Molecular investigation of Coleopteran specific α-Amylase inhibitors from Amaranthaceae members

Rane, Ashwini S.; Venkatesh, Varun; Joshi, Rakesh S.; Giri, Ashok P.

doi:10.1016/j.ijbiomac.2020.07.219

Cited by 8 publications

(1 citation statement)

References 23 publications

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“…It is classified as a knottin-like protein according to its structure [70]. Rane et al have identified three previously unidentified knottin-like α-AIs: Amaranthus hypochondriacus (AhAI2), Alternanthera sessilis (AsAI), and Chenopodium quinoa (CqAI), which have been proven to have the specific inhibitory activity of Coleopteran α-amylases and no cross-reactivity with mammalian α-amylases [71].…”

Section: Insect α-Amylase Inhibitorsmentioning

confidence: 99%

Insect α-Amylases and Their Application in Pest Management

Wang,

Huang,

Cao

et al. 2023

Molecules

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Amylase is an indispensable hydrolase in insect growth and development. Its varied enzymatic parameters cause insects to have strong stress resistance. Amylase gene replication is a very common phenomenon in insects, and different copies of amylase genes enable changes in its location and function. In addition, the classification, structure, and interaction between insect amylase inhibitors and amylases have also invoked the attention of researchers. Some plant-derived amylase inhibitors have inhibitory activities against insect amylases and even mammalian amylases. In recent years, an increasing number of studies have clarified the effects of pesticides on the amylase activity of target and non-target pests, which provides a theoretical basis for exploring safe and efficient pesticides, while the exact lethal mechanisms and safety in field applications remain unclear. Here, we summarize the most recent advances in insect amylase studies, including its sequence and characteristics and the regulation of amylase inhibitors (α-AIs). Importantly, the application of amylases as the nanocide trigger, RNAi, or other kinds of pesticide targets will be discussed. A comprehensive foundation will be provided for applying insect amylases to the development of new-generation insect management tools and improving the specificity, stability, and safety of pesticides.

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Section: Insect α-Amylase Inhibitorsmentioning

confidence: 99%