Molecular Imprinted Hydrogels in Drug Delivery Applications

Bates, Jeffrey; Whitson, Luke R.; Albertson, Kelan; Hickerson, Nathan S.; Nichols, Patrick E.; Larson, Bethany E.; Sparks, Taylor D.

doi:10.1557/opl.2015.455

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The concentration profile and mass transfer for this application will be investigated by determining the diffusion of small molecules through the polymer matrix. The polymer network designed in this study is responsive to changes in pH, which becomes one of the driving interactions responsible for the extraction of the drug from the matrix [18]. The research goal of this project is to determine how the mass transfer varies as a function of time and amount of cycling, investigate the time-release kinetics of the drug delivery material, and explore the reversibility of binding interactions between the drug and the polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Molecular Imprinted Hydrogels as Drug Delivery Vehicles

Nichols¹,

Mortensen²,

Tingy³

et al. 2018

Biochem Pharmacol

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Molecular imprinted hydrogels can be made to have a high affinity for a certain compound or drug. A hydrogel can be loaded with a drug and upon a swelling action induced by a pH change or hydration process, the matrix can swell and release the drug. Our hydrogels mimic contact lenses for the purposes of ocular drug delivery. Our hydrogels were imprinted and tested with a prostaglandin derivative, bimatoprost used in the treatment for glaucoma. Major problems preventing entrance to clinical use are bioavailability and drug release kinetics. Our lenses were made to overcome these issues, and were tested for efficacy. The gels were synthesized and were tested to establish a clinically relevant drug delivery profile. Using UV-Vis Spectrophotometry we analyzed the drug released from the gels before, and after cycling. They show a desired and consistent dose release, and a kinetic profile that would indicate a large bioavailability. The testing would also indicate a strong reusability potential, as the hydrogels can release the same amount of drug for over 10,000 cycles (to simulate a daily use). Our samples were tested to show a 10 hour dose release time and they were able to withstand over 10,000 cycles of a swelling mechanical force without degradation or drug release alteration. We imaged the hydrogel lenses with an SEM to visualize if the matrix encountered deterioration over time due to the drug release mechanism. This is due to a need to understand long term use stability. The test results indicate a strong potential to be able to enter the market and be approved for clinical use.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Molecular Imprinted Hydrogels as Drug Delivery Vehicles

Nichols¹,

Mortensen²,

Tingy³

et al. 2018

Biochem Pharmacol

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Multicomponent Hydrogels for Bioimaging and Biosensing Applications

Bates,

Toews,

Pachauri

et al. 2023

Multicomponent Hydrogels

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Multicomponent hydrogels are practical materials for bioimaging and biosensing applications because of their biocompatibility, selectivity, and ability to interact with biological molecules. For biosensing, hydrogel-based sensors include both a signal recognition and a transduction component. For biosensing, the applications are broad and include the use of signal transducers that can be used in simple systems that may have applications in wearable electronics through mechanisms that require the use of complicated instrumentation. For bioimaging, multicomponent hydrogels have some of the same imaging properties as systems found in the body, but can easily bond with proteins and other biological molecules and can target specific tissues or other systems that are imaged. In bioimaging, multicomponent hydrogels are coupled with imaging equipment, including ultrasound, computed tomography, fluorescence, and others. In this chapter, we discuss methods used for both bioimaging and biosensing, the stimuli response of hydrogel materials, the types of signals obtained, signal transduction methods, and applications in both biosensing and bioimaging.

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Exploration of Polytetrafluoroethylene as a Potential Material Replacement for Hemodialysis Applications

2016

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Dialysis is the process by which an artificial kidney device removes waste and excess water from a patient. An outstanding problem with dialysis is that the body has a remarkable immune function where proteins and antigens mark foreign objects as possible threats despite the biocompatibility of the material. Upon adhesion to polymeric materials used currently in dialysis, proteins are lost. In this study, polytetrafluoroethylene (PTFE) is investigated as a potential replacement material for dialysis tubing because of its unreactive nature. The focus is to determine if PTFE will prove a viable material in minimizing protein adhesion and further reducing antibody loss of the patient. Protein loss as a function of filtration time was measured. PVC and PTFE materials were investigated following the same battery of testing where the protein concentrations in the blood were characterized using UV Visible spectrophotometry. Results demonstrate a loss of nearly 12 percent of blood proteins to the PVC material over the course of a typical dialysis treatment. Conversely, the protein loss due to adhesion to PTFE was less than two percent.

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Molecular Imprinted Hydrogels in Drug Delivery Applications

Cited by 3 publications

References 17 publications

Pharmacokinetics of Molecular Imprinted Hydrogels as Drug Delivery Vehicles

Pharmacokinetics of Molecular Imprinted Hydrogels as Drug Delivery Vehicles

Multicomponent Hydrogels for Bioimaging and Biosensing Applications

Exploration of Polytetrafluoroethylene as a Potential Material Replacement for Hemodialysis Applications

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