Molecular Interactions of Diphenhydramine-hydrochloride with Some Imidazolium-Based Ionic Liquids in Aqueous Media at T = 293.15–313.15 K: Volumetric, Acoustic, and UV Absorption Studies

Abstract

From the density (ρ) and speed-of-sound (u) measurements, the interactions of the drug diphenhydramine-hydrochloride (DPH) with three imidazolium-based ionic liquids (ILs) (1-butyl-3-methylimidazolium chloride, [C4mim]­[Cl], 1-hexyl-3-methylimidazolium chloride1, [C6mim]­[Cl], and 1-methyl-3-octylimidazolium chloride, [C8mim]­[Cl]) have been investigated in aqueous medium at T = 293.15–313.15 K and experimental pressure p = 0.1 MPa. From the density calculations, the apparent molar volume (V ϕ) and the apparent partial molar volumes of transfer (Δ t V ϕ o) have been determined for various solutions of DPH in aqueous solutions of different ILs. In addition, from the speed-of-sound data, the apparent molar isentropic compressibility (K ϕ), apparent partial molar isentropic compressibility (K ϕ o), and apparent partial molar isentropic compressibility of transfer (Δ tKϕ ο ) have been calculated. The pair and triplet interaction coefficients are derived from apparent partial molar volumes of transfer. For the present mixtures, the absorption spectra have been also recorded using a UV–visible spectrophotometer. Using Hepler’s constant, the structure-making nature of the solute has been confirmed. All these calculated parameters provide detailed insights into various physicochemical interactions prevailing in the ternary system and confirm the presence of a strong attractive interaction between DPH and ILs.

Thermophysical Studies on Molecular Interactions of Semicarbazide Hydrochloride/Domiphen Bromide in Aqueous Deep Eutectic Solvent Media at Various Temperatures

“…The limiting apparent molar volumes have been inferred for domiphen bromide and semicarbazide hydrochloride in water and in aqueous maline via the use of relation (3) presented below. , Here, S v stands for the Debye–Huckel limiting slope that varies with temperature and charge on the species. It furnishes information regarding the various assorted interactions persisting among solute molecules.…”

Interaction Studies of Chlorpheniramine Maleate in Mono and Dihydric Alcohols by Density, Viscosity, and HPLC Methods

“…The combination of change in volume of solute after interaction with the solvent and innate volume of solute is defined as the standard partial molar volume of transfer [23]. Below-mentioned contributions are helpful in defining innate volume [24][25]…”

“…where V vw is the volume occupied by the solute because of its van der Waals volume [24] and V void is the volume related to the voids and empty spaces which are present thereto, including the involvement of a solute molecule to its standard partial molar volume.…”

Effect of Tri-Sodium Citrate and Tri-Potassium Citrate on Solute–Solvent Interactions of Diphenhydramine-Hydrochloride Drug in Aqueous Solutions from the Viewpoint of Vapor Liquid Equilibria and Volumetric and Transport Properties

“…Volumetric and transport properties of solutions containing DPH-HCl, fructose, galactose, lactose, and water have been studied in our previous work for detecting the effect of fruit and milk sugars on solute–solvent interactions of systems considered . Volumetric and transport properties of DPH-HCl in water content solutions of NaCl, KCl, RbCl, MgCl 2 , CaCl 2 , and SrCl 2 have been studied by Sharma et al at 298.15–313.15 K. Measurements of volumetric, acoustic, and UV absorption properties have been used to determine the molecular interactions in solutions containing DPH-HCl, 1-hexyl-3-methylimidazolium chloride1, 1-methyl-3-octylimidazolium chloride, 1-butyl-3-methylimidazolium chloride, and water at T = 293.15–313.15 K by Singh et al Behboudi et al studied the interactions of DPH-HCl with choline bi-tartrate and choline lactate by measuring the thermodynamic, volumetric, and transport properties in aqueous solutions at T = 288.15 to 318.15 K. Volumetric, ultrasonic, and viscometric properties were also utilized by Bandral et al to study the systems containing DPH-HCl, l-serine, l-histidine, and water at 293.15–318.15 K. Water activity has been measured and correlated in aqueous solutions containing diphenhydramine hydrochloride in our previous works. , VLE, volumetric, and transport properties of tri-sodium citrate, Na 3 Cit, and tri-potassium citrate, K 3 Cit, in aqueous solutions have been measured in several studies. − All the results obtained in these works have been interpreted according to solute–solvent interactions in terms of hydrophilic hydration around the polar head groups of drugs, hydrophobic hydration around the aromatic rings on drugs, and hydrophilic–ionic interactions between the – + NH 3 R/–OCHPh 2 /Cl – ,/group of DPH-HCl and ions of electrolytes.…”