Molecular imprinting-based ratiometric fluorescence sensors for environmental and food analysis

Wen, Yuhao; Sun, Dani; Zhang, Yue; Zhang, Zhong; Chen, Lingxin; Li, Jinhua

doi:10.1039/d3an00483j

Cited by 24 publications

(11 citation statements)

References 118 publications

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“…111 Recent advances toward molecular imprinting-based radiometric fluorescence (MI-RFL) sensors have been achieved, which offer high selectivity and sensitivity for analyzing environmental pollutants and harmful substances in food, emphasizing new construction strategies, improved sensing techniques, and their applications while addressing future challenges and prospects for enhancing sensitivity and applicability. 2 For enhancing MI-RFL nanosensor performance, certain issues like fluorescence intensity, nanostructure, and color range while proposing strategies like dual-emission modes and multitarget detection should be addressed. 8 Recent studies depicted that MIP-based sensors on combining the advantages of MIP receptors and different sensing platforms can possess extensive applications in food detection.…”

Section: Sample Pretreatmentmentioning

confidence: 99%

“…MIPs because of their easier synthesis, physicochemical stability, and simple nature can replace antibodies thereby serving as sensitive recognition units . Recent advances toward molecular imprinting-based radiometric fluorescence (MI-RFL) sensors have been achieved, which offer high selectivity and sensitivity for analyzing environmental pollutants and harmful substances in food, emphasizing new construction strategies, improved sensing techniques, and their applications while addressing future challenges and prospects for enhancing sensitivity and applicability . For enhancing MI-RFL nanosensor performance, certain issues like fluorescence intensity, nanostructure, and color range while proposing strategies like dual-emission modes and multitarget detection should be addressed .…”

Section: Application Of Mipsmentioning

confidence: 99%

“…In addition to soil pollution, which is brought on by the use of pesticides, sludge, nonbiodegradable materials, and the disposal of hazardous waste, water pollution can also be caused by chemicals, nutrients, leachates, and oil spills . Pollutants of the modern world include synthetic compounds found in many products, including cosmetics, personal care items, pesticides, and pharmaceuticals. − The generation of anthropogenic chemicals increased considerably worldwide between 1930 and 2000. Between 2002 and 2011, almost half of all chemicals produced had deleterious effects on the environment, with over 70% of these compounds having a negative impact on the ecosystem. , Aside from that, biological micropollutants such as bacteria and viruses have been implemented into water supplies by human activity.…”

Section: Introductionmentioning

confidence: 99%

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Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

Sengar,

Kumari,

Sengar

et al. 2024

ACS Appl. Polym. Mater.

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Molecularly imprinted polymer (MIP) technology and its prospective used in the surveillance of the environment are the focus of this review article, which aims to give an in-depth understanding of the field. The approach of generating highly cross-linked polymeric structures with effective binding sites that precisely match the analyte of interest by templating with it is covered in the study as a means of producing biomimetic ligands. It also highlights the stability and robustness of MIPs, making them ideal for challenging environmental conditions. The originality of this paper lies in its exploration of various physical forms and synthesis techniques of MIPs, as well as the development of specialized MIPs to address specific challenges. It emphasizes the diverse applications of MIPs in environmental monitoring, including sample pretreatment, solid-phase extraction, microextraction, sensors, and chromatographic separations with the discussion on integration of MIPs with advanced analytical tools, highlighting the potential for enhancing the accuracy and reliability of environmental monitoring. Furthermore, the integration of MIPs with advanced analytical instruments opens up new possibilities for qualitative and quantitative evaluation of detection systems. Capillary electrochromatography and thin-layer chromatography are mentioned as the examples of analytical techniques that can be seamlessly integrated with MIPs. This integration enables improved accuracy and reliability in environmental monitoring, enhancing our understanding and protection of the environment. It not only explores the fundamentals of MIP technology but also delves into the synthesis methods, specialized MIPs, and integration with advanced analytical instruments. By providing this holistic view, the paper offers a valuable resource for researchers and practitioners interested in utilizing MIPs for environmental monitoring applications.

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Section: Sample Pretreatmentmentioning

confidence: 99%

Section: Application Of Mipsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

Sengar,

Kumari,

Sengar

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

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“…19,20 recognition elements, MIPs have the advantages of high stability, ease of synthesis, etc. 21 However, the presence of macromolecules in real samples may occupy the surface space of MIPs and thus interfere with the selective recognition of template molecules by the imprinted sites. Moreover, the nonspecific binding during the synthesis of MIPs also influences the detection sensitivity of complex substrates, affecting the recognition effect and accuracy.…”

Section: Introductionmentioning

confidence: 99%

“…Food samples are normally very complex and require high selectivity and stability of the sensor for trace analysis in the actual sample, which makes it especially necessary to develop specific recognition molecules. Molecularly imprinted polymers (MIPs) are synthesized with a high degree of spatial, structural, and point-of-action uniformity with the target molecule. , As an excellent alternative to traditional recognition elements, MIPs have the advantages of high stability, ease of synthesis, etc . However, the presence of macromolecules in real samples may occupy the surface space of MIPs and thus interfere with the selective recognition of template molecules by the imprinted sites.…”

Section: Introductionmentioning

confidence: 99%

Construction of Aptamer-Molecularly-Imprinted Fluorescent Covalent Organic Framework and Its Collaborative Recognition of Diethylstilbestrol

Zhao,

Lin,

et al. 2023

ACS Food Sci. Technol.

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As a synthetic estrogen substance, diethylstilbestrol (DES) is often used in the aquaculture industry and easily enters the human body and causes health threats. Herein, a biosensing method based on fluorescent covalent organic frameworks (COFs) with aptamers and molecularly imprinted polymers (MIPs) was constructed. TP-COF with stable fluorescence emission was used as a fluorescence signal, coupled with DES aptamer, and further coated with MIPs. The obtained aptamer-molecularly imprinted COFs (COFs-Apt@MIPs) could recognize DES through the cooperation of aptamers and MIPs and induce fluorescence quenching. Dual recognition elements not only significantly improved affinity and specificity but also reduced the interference from complex matrix environments. The sensor exhibited a low detection limit (0.23 mg/L) and a good linear range (0.4−25.6 mg/L) for DES. It was further applied to detect fish samples with a recovery of 98.68%−101.97%, indicating its prospect of application in the detection of various fish drug residues.

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Advances in Bioreceptor Layer Engineering in Nanomaterial‐based Sensing of Pseudomonas Aeruginosa and its Metabolites

Lapitan,

Felisilda,

Tiangco

et al. 2024

Chemistry An Asian Journal

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Pseudomonas aeruginosa is an opportunistic pathogen that infects wounds and burns and causes severe infections in humans. The high virulence, the emergence of antibiotic‐resistant strains, and the easy transmissibility of P. aeruginosa necessitate its fast detection and control. The gold standard for detecting P. aeruginosa, the plate culture method, though reliable, takes several days to complete. Therefore, developing accurate, rapid, and easy‐to‐use diagnostic tools for P. aeruginosa is highly desirable. Nanomaterial‐based biosensors are at the forefront of detecting P. aeruginosa and its secondary metabolites. This review summarises the biorecognition elements, biomarkers, immobilisation strategies, and current state‐of‐the‐art biosensors for P. aeruginosa. The review highlights the underlying principles of bioreceptor layer engineering and the design of nanomaterial‐based optical, electrochemical, mass‐based, and thermal biosensors. The advantages and disadvantages of these biosensors and their future point‐of‐care applications are also discussed.

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Molecular imprinting-based ratiometric fluorescence sensors for environmental and food analysis

Abstract: Environmental protection and food safety are closely related to the healthy development of human society; there is an urgent need for relevant analytical methods to determine environmental pollutants and harmful...

Cited by 24 publications

References 118 publications

Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

Construction of Aptamer-Molecularly-Imprinted Fluorescent Covalent Organic Framework and Its Collaborative Recognition of Diethylstilbestrol

Advances in Bioreceptor Layer Engineering in Nanomaterial‐based Sensing of Pseudomonas Aeruginosa and its Metabolites

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