Molecular imprinting: A new tool for drug innovation

Nostrum, Cornelus F. van

doi:10.1016/j.ddtec.2005.05.004

Cited by 54 publications

(21 citation statements)

References 25 publications

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“…The use of polymers with smart recognition properties are also interesting in that the activities of the drugs are significantly influenced by molecular recognition phenomena. The biological environment is generally characterized by a high number of binding events with large association constants (in the order of magnitude of 10 3 -10 12 l/mol [103]). Optimized MI systems can reach similar values and then can be considered interesting candidates for such applications.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

Gagliardi

Mazzolai

2015

Future Med. Chem.

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Molecular imprinting (MI) represents a strategy to introduce a 'molecular memory' in a polymeric system obtaining materials with specific recognition properties. MI particles can be used as drug delivery systems providing a targeted release and thus reducing the side effects. The introduction of molecular recognition properties on a polymeric drug carrier represents a challenge in the development of targeted delivery systems to increase their efficiency. This review will summarize the limited number of drug delivery MI particles described in the literature along with an overview of potential solutions for a larger exploitation of MI particles as targeted drug delivery carriers. Molecularly imprinted drug carriers can be considered interesting candidates to significantly improve the efficiency of a controlled drug treatment.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

Gagliardi

Mazzolai

2015

Future Med. Chem.

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“…The application of molecularly imprinted polymers (MIPs) in drug discovery is a new approach in screening libraries of pure compounds or extracts of natural products [26,27]. MIPs are highly cross-linked polymers with molecular recognition properties, i.e.…”

Section: Introductionmentioning

confidence: 99%

Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer

et al. 2010

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Hypoxia-Inducible Factor 1 (HIF-1), a transcriptional activator, is highly involved in the pathology of cancer. Inhibition of HIF-1 retards tumor growth and enhances treatment efficiency when used in combination with chemo- or radiation therapy. The recent validation of HIF-1 as an important drug target in cancer treatment has stimulated efforts to identify and isolate natural or synthetic HIF-1 inhibitors. In the present study, quercetin, a known inhibitor of HIF-1, was imprinted in a polymer matrix in order to prepare a Molecularly Imprinted Polymer (MIP), which was subsequently used for the selective isolation of new inhibitors from frankincense, a gum resin used as anticancer remedy in traditional medicine. The frankincense components isolated by Solid Phase Extraction on MIP (MIP-SPE), efficiently inhibited the transcriptional activity of HIF-1 and decreased the protein levels of HIF-1α, the regulated subunit of HIF-1. The selective retention of acetyl 11-ketoboswellic acid (AKBA, one of the main bioactive components of frankincense) by MIP led to the revealing of its inhibitory activity on the HIF-1 signaling pathway. AKBA was selectively retained by SPE on the quercetin imprinted polymer, with an imprinting effect of 8.1 ± 4.6. Overall, this study demonstrates the potential of MIP application in the screening, recognition and isolation of new bioactive compounds that aim selected molecular targets, a potential that has been poorly appreciated until.

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“…It involves preparation of a solid material, usually a synthetic polymer containing cavities with shape and functional groups complementary to the imprinted template molecule [21]. The inherent selectivity associated with molecularly imprinted polymers (MIPs) has made them efficient materials for use in the SPME technique.…”

Section: Introductionmentioning

confidence: 99%

Nonderivatized Sarcosine Analysis by Gas Chromatography after Solid-Phase Microextraction by Newly Synthesized Monolithic Molecularly Imprinted Polymer

Hashemi‐Moghaddam

Hagigatgoo

2015

Chromatographia

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Molecular imprinting: A new tool for drug innovation

Cited by 54 publications

References 25 publications

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

Molecularly Imprinted Polymeric Micro- and Nano-Particles for the Targeted Delivery of Active Molecules

Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer

Nonderivatized Sarcosine Analysis by Gas Chromatography after Solid-Phase Microextraction by Newly Synthesized Monolithic Molecularly Imprinted Polymer

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