2022
DOI: 10.2217/nnm-2022-0117
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Molecular Insights and Therapeutic Implications of Nanoengineered Dietary Polyphenols for Targeting Lung Cancer: Part II

Abstract: Flavonoids represent a major group of polyphenolic compounds. Their capacity to inhibit tumor proliferation, cell cycle, angiogenesis, migration and invasion is substantially responsible for their chemotherapeutic activity against lung cancer. However, their clinical application is limited due to poor aqueous solubility, low permeability and quick blood clearance, which leads to their low bioavailability. Nanoengineered systems such as liposomes, nanoparticles, micelles, dendrimers and nanotubes can considerab… Show more

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Cited by 3 publications
(7 citation statements)
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“…Additionally, the bulk of plant-mediated polyphenols are primarily found in the form of glycosides with several sugar units and acylated sugars that are arranged at different positions throughout the polyphenol skeleton. 25,26 Chemically, the polyphenols are defined as phytocompounds having phenolic structure-based properties and exhibit diverse multiple subtypes, including flavonoids, phenolic acids, lignans (LIG), and stilbenes (STB), that are also further individually classified in various subgroups. 25,26,60 In accordance to epidemiologic evidence, a food intake having a high content of fruits and vegetables could minimize the probability of occurrence of specific cancers.…”
Section: Classification Of Various Polyphenols and Their Role In Canc...mentioning
confidence: 99%
See 4 more Smart Citations
“…Additionally, the bulk of plant-mediated polyphenols are primarily found in the form of glycosides with several sugar units and acylated sugars that are arranged at different positions throughout the polyphenol skeleton. 25,26 Chemically, the polyphenols are defined as phytocompounds having phenolic structure-based properties and exhibit diverse multiple subtypes, including flavonoids, phenolic acids, lignans (LIG), and stilbenes (STB), that are also further individually classified in various subgroups. 25,26,60 In accordance to epidemiologic evidence, a food intake having a high content of fruits and vegetables could minimize the probability of occurrence of specific cancers.…”
Section: Classification Of Various Polyphenols and Their Role In Canc...mentioning
confidence: 99%
“…25,26 Chemically, the polyphenols are defined as phytocompounds having phenolic structure-based properties and exhibit diverse multiple subtypes, including flavonoids, phenolic acids, lignans (LIG), and stilbenes (STB), that are also further individually classified in various subgroups. 25,26,60 In accordance to epidemiologic evidence, a food intake having a high content of fruits and vegetables could minimize the probability of occurrence of specific cancers. 61 Natural polyphenols have implicated potential anticancer or antitumor activity due to various biological mechanisms associated with different signaling pathways such as cell propagation, differentiation, relocation, angiogenesis, metastasis, and cellular death (Figure 3).…”
Section: Classification Of Various Polyphenols and Their Role In Canc...mentioning
confidence: 99%
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