Molecular karyotype variation in<i>Leishmania (Viannia) peruviana</i>: indication of geographical populations in Peru distributed along a north-south cline

Dujardin, JC; Llanos-Cuentas, Alejandro; Cáceres, Abraham G.; Arana, Margarita; Dujardin, Jean‐Pierre; Guerrini, F.; Gómez, Julio; Arroyo, Juan; Doncker, Simonne De; Jacquet, D.; Hamers, R.; Guerra, Humberto; Ray, D. Le; Arévalo, Jorge

doi:10.1080/00034983.1993.11812777

Cited by 47 publications

(43 citation statements)

References 23 publications

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“…In evolutionary terms, one might expect divergence of populations living in ecologic isolation, and such processes have been demonstrated for other groups of organisms in the region. 39,40 Thus, these Bartonella isolates are likely to be members of a population not limited by geographic location, altitude, etc., and they may be endemic throughout Peru and beyond. Such an observation is in concordance with the isolation of the same Bartonella species from the blood of small mammals populations in different geographic regions of the United Kingdom (Ball ML, 1994.…”

Section: Discussionmentioning

confidence: 99%

Survey of Bartonella species infecting intradomicillary animals in the Huayllacallán Valley, Ancash, Peru, a region endemic for human bartonellosis.

Birtles¹,

Canales²,

Ventosilla³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. The natural cycle of Bartonella bacilliformis remains uncertain, and the suspected existence of animal reservoirs for the bacterium has never been convincingly demonstrated. We conducted a survey of Bartonella species infecting intradomicillary animals in a bartonellosis-endemic region of Peru, obtaining blood from 50 animals living in the homes of 11 families whose children had recently had bartonellosis. Bartonella-like bacteria were recovered from four of nine small rodents included in the study, but from none of the 41 domesticated animals. Identification and comparison of these isolates, and two Bartonella-like isolates obtained from Phyllotis mice in a different endemic region of Peru using serologic and genotypic methods indicated that although none were strains of B. bacilliformis, five were probably representatives of three previously unrecognized Bartonella species and one was a likely strain of the pathogenic species B. elizabethae.

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Section: Discussionmentioning

confidence: 99%

Survey of Bartonella species infecting intradomicillary animals in the Huayllacallán Valley, Ancash, Peru, a region endemic for human bartonellosis.

Birtles¹,

Canales²,

Ventosilla³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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“…In particular, we are concerned with the proportion of infections which induce a clinical response, the degree of acquired immunity following either clinical or sub-clinical infections, and the frequency of reactivations. The analysis derives from the results of a cross-sectional and prospective longitudinal field study on Andean cutaneous leishmaniasis (uta) in six Peruvian valleys, where the only parasite species isolated from patients with cutaneous lesions is L. peruviana [28,29]. MATERIALS [30].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous leishmaniasis in the Peruvian Andes: an epidemiological study of infection and immunity

et al. 1995

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SUMMARYA prospective longitudinal survey of cutaneous leishmaniasis (Leishmania peruviana) was carried out in Peru on a study population of 4716 persons living in 38 villages (Departments of Lima, Ancash and Piura). Demographic and clinical data were collected from all individuals, and a Montenegro skin test (MST) was carried out on 72 % (3418) of the study population. Each household was revisited at 3-monthly intervals for up to 2 years to detect new leishmaniasis cases; 497 people received a second MST at the end of the study. Analysis of the epidemiological data indicated that (i) 17 % (16/94) of all infections were subclinical, (ii) this percentage increased significantly with age, (iii) clinical infections led to 73-9 % protective immunity (95 % C.I. 53-0-85-5 %) and relatively permanent MST responsiveness (recovery rate = 0-0098/year; 95% C.I. 0000-00020/year), (iv) sub-clinical infections led to protective immunity, which was positively correlated with their MST induration size (increasing by 17-9% per mm; P < 0-0001), and a mean MST recovery rate of 0-414/year (4/421 manmonths), and (v) recurrent leishmaniasis was dominated by reactivations, not by reinfections.

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“…Our analysis of the MLEE data showed a large number of recurrent mutations in the Viannia parasites, which makes it reasonable to attribute some variation to recombination. Moreover, many authors have reported evidence of hybrid formation in Leishmania (Evans et al 1987, Kelly et al 1991, Darce et al 1991, BonfanteGarrido et al 1992, Dujardin et al 1993, Belli et al 1994, Noyes et al 1996, Bañuls et al 1997, Delgado et al 1997, reinforcing the idea that sexual reproduction may occur in Leishmania, but at a level as yet undefined. It is important to emphasize that rare or occasional bouts of sexual recombination in a normally asexual organism can have a profound effect on the extent of genetic diversity (Cibulskis 1988).…”

mentioning

confidence: 98%

Genetic Diversity in Natural Populations of New World Leishmania

Cupolillo

Momen

Grimaldi³

1998

Mem. Inst. Oswaldo Cruz

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Molecular karyotype variation inLeishmania (Viannia) peruviana: indication of geographical populations in Peru distributed along a north-south cline

Cited by 47 publications

References 23 publications

Survey of Bartonella species infecting intradomicillary animals in the Huayllacallán Valley, Ancash, Peru, a region endemic for human bartonellosis.

Survey of Bartonella species infecting intradomicillary animals in the Huayllacallán Valley, Ancash, Peru, a region endemic for human bartonellosis.

Cutaneous leishmaniasis in the Peruvian Andes: an epidemiological study of infection and immunity

Genetic Diversity in Natural Populations of New World Leishmania

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