Molecular imprinting ratiometric fluorescence sensor for highly selective and sensitive detection of phycocyanin

Wang, Xiaoyan; Yu, Jialuo; Kang, Qi; Shen, Dazhong; Li, Jinhua; Chen, Lingxin

doi:10.1016/j.bios.2015.10.019

Cited by 85 publications

(44 citation statements)

References 26 publications

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“…More excitingly, ratiometric fluorescence detection can achieve higher sensitivity of the molecularly imprinted sensors. 596 Chen et al 597 developed a SiO 2 @NBD@MIPs ratiometric fluorescent sensor for the sensitive detection of PC using nitrobenzoxadiazole (NBD) as a fluorescent signal source based on FRET between APTES-NBD conjugates at 535 nm and PC at 657 nm. As seen from Fig.…”

Section: View Article Onlinementioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Section: View Article Onlinementioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…Then, the red QD-embedded silica nanoparticles (QD@SiO 2 ) were synthesized by reverse microemulsion according to the report method (Wang et al, 2009). Meanwhile, the APTES-NBD conjugates were synthesized using our developed method (Wang et al, 2016). Afterwards, the ratiometric fluorescence MIPs sensor, marked as QD@SiO 2 @NBD@MIPs, was prepared by a facile sol-gel process.…”

Section: Preparation Of Mip-based Fluorescence Sensormentioning

confidence: 99%

“…However, either turn off or turn on fluorescence intensity as a sole responsive signal, the signal is easily interfered by various experimental factors, such as the change in fluorescence intensity and instrumental conditions. Excitingly, ratiometric measurements have the advantages to eliminate these environmental effects and give more precise measurement owing to their self-referencing capability by calculation of two emission intensity ratio instead of the absolute intensity of one peak (Liu et al, 2013;Wang et al, 2016;Zhang et al, 2014). In general, two individual materials with different fluorescence emission wavelengths can be used to build ratiometric sensors (Xu and Lu, 2015).…”

Section: Introductionmentioning

confidence: 99%

A molecular imprinting-based turn-on Ratiometric fluorescence sensor for highly selective and sensitive detection of 2,4-dichlorophenoxyacetic acid (2,4-D)

Wang

et al. 2016

Biosensors and Bioelectronics

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a b s t r a c tA novel molecular imprinting-based turn-on ratiometric fluorescence sensor was constructed via a facile sol-gel polymerization for detection of 2,4-dichlorophenoxyacetic acid (2,4-D) on the basis of photoinduced electron transfer (PET) by using nitrobenzoxadiazole (NBD) as detection signal source and quantum dots (QDs) as reference signal source. With the presence and increase of 2,4-D, the amine groups on the surface of QDs@SiO 2 could bind with 2,4-D and thereby the NBD fluorescence intensities could be significantly enhanced since the PET process was inhibited, while the QDs maintained constant intensities. Accordingly, the ratio of the dual-emission intensities of green NBD and red QDs could be utilized for turn-on fluorescent detection of 2,4-D, along with continuous color changes from orange-red to green readily observed by the naked eye. The as-prepared fluorescence sensor obtained high sensitivity with a low detection limit of 0.14 μM within 5 min, and distinguished recognition selectivity for 2,4-D over its analogs. Moreover, the sensor was successfully applied to determine 2,4-D in real water samples, and high recoveries at three spiking levels of 2,4-D ranged from 95.0% to 110.1% with precisions below 4.5%. The simple, rapid and reliable visual sensing strategy would not only provide potential applications for high selective ultratrace analysis of complicated matrices, but also greatly enrich the research connotations of molecularly imprinted sensors.

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“…The coupled transitions result in quenching of the fluorescence of donor (AC molecules) and enhancement in fluorescence intensity of the acceptor (L-cys-CdSe/ZnS QDs). 45 The distance between donor and acceptor is also a critical parameter of FRET processes since FRET depends on the donor quantum yield and will occur over a limited distance (Förster distance (Å)) when the overlap between the emission spectrum of the donor and the absorption spectrum of the acceptor is greater than 30 % and the distance is less than 10 nm. 46 The Förster distance in the L-cys-CdSe/ZnS QDs-AC system was found to be 6.1 nm which meets this distance requirement for FRET to occur.…”

Section: Proposed Mechanismmentioning

confidence: 99%

Development of a Thiol-capped Core/Shell Quantum Dot Sensor for Acetaminophen

Montaseri

Adegoke

2019

S.Afr.j.chem.

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Acetaminophen (AC) is a frequently used pharmaceutical which has been detected in water systems and is of concern due to its potential environmental impacts. In this study, three quantum dot (QD)-ligand systems, namely L-cysteine (L-cys)-, N-acetyl-L-cysteine (NAC)-and glutathione (GSH)-capped CdSe/ZnS quantum dots, were synthesized and tested for the fluorescence detection of acetaminophen. Among the synthesized aqueous core/shell quantum dots, L-cys-CdSe/ZnS QDs were found to be optimal with high sensitivity for the fluorescence detection of acetaminophen. The L-cys-CdSe/ZnS QDs were of a zinc blende crystal structure and displayed excellent fluorescence intensity and photostability and provided a photoluminescence quantum yield of 77 %. The fluorescence of L-cys-CdSe/ZnS QDs was enhanced by the introduction of AC enabling the development of a fast and simple method for the detection of AC. Under optimal conditions, F-F 0 was linearly proportional to the concentration of AC from 3.0-100 nmol L-1 with limits of detection and quantification of 1.6 and 5.3 nmol L-1 , respectively. Some related pharmaceutical compounds including epinephrine hydrochloride (EP), L-ascorbic acid (AA), uric acid (UA), dopamine hydrochloride (DA) and 4-aminophenol (4-AP) did not interfere with the sensing of AC. The probe was also successfully applied in the determination of AC in tap and river water matrices.

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Molecular imprinting ratiometric fluorescence sensor for highly selective and sensitive detection of phycocyanin

Cited by 85 publications

References 26 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

A molecular imprinting-based turn-on Ratiometric fluorescence sensor for highly selective and sensitive detection of 2,4-dichlorophenoxyacetic acid (2,4-D)

Development of a Thiol-capped Core/Shell Quantum Dot Sensor for Acetaminophen

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