Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control

Dai, Chenglong; Liu, Changsheng; Wei, Jie; Hong, Hao; Zhao, Qing

doi:10.1016/j.biomaterials.2010.06.049

Cited by 118 publications

(84 citation statements)

References 40 publications

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“…The mesoporous silica xerogels (MSX) with large surface area and high porosity developed by Li et al [99] had great capacity for water absorption with little heat effect when in contact with blood and could be used to staunch bleeding. On this basis, Dai et al [44] fabricated a series of chitosan-silica xerogel beads (CSSX) with good biocompatibility by combining a liquid-absorbing mesoporous silica xerogel core and a macroporous chitosan coating layer via the modified sol-gel process and polyethylene glycol (PEG) molecular imprinting technique (Figure 8). In vivo and in vitro blood clotting evaluation showed that the CSSX beads could significantly accelerate the contact activation pathway of the coagulation cascade and achieve desirable hemostatic effects.…”

Section: Cs-based Composite Hemostatic Materialsmentioning

confidence: 99%

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

et al. 2018

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Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxicity, has been widely applied in bio-medicine, the chemical industry, the food industry and cosmetics. The excellent hemostatic properties of CS have been extensively studied. As a result, chitosan-based composite hemostatic materials have been emerging. In this review, the hemostatic mechanism of chitosan is briefly discussed, and then the progress of research on chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers are introduced. Finally, future perspectives of chitosan-based composite hemostatic materials are given. The objective of this review is to provide a reference for further research and development of effective hemostatic materials.

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Section: Cs-based Composite Hemostatic Materialsmentioning

confidence: 99%

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

et al. 2018

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“…[1][2][3] Hence, in designing a new inorganic/organic biocomposite, the choice of an inorganic component and a polymer are key to formulating a composite with favorable bioperformance. Nano hydroxyapatite biomaterials have being extensively developed for biomedical applications in recent decades because they have good biocompatibility and bioactivity, and can bond with host bone directly.…”

Section: Introductionmentioning

confidence: 99%

Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer

Hong

Gong²,

Yang³

et al. 2012

IJN

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Background and methods:A nano calcium-deficient hydroxyapatite (n-CDHA)-multi(amino acid) copolymer (MAC) composite bone substitute biomaterial was prepared using an in situ polymerization method. The composition, structure, and compressive strength of the composite was characterized, and the in vitro degradability in phosphate-buffered solution and preliminary cell responses to the composite were investigated. Results: The composite comprised n-CDHA and an amide linkage copolymer. The compressive strength of the composite was in the range of 88-129 MPa, varying with the amount of n-CDHA in the MAC (ranging from 10 wt% to 50 wt%). Weight loss from the composite increased (from 32.2 wt% to 44.3 wt%) with increasing n-CDHA content (from 10 wt% to 40 wt%) in the MAC after the composite was soaked in phosphate-buffered solution for 12 weeks. The pH of the soaking medium varied from 6.9 to 7.5. MG-63 cells with an osteogenic phenotype were well adhered and spread on the composite surface. Viability and differentiation increased with time, indicating that the composite had no negative effects on MG-63 cells. Conclusion:The n-CDHA-MAC composite had good cytocompatibility and has potential to be used as a bone substitute.

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“…[3][4][5] As an effective molecule-delivering vector, the mesoporous materials with the pore size of a few nanometers have a high capacity to encapsulate large amounts of molecules. 4,6 Moreover, the pore size, pore volume, and microstructure of the mesoporous materials can be adjusted according to the size and performances of delivered molecules. 6,7 Recently, the application of mesoporous materials for bone regeneration has been proposed, and the tunable pore size and high pore volume of the mesoporous materials might allow them to load osteogenic agents and promote new bone tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…4,6 Moreover, the pore size, pore volume, and microstructure of the mesoporous materials can be adjusted according to the size and performances of delivered molecules. 6,7 Recently, the application of mesoporous materials for bone regeneration has been proposed, and the tunable pore size and high pore volume of the mesoporous materials might allow them to load osteogenic agents and promote new bone tissue regeneration. 6,8 The biomacromolecule bone morphogenetic protein (BMP) with strong boneinducing activity has been considered to play important roles in bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 Recently, the application of mesoporous materials for bone regeneration has been proposed, and the tunable pore size and high pore volume of the mesoporous materials might allow them to load osteogenic agents and promote new bone tissue regeneration. 6,8 The biomacromolecule bone morphogenetic protein (BMP) with strong boneinducing activity has been considered to play important roles in bone regeneration. [9][10][11] Furthermore, recombinant human bone morphogenetic protein-2 (rhBMP-2) has Dovepress Dovepress 1716 song et al received US Food and Drug Administration approval for application in the enhancement of lumbar spine fusion and treatment of acute tibial fractures.…”

Section: Introductionmentioning

confidence: 99%

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Mesoporous calcium–silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2

Song

Qian

et al. 2015

IJN

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Mesoporous calcium–silicon xerogels with a pore size of 15 nm (MCS-15) and pore volume of 1.43 cm 3 /g were synthesized by using 1,3,5-mesitylene (TMB) as the pore-expanding agent. The MCS-15 exhibited good degradability with the weight loss of 50 wt% after soaking in Tris-HCl solution for 56 days, which was higher than the 30 wt% loss shown by mesoporous calcium–silicon xerogels with a pore size of 4 nm (MCS-4). The pore size and pore volume of MCS-15 had significant influences on load and release of recombinant human bone morphogenetic protein-2 (rhBMP-2). The MCS-15 had a higher capacity to encapsulate a large amount of rhBMP-2; it could adsorb 45 mg/g of rhBMP-2 in phosphate-buffered saline after 24 hours, which was more than twice that with MCS-4 (20 mg/g). Moreover, the MCS-15 system exhibited sustained release of rhBMP-2 as compared with MCS-4 system (showing a burst release). The MCS-15/rhBMP-2 system could promote the proliferation and differentiation of human mesenchymal stem cells, showing good cytocompatibility and bioactivity. The results indicated that MCS-15, with larger mesopore size and higher pore volume, might be a promising carrier for loading and sustained release of rhBMP-2, which could be used as bone repair material with built-in osteoinduction function in bone reconstruction.

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Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control

Cited by 118 publications

References 40 publications

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer

Mesoporous calcium–silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2

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Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control

Cited by 118 publications

References 40 publications

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

Degradable biocomposite of nano calcium- deficient hydroxyapatite-multi(amino acid) copolymer

Mesoporous calcium&ndash;silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of&nbsp;rhBMP-2

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Mesoporous calcium–silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2