Molecular insights into the Ebola virus life cycle

Bodmer, Bianca S.; Hoenen, Thomas; Wendt, Lisa

doi:10.1038/s41564-024-01703-z

Nat Microbiol

2024

DOI: 10.1038/s41564-024-01703-z

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Molecular insights into the Ebola virus life cycle

Bianca S. Bodmer,

Thomas Hoenen,

Lisa Wendt

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2024

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Cited by 2 publications

References 116 publications

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Hippo signaling pathway regulates Ebola virus transcription and egress

Liang,

Djurkovic,

Leavitt

et al. 2024

Nat Commun

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Filovirus-host interactions play important roles in all stages of the virus lifecycle. Here, we identify LATS1/2 kinases and YAP, key components of the Hippo pathway, as critical regulators of EBOV transcription and egress. Specifically, we find that when YAP is phosphorylated by LATS1/2, it localizes to the cytoplasm (Hippo “ON”) where it sequesters VP40 to prevent egress. In contrast, when the Hippo pathway is “OFF”, unphosphorylated YAP translocates to the nucleus where it transcriptionally activates host genes and promotes viral egress. Our data reveal that LATS2 indirectly modulates filoviral VP40-mediated egress through phosphorylation of AMOTp130, a positive regulator of viral egress, but more surprisingly that LATS1/2 kinases directly modulate EBOV transcription by phosphorylating VP30, an essential regulator of viral transcription. In sum, our findings highlight the potential to exploit the Hippo pathway/filovirus axis for the development of host-oriented countermeasures targeting EBOV and related filoviruses.

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Hippo signaling pathway regulates Ebola virus transcription and egress

Liang,

Djurkovic,

Leavitt

et al. 2024

Nat Commun

View full text Add to dashboard Cite

show abstract

Novel filoviruses: indication of a global threat or cause to reassess our risk perception?

Groseth,

Hoenen

2024

npj Viruses

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Molecular insights into the Ebola virus life cycle

Cited by 2 publications

References 116 publications

Hippo signaling pathway regulates Ebola virus transcription and egress

Hippo signaling pathway regulates Ebola virus transcription and egress

Novel filoviruses: indication of a global threat or cause to reassess our risk perception?

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