Molecular imprinting: A useful approach for drug delivery

Zaidi, Shabi Abbas

doi:10.1016/j.mset.2019.10.012

Cited by 67 publications

(46 citation statements)

References 54 publications

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“…Under this process, with an increasing concentration of analytes, further rebinding may induce a stronger redox reaction and increase peak current value. Additionally, the shape of the imprinted cavities complements that of the prototype following the lock-key principle [ 55 ]; thus, when a target with the same configuration as that of the template comes into the vicinity of the MIP, it immediately responds to the analyte. This mechanism can be the reason for higher selectivity in MIP sensors.…”

Section: Resultsmentioning

confidence: 99%

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

Aaryashree

Takeda

Kanai

et al. 2020

Sensors

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An inexpensive disposable electrochemical drug sensor for the detection of drugs (vancomycin, meropenem, theophylline, and phenobarbital) is described. Molecularly imprinted polymer (MIP) templated with the target drugs was immobilized on the surface of graphite particles using a simple radical polymerization method and packed into the working electrode of a three-electrode ceramic-based chip sensor. Differential pulse voltammetry (DPV) was used to determine the relationship between the response current and the concentration of the targeted drug while using one sensor chip for one single operation. The time required for each DPV measurement was less than 2 min. Concentrations corresponding to the therapeutic range of these drugs in plasma were taken into account while performing DPV. In all the cases, the single-used MIP sensor showed higher sensitivity and linearity than non-imprinted polymer. The selectivity test in drugs with a structure similar to that of the target drugs was performed, and it was found that MIP-based sensors were more selective than the untreated ones. Additionally, the test in whole blood showed that the presence of interfering species had an insignificant effect on the diagnostic responses of the sensor. These results demonstrate that the disposable MIP-sensor is promising for quick and straightforward therapeutic drug monitoring to prevent the toxic side effects and the insufficient therapeutic effect due to the overdose and underdose, respectively.

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Section: Resultsmentioning

confidence: 99%

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

Aaryashree

Takeda

Kanai

et al. 2020

Sensors

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“…DDS are able to deliver a specific drug to its target (i.e., local delivery), without damaging non-target sites [ 103 ]. Moreover, they can be employed to release drugs over an extended period of time without delivering too low or too high a dose (controlled release), in order to achieve the maximum therapeutic effect [ 104 ]. As an example of the application of MIPs to DDS, Mao et al have developed MIP nanospheres by precipitation polymerization, which are able to bind the antibacterial vancomycin and release it over an extended period of time (over 18 days) and with higher release rates at lower pH values.…”

Section: Molecular Imprinting For Te Applicationsmentioning

confidence: 99%

Molecular Imprinting Strategies for Tissue Engineering Applications: A Review

2021

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Tissue Engineering (TE) represents a promising solution to fabricate engineered constructs able to restore tissue damage after implantation. In the classic TE approach, biomaterials are used alongside growth factors to create a scaffolding structure that supports cells during the construct maturation. A current challenge in TE is the creation of engineered constructs able to mimic the complex microenvironment found in the natural tissue, so as to promote and guide cell migration, proliferation, and differentiation. In this context, the introduction inside the scaffold of molecularly imprinted polymers (MIPs)—synthetic receptors able to reversibly bind to biomolecules—holds great promise to enhance the scaffold-cell interaction. In this review, we analyze the main strategies that have been used for MIP design and fabrication with a particular focus on biomedical research. Furthermore, to highlight the potential of MIPs for scaffold-based TE, we present recent examples on how MIPs have been used in TE to introduce biophysical cues as well as for drug delivery and sequestering.

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“…Typically in MIP systems, polymeric constructs are designed with the target protein acting as a template; removal of the template then creates a free site for further association of the protein [ 157 ]. MIPs have been shown to significantly increase drug loading in comparison to non-imprinted systems, as well as slowing release [ 158 ]; they have also been described as having stability and durability against harsh conditions [ 159 ]. However, some challenges do exist for MIPs, such as an initial burst release with hydrogel MIP systems (due to swelling behaviour) and a lack of sufficient in vivo studies [ 159 ].…”

Section: General Strategies To Increase Duration Of Actionmentioning

confidence: 99%

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

et al. 2020

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Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.

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Molecular imprinting: A useful approach for drug delivery

Cited by 67 publications

References 54 publications

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode

Molecular Imprinting Strategies for Tissue Engineering Applications: A Review

Injectables and Depots to Prolong Drug Action of Proteins and Peptides

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