Molecular imprinting of a small substituted phenol of biological importance

Petcu, Miruna; Cooney, Janine M.; Cook, Christian J.; Lauren, D. R.; Schaare, Peter; Holland, Patricia

doi:10.1016/s0003-2670(00)01354-4

Cited by 19 publications

(10 citation statements)

References 12 publications

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“…An attempt to combine this method with a fluorescent monomer has also been described. 499 Other hydroxyl group containing molecules have been imprinted using this method: nandrolone, 500 propofol, 501 other phenols and bis-phenol A. 484,485,502 This approach was also used in the preparation of mentholimprinted polymers by ring-opening metathesis polymerization (ROMP).…”

Section: 480mentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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Over 1450 references to original papers, reviews and monographs have herein been collected to document the development of molecular imprinting science and technology from the serendipitous discovery of Polyakov in 1931 to recent attempts to implement and understand the principles underlying the technique and its use in a range of application areas. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by papers dealing with fundamental aspects of molecular imprinting and the development of novel polymer formats. Thereafter, literature describing attempts to apply these polymeric materials to a range of application areas is presented.

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Section: 480mentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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“…Both 4-vinylphenol and propofol-4-vinylphenyl carbonate were synthesized and characterized as described elsewhere (Petcu et al, 2001). The imprinted polymer (P1) mixture consisted of propofol-4-vinylphenyl carbonate (100 mg, 0.31 mmol), EDMA (1.1 ml, 5.8 mmol), ABCHC (20 mg, 0.082 mmol) and porogen (hexane/toluene 9:1 v/v, 2.5 ml).…”

Section: Polymer Synthesismentioning

confidence: 99%

“…A template/functional monomer/EDMA ratio of 1:4:25 was used (Petcu et al, 2001). To the template-monomer mixture in the appropriate solvent (2 ml/g of monomers) was added 0.003 equivalents of ABCHC (corresponding to 1 mol% of polymerizable double bonds).…”

Section: Polymer Synthesismentioning

confidence: 99%

“…Molecular imprinting strategies were proposed as a possible alternative approach for producing propofol recognizing materials (Petcu et al, 2001). Preliminary studies using the non-covalently interacting functional monomer methacrylic acid (MAA) indicated the need for more defined template-functional monomer interactions, as the performance of this polymer system was not sufficient for it to be used in antibody-like applications.…”

Section: Introductionmentioning

confidence: 99%

“…The monomer has a scissile carbonate moiety (the sacrificial spacer) which upon hydrolysis liberates propofol and renders a polymer with residual phenolic groups appropriately placed for hydrogen bonding with propofol (Scheme 1). This resulted in polymers demonstrating increased levels of specific binding (Petcu et al, 2001;Petcu et al, 2004). The better performance of these materials was attributed to the control over the orientation and proximity of the propofol moiety's phenolic oxygen with respect to the polymer backbone during the polymerization process provided by the covalent linkage between template and subsequent polymer bound hydroxyl functionality.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Probing the limits of molecular imprinting: strategies with a template of limited size and functionality

Petcu

Karlsson²,

Whitcombe

et al. 2008

J of Molecular Recognition

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A series of polymers molecularly imprinted with the general anaesthetic propofol were synthesized using both semi- and non-covalent approaches. The polymers were evaluated with respect to template rebinding in both aqueous and organic media. In aqueous media, the observed propofol binding in these polymer systems was largely hydrophobic and non-specific in nature. In non-polar solvents such as hexane, electrostatic (hydrogen bonding) interactions dominate resulting in some selectivity. The implication of these results, in conjunction with those obtained using structures of similar size in other studies, is that propofol, a template possessing limited functionality and size, appears to define the lower limit for template size and degree of functionalization that can be used for the creation of ligand-selective recognition sites in molecularly imprinted polymers. Furthermore, studies with alternative ligands indicate that the steric crowding of a ligand's functionality to the polymer contributes to the extent of polymer-ligand recognition.

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Molecularly Imprinted Polymers as Biomimetic Molecules: Synthesis and their Pharmaceutical Applications

Rezapour¹,

Faridbod

Norouzi

2015

Handbook of Polymers for Pharmaceutical Technologies

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Molecular imprinting of a small substituted phenol of biological importance

Cited by 19 publications

References 12 publications

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Probing the limits of molecular imprinting: strategies with a template of limited size and functionality

Molecularly Imprinted Polymers as Biomimetic Molecules: Synthesis and their Pharmaceutical Applications

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