Molecular Insights into a Novel Cu(I)-Sensitive ArsR/SmtB Family Repressor in Extremophile Acidithiobacillus caldus

Qiu, Yongkang; Tong, Yanjun; Yang, Hailin; Feng, Shoushuai

doi:10.1128/aem.01266-22

Appl Environ Microbiol

2023

DOI: 10.1128/aem.01266-22

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Molecular Insights into a Novel Cu(I)-Sensitive ArsR/SmtB Family Repressor in Extremophile Acidithiobacillus caldus

Yongkang Qiu

Yanjun Tong

Hailin Yang

et al.

Abstract: Copper (Cu) resistance among various microorganisms is attracting interest. The chemolithoautotrophic bacterium A. caldus , which can tolerate extreme copper stress (≥10 g/L Cu ions), is typically used to bioleach chalcopyrite (CuFeS 2 ).

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Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus

Zhi,

Liu,

Geng

et al. 2024

Emerging Microbes & Infections

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Brucellosis, caused by the intracellular pathogen Brucella , is a major zoonotic infection that promotes reproductive disease in domestic animals and chronic debilitating conditions in humans. The ArsR family of transcriptional regulators plays key roles in diverse cellular processes, including metal ion homeostasis, responding to adverse conditions, and virulence. However, little is known about the function of ArsR family members in Brucella . Here, we identified ArsR2 as a nonclassical member of the family that lacks autoregulatory function, but which nevertheless plays a vital role in maintaining copper homeostasis in B. abortus . ArsR2 is a global regulator of 241 genes, including those involved in the VirB type IV secretion system (T4SS). Significantly, ArsR2 regulates T4SS production in B. abortus by targeting VjbR which encodes a LuxR-type family transcriptional regulator. Moreover, copper modulates transcriptional activity of ArsR2, but not of VjbR. Furthermore, deletion of arsR2 attenuated virulence in a mouse model. Collectively, these findings enhance understanding of the mechanism by which ArsR proteins regulate virulence gene expression in pathogenic Brucella species.

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Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus

Zhi,

Liu,

Geng

et al. 2024

Emerging Microbes & Infections

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show abstract

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Molecular Insights into a Novel Cu(I)-Sensitive ArsR/SmtB Family Repressor in Extremophile Acidithiobacillus caldus

Abstract: Copper (Cu) resistance among various microorganisms is attracting interest. The chemolithoautotrophic bacterium A. caldus , which can tolerate extreme copper stress (≥10 g/L Cu ions), is typically used to bioleach chalcopyrite (CuFeS 2 ).

Cited by 1 publication

References 49 publications

Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus

Copper sensing transcription factor ArsR2 regulates VjbR to sustain virulence in Brucella abortus

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