Molecular Interactions of Carcinogenic Aromatic Amines, 4-Aminobiphenyl and 4,4’-Diaminobiphenyl, with Lactoperoxidase – Insight to Breast Cancer

Sheikh, Ishfaq Ahmad; Beg, M.A.; Yasir, Muhammad

doi:10.21873/anticanres.12075

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…The mainstream view is that smoking-specific DNA adducts ( 116 , 117 ) (chemical carcinogens are activated by enzymes into electrophile and covalent combined with DNA, which are used to show DNA damage of specific carcinogens in human tissues ( 118 )), mutations, and mal-regulated signaling pathways ( 119 ) represented by p53 [genes that inhibit cells from turning into cancer cells ( 75 )] are the most important factors in BC ( 120 ). Animal and in vitro studies have shown that fat-soluble mutagenic compounds ( 121 ) in tobacco smoke, such as polycyclic hydrocarbons ( 122 ), aromatic amines ( 20 ) and N-nitrosamines ( 123 ), are major components of DNA adducts that can induce breast tumors ( 117 ) and have been detected in human milk ( 116 ). Compared with nonsmokers, detectable increases in cancer-causing DNA adducts were found in BC tissues and normal tissue adjacent to tumors in smokers ( 34 , 124 ).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The potential role of smoking in BC risk has been under intense discussion ( 17 , 18 ). Although BC is not initially thought to be a tobacco-related cancer, over the past few decades, many chemicals contained in tobacco have been investigated to be a trigger of BC, such as 4-aminobiphenyl ( 19 , 20 ) and benzopyrene ( 21 , 22 ). In addition, evidence of the role of active smoking ( 23 , 24 ) and secondhand smoke ( 25 , 26 ) in the etiology of BC is accumulating, based on adequate animal trials ( 27 , 28 ) and relevant epidemiological evidence ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

et al. 2022

Front. Oncol.

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BackgroundThe effect of tobacco on breast cancer (BC) is controversial. The purpose of this study was to investigate the relationship between tobacco and BC.MethodsA search was conducted in PubMed, EBSCO, Web of Science and Cochrane Library databases before February 2022. The adjusted odd ratio (OR) and corresponding 95% confidence interval (CI) were used to examine the relationship between active or passive smoking and BC risk.ResultsA total of 77 articles composed of 2,326,987 participants were included for this meta-analysis. Active (OR=1.15, 95% CI=1.11-1.20, p<0.001) and passive (OR=1.17, 95% CI=1.09-1.24, p<0.001) smoking increased the risk of BC in the female population, especially premenopausal BC (active smoking: OR=1.24, p<0.001; passive smoking: OR=1.29, p<0.001), but had no effect on postmenopausal BC (active smoking: OR=1.03, p=0.314; passive smoking: OR=1.13, p=0.218). Active smoking increased the risk of estrogen receptor-positive (ER+) BC risk (OR=1.13, p<0.001), but had no effect on estrogen receptor-negative (ER-) BC (OR=1.08, p=0.155). The risk of BC was positively associated with the duration and intensity of smoking, negatively associated with the duration of smoking cessation. Active smoking increased the risk of BC in the multiparous population (OR=1.13, p<0.001), but had no effect on the nulliparous population (OR=1.05, p=0.432), and smoking before the first birth (OR=1.22, 95% CI=1.17-1.27) had a greater impact on the risk of BC than smoking after the first birth (OR=1.08, 95% CI=1.04-1.12).ConclusionSmoking (active and passive) increased the risk of BC in women. The effect of smoking on BC was influenced by smoking-related factors (duration, intensity, years of quitting), population-related factors (fertility status), and BC subtypes.Systematic Review Registrationidentifier CRD42022322699.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

et al. 2022

Front. Oncol.

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“…Lactoperoxidase is an enzyme that is produced in mammary gland cells and is involved in the one-electron oxidation of 17β-estradiol to a reactive phenoxyl radical [270]. Lactoperoxidase plays a role in breast carcinogenesis through the activation of carcinogenic aromatic amines such as benzidine, 2aminofluorene and others, resulting in the formation of metabolites that are highly reactive and covalently bind to DNA [271].…”

Section: Estrogens and Oxidative Stress In Breast Cancermentioning

confidence: 99%

Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production

Bel’skaya,

Dyachenko

2024

CIMB

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This review systematizes information about the metabolic features of breast cancer directly related to oxidative stress. It has been shown those redox changes occur at all levels and affect many regulatory systems in the human body. The features of the biochemical processes occurring in breast cancer are described, ranging from nonspecific, at first glance, and strictly biochemical to hormone-induced reactions, genetic and epigenetic regulation, which allows for a broader and deeper understanding of the principles of oncogenesis, as well as maintaining the viability of cancer cells in the mammary gland. Specific pathways of the activation of oxidative stress have been studied as a response to the overproduction of stress hormones and estrogens, and specific ways to reduce its negative impact have been described. The diversity of participants that trigger redox reactions from different sides is considered more fully: glycolytic activity in breast cancer, and the nature of consumption of amino acids and metals. The role of metals in oxidative stress is discussed in detail. They can act as both co-factors and direct participants in oxidative stress, since they are either a trigger mechanism for lipid peroxidation or capable of activating signaling pathways that affect tumorigenesis. Special attention has been paid to the genetic and epigenetic regulation of breast tumors. A complex cascade of mechanisms of epigenetic regulation is explained, which made it possible to reconsider the existing opinion about the triggers and pathways for launching the oncological process, the survival of cancer cells and their ability to localize.

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“…On the other hand, the ability of LPO to activate certain carcinogens was also identified. There are studies proving that LPO increases the ability to bind DNA while entering the peroxidase cycle with arylamine carcinogens, which is the cause of the mutagenic activity of these compounds [157,158].…”

Section: Biological Role Of the Lpo Systemmentioning

confidence: 99%

The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products

Magacz

Kędziora

Sapa

et al. 2019

IJMS

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Lactoperoxidase (LPO) present in saliva are an important element of the nonspecific immune response involved in maintaining oral health. The main role of this enzyme is to oxidize salivary thiocyanate ions (SCN−) in the presence of hydrogen peroxide (H2O2) to products that exhibit antimicrobial activity. LPO derived from bovine milk has found an application in food, cosmetics, and medical industries due to its structural and functional similarity to the human enzyme. Oral hygiene products enriched with the LPO system constitute an alternative to the classic fluoride caries prophylaxis. This review describes the physiological role of human salivary lactoperoxidase and compares the results of clinical trials and in vitro studies of LPO alone and complex dentifrices enriched with bovine LPO. The role of reactivators and inhibitors of LPO is discussed together with the possibility of using nanoparticles to increase the stabilization and activity of this enzyme.

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Molecular Interactions of Carcinogenic Aromatic Amines, 4-Aminobiphenyl and 4,4’-Diaminobiphenyl, with Lactoperoxidase – Insight to Breast Cancer

Cited by 3 publications

References 17 publications

The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production

The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products

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