

Section: Raman Spectroscopymentioning

confidence: 99%

Emerging Intraoperative Imaging Modalities to Improve Surgical Precision

et al. 2018

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Intraoperative imaging (IOI) is performed to guide delineation and localization of regions of surgical interest. While oncological surgical planning predominantly utilizes x-ray computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound (US), intraoperative guidance mainly remains on surgeon interpretation and pathology for confirmation. Over the past decades however, intraoperative guidance has evolved significantly with the emergence of several novel imaging technologies, including fluorescence-, Raman, photoacoustic-, and radio-guided approaches. These modalities have demonstrated the potential to further optimize precision in surgical resection and improve clinical outcomes for patients. Not only can these technologies enhance our understanding of the disease, they can also yield large imaging datasets intraoperatively that can be analyzed by deep learning approaches for more rapid and accurate pathological diagnosis. Unfortunately, many of these novel technologies are still under preclinical or early clinical evaluation. Organizations like the Intra-Operative Imaging Study Group of the European Society for Molecular Imaging (ESMI) support interdisciplinary interactions with the aim to improve technical capabilities in the field, an approach that can succeed only if scientists, engineers, and physicians work closely together with industry and regulatory bodies to resolve roadblocks to clinical translation. In this review, we provide an overview of a variety of novel IOI technologies, discuss their challenges, and present future perspectives on the enormous potential of IOI for oncological surgical navigation.

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Section: Raman Spectroscopymentioning

confidence: 99%

Emerging Intraoperative Imaging Modalities to Improve Surgical Precision

et al. 2018

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“…This is based on the Raman effect, which is the inelastic molecular scattering of incident light (Jokerst et al, 2013 ). Raman imaging (RI) has high specificity because each chemical bond has a characteristic vibrational energy.…”

Section: Bioimaging Techniquesmentioning

confidence: 99%

Upconversion Nanoparticles for Bioimaging and Regenerative Medicine

González‐Béjar

Francés‐Soriano

Pérez‐Prieto

2016

Front. Bioeng. Biotechnol.

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Nanomaterials are proving useful for regenerative medicine in combination with stem cell therapy. Nanoparticles (NPs) can be administrated and targeted to desired tissues or organs and subsequently be used in non-invasive real-time visualization and tracking of cells by means of different imaging techniques, can act as therapeutic agent nanocarriers, and can also serve as scaffolds to guide the growth of new tissue. NPs can be of different chemical nature, such as gold, iron oxide, cadmium selenide, and carbon, and have the potential to be used in regenerative medicine. However, there are still many issues to be solved, such as toxicity, stability, and resident time. Upconversion NPs have relevant properties such as (i) low toxicity, (ii) capability to absorb light in an optical region where absorption in tissues is minimal and penetration is optimal (note they can also be designed to emit in the near-infrared region), and (iii) they can be used in multiplexing and multimodal imaging. An overview on the potentiality of upconversion materials in regenerative medicine is given.

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“…Gold nanoparticles, without a passivating shell, also have the tendency to aggregate in vivo, which can lead to signal inhomogeneity; in turn, this can result in attenuated signal or, occasionally, increased signal due to the formation of hot-spots between the aggregated nanoparticles, potentially compromising the accuracy and interpretation of experimental data (4, 5). The placement of a silica or polyethylene glycol (PEG) coating on the surface of gold nanoparticles can prevent aggregation and also confers increased stability within a variety of microenvironments (6–9).…”

Section: Sers Probe Design Considerations For In Vivo Cancer Imagingmentioning

confidence: 99%

“…In general, there are two major categories of strategies to achieve selective accumulation of nanoparticles in tumors, which also apply to SERS nanoparticles: passive and active targeting (4). Since the above-mentioned SERRS-nanostars (10) do not require specific targeting moieties on the nanoparticle surface and yet allow robust tumor imaging, we conclude that their uptake depends on a property of cancer that is not unique to a specific type, subtype, or stage.…”

Section: Nanoparticle Targeting – Passive Versus Activementioning

confidence: 99%

Surface-Enhanced Raman Spectroscopy: A New Modality for Cancer Imaging

2015

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While surface-enhanced Raman scattering (SERS) spectroscopy has traditionally been employed as an in vitro analytical tool, in the past few years the first reports of the feasibility of in vivo imaging of cancer with biocompatible SERS probes have emerged. SERS imaging has great potential in the field of medical imaging because it offers several major theoretical advantages over other molecular imaging methods. Medical imaging using SERS nanoprobes can yield higher sensitivity and higher signal specificity than other imaging modalities while also offering multiplexing capabilities that allow for unique applications. This review article explains the principles of SERS and highlights recent advances for in vivo cancer imaging. In order to present the abilities of the method as accurate as possible, the discussion is limited to studies in which the imaging data were confirmed by histological correlation.

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Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters

Cited by 12 publications

References 67 publications

Emerging Intraoperative Imaging Modalities to Improve Surgical Precision

Emerging Intraoperative Imaging Modalities to Improve Surgical Precision

Upconversion Nanoparticles for Bioimaging and Regenerative Medicine

Surface-Enhanced Raman Spectroscopy: A New Modality for Cancer Imaging

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