2023
DOI: 10.1101/2023.05.26.23290534
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Molecular Investigation of DENV serotypes in the dengue outbreak of 2022 in Nepal

Nishan Katuwal,
Aastha Shrestha,
Urusha Ranjitkar
et al.

Abstract: Introduction Dengue, a viral infection highly prevalent in tropical regions, exhibits local variations in risk that are influenced by a combination of climatic, socioeconomic, and environmental factors. The disease is caused by four distinct yet closely related serotypes of the dengue virus: DENV-1, DENV-2, DENV-3, and DENV-4. Objectives The objective of this study is to identify the different serotypes of dengue virus responsible for the 2022 outbreak in Nepal, where dengue has been prevalent since 2006 but w… Show more

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Cited by 2 publications
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“…However, such introduction of a new serotype may favor a larger dengue outbreak in future [ 48 ]. The serotype displacement phenomenon perhaps had a crucial impact on the historically biggest dengue epidemic which occurred in 2022 in Nepal, though the serotype data for each year is not available [ 15 , 23 , 49 ]. Clade or genotype shifts may also contribute to the rapid surge in dengue cases, as seen in the neighboring country Bangladesh during the 2017 outbreak [ 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, such introduction of a new serotype may favor a larger dengue outbreak in future [ 48 ]. The serotype displacement phenomenon perhaps had a crucial impact on the historically biggest dengue epidemic which occurred in 2022 in Nepal, though the serotype data for each year is not available [ 15 , 23 , 49 ]. Clade or genotype shifts may also contribute to the rapid surge in dengue cases, as seen in the neighboring country Bangladesh during the 2017 outbreak [ 50 ].…”
Section: Discussionmentioning
confidence: 99%