Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression

Tiwari, Vishvanath

doi:10.1016/j.phymed.2018.09.214

Cited by 8 publications

(5 citation statements)

References 78 publications

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“…However, the specific mechanism of action of many phytochemicals and flavonoids is sometimes still unclear. In this framework, in the last few years, several research studies have been conducted in different countries to prove such antimicrobial efficiency [ 39 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.

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Section: Introductionmentioning

confidence: 99%

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

et al. 2021

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“…Such promiscuity or multitarget affinity potentially hinders the generation of possible resistance mechanisms in the bacteria [ 18 ]. As it is schematized in Figure 1 , the different bacterial molecules targeted by phytochemicals include cell wall [ 19 ] and the cell membrane components [ 20 ] as well as proteins with diverse locations and functions [ 21 ], and thus with the ability of even interfering in the nutrient metabolism and motility [ 22 ]. In addition to these pharmacological direct activities, it has been shown that there are phytochemicals, such as certain polyphenols, that are capable of sensitizing ARB by reversing their resistance mechanisms and making them more susceptible to traditional drugs [ 23 , 24 ].…”

Section: Antimicrobial Capacity Of Phytochemicalsmentioning

confidence: 99%

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

et al. 2023

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Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined with antibacterial phytochemicals could help achieve greater antibacterial capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims to provide an updated overview of the current state of research on the use of phytochemical-based nanomaterials for the treatment against ARB, with a special focus on polymeric nanofibers and nanoparticles. The review discusses the various types of phytochemicals that have been incorporated into different nanomaterials, the methods used to synthesize these materials, and the results of studies evaluating their antimicrobial activity. The challenges and limitations of using phytochemical-based nanomaterials, as well as future directions for research in this field, are also considered here. Overall, this review highlights the potential of phytochemical-based nanomaterials as a promising strategy for the treatment against ARB, but also stresses the need for further studies to fully understand their mechanisms of action and optimize their use in clinical settings.

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“…These alternative natural antibiotics can act through: (a) a bacteriostatic mechanism, the germs being prevented from multiplying; (b) or bactericidal, the germs being completely destroyed (Tiwari, 2019). Oleanolic acid F. benghalensis Bhar and Thakur (1981) β-Amyrone F. pandurata Ramadan et al (2009) Ursane triterpenes α-Amyrin F. religiosa F. Lacor F. pandurata Ramadan et al (2009), Singh (2006), Swami and Bisht (1996) α-Amyrin acetate F. hirta F. racemosa F. Pseudopalma F. pandurata F. Chlamydocarpa Ragasa and Tsai (2009), Ramadan et al (2009) concentration (MIC) ranging from 250 to 500 μg/ml (Rahman et al, 2014).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Section: Pharmacological Evidence Of Ficus Plants: From Traditional Umentioning

confidence: 99%

Ficusplants: State of the art from a phytochemical, pharmacological, and toxicological perspective

Salehi

Mishra

Nigam

et al. 2020

Phytotherapy Research

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, after first online publication: The author Javad Sharifi-Rad added has added a second affiliation "Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador" in this version] secondary metabolites that have shown diverse applications. This comprehensive review describes for Ficus genus the phytochemical compounds, traditional uses and contemporary pharmacological activities such as antioxidant, cytotoxic, antimicrobial, anti-inflammatory, antidiabetic, antiulcer, and anticonvulsant. An extended survey of the current literature (Science Direct, Scopus, PubMed) has been carried out as part of the current work. The trends in the phytochemistry, pharmacological mechanisms and activities of Ficus genus are overviewed in this manuscript: antimicrobial, antidiabetic, anti-inflammatory and analgesic activity, antiseizure and anti-Parkinson's diseases, cytotoxic and antioxidant. Healthpromoting effects, recent human clinical studies, safety and adverse effects of Ficus plants also are covered. The medical potential and long-term pharmacotherapeutic use of the genus Ficus along with no serious reported adverse events, suggests that it can be considered as being safe.

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Molecular insight into the therapeutic potential of phytoconstituents targeting protein conformation and their expression

Cited by 8 publications

References 78 publications

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids

Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review

Ficusplants: State of the art from a phytochemical, pharmacological, and toxicological perspective

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