Molecular kinesis in cellular function and plasticity

Tiedge, Henri; Bloom, Floyd E.; Richter, Dietmar

doi:10.1073/pnas.131145198

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…Cell nuclear ER in interneurons plays a role in regulating the inhibitory tone on pyramidal cells that helps to regulate synapse formation and, furthermore, may reduce neuronal excitability in relation to seizures and seizure‐related damage. Concurrently, ER in dendrites and dendritic spines may be associated with the activation of mRNA translation from polyribosomes 102 or the endomembrane structures found in spines 103 . In addition, other second messenger signaling effects might include the phosphorylation of neurotransmitter receptors or ion channels.…”

Section: The Hippocampus As a Target Of Sex Hormones Particularly Esmentioning

confidence: 99%

Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling

McEwen

2010

Annals of the New York Academy of Sciences

303

223

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The adult brain is much more resilient and adaptable than previously believed, and adaptive structural plasticity involves growth and shrinkage of dendritic trees, turnover of synapses and limited amounts of neurogenesis in the forebrain, especially the dentate gyrus of the hippocampal formation. Stress and sex hormones help to mediate adaptive structural plasticity, which has been extensively investigated in hippocampus and to a lesser extent in prefrontal cortex and amygdala, all brain regions that are involved in cognitive and emotional functions. Stress and sex hormones exert their effects on brain structural remodeling through both classical genomic as well as nongenomic mechanisms, and they do so in collaboration with neurotransmitters and other intra-and extracellular mediators. This review will illustrate the actions of estrogen on synapse formation in the hippocampus and the process of stress-induced remodelling of dendrites and synapses in the hippocampus, amygdala and prefrontal cortex. The influence of early developmental epigenetic events, such as early life stress and brain sexual differentiation, is noted along with the interactions between sex hormones and the effects of stress on the brain. Because hormones influence brain structure and function and because hormone secretion is governed by the brain, applied molecular neuroscience techniques can begin to reveal the role of hormones in brain-related disorders and the treatment of these diseases. A better understanding of hormone-brain interactions should promote more flexible approaches to the treatment of psychiatric disorders, as well as their prevention through both behavioral and pharmaceutical interventions.

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Section: The Hippocampus As a Target Of Sex Hormones Particularly Esmentioning

confidence: 99%

Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling

McEwen

2010

Annals of the New York Academy of Sciences

303

223

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“…Estrogen enhances neurite outgrowth by repressing GFAP and reorganizing laminin (Rozovsky et al, 2002). Estrogen can activate neurite mRNA translation (Pierce et al, 2000; Tiedge et al, 2001; Steward and Schuman, 2001).…”

Section: 1 Gender and Estrogenmentioning

confidence: 99%

Neuroplasticity in Alzheimer's disease

Teter

Ashford

2002

J of Neuroscience Research

107

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Ramon y Cajal proclaimed in 1928 that “once development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably. In the adult centers the nerve paths are something fixed, ended and immutable. Everything must die, nothing may be regenerated. It is for the science of the future to change, if possible, this harsh decree.” (Ramon y Cajal, 1928). In large part, despite the extensive knowledge gained since then, the latter directive has not yet been achieved by ‘modern’ science. Although we know now that Ramon y Cajal's observation on CNS plasticity is largely true (for lower brain and primary cortical structures), there are mechanisms for recovery from CNS injury. These mechanisms, however, may contribute to the vulnerability to neurodegenerative disease. They may also be exploited therapeutically to help alleviate the suffering from neurodegenerative conditions. Published 2002 Wiley‐Liss, Inc.

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“…Kinesins and dyneins play a significant role in neural transmission, providing the intracellular transport of synaptic vesicles, neurotransmitters and receptors (Tiedge et al 2001;Mizuno et al 2004). The contribution of microtubule motor proteins to synaptic plasticity has been observed during long-term potentiation in the hippocampus and long-term facilitation of the gill-withdrawal reflex in Aplysia (Collingridge et al 2004;Puthanveettil et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Habituation-Like Decrease of Acetylcholine-Induced Inward Current in Helix Command Neurons: Role of Microtubule Motor Proteins

2015

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The role of kinesin and dynein microtubuleassociated molecular motors in the cellular mechanism of depression of acetylcholine-induced inward chloride current (ACh-current) was examined in command neurons of land snails (Helix lucorum) in response to repeated applications of ACh to neuronal soma. This pharmacological stimulation imitated the protocol of tactile stimulation evoking behavioural habituation of the defensive reaction.In this system, a dynein inhibitor (erythro-9-(2-hydroxy-3-nonyl)adenine, 50 lM) decreased the ACh-current depression rate. Kinesin Eg5 inhibitors (Eg5 inhibitor III, 10 lM and Eg5 inhibitor V, trans-24, 15 lM) reduced the degree of current depression, and Eg5 inhibitor V also reduced the initial rate of depression. The results of electrophysiological experiments in combination with mathematical modelling provided evidence of the participation of dyneins and kinesin Eg5 proteins in the radial transport of acetylcholine receptors in command neurons of H. lucorum in the cellular analogue of habituation. Furthermore, these results suggest that the reciprocal interaction between dynein and kinesin proteins located on the same vesicle can lead to reverse their usual direction of transport (dyneins-in exocytosis and kinesin Eg5-in endocytosis).Keywords EHNA Á Eg5-inhibitor-III Á Eg5-inhibitor-V trans-24 Á Short-term depression of ACh-induced chloride current Á Command neurons Á Helix lucorum Á Habituation

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Molecular kinesis in cellular function and plasticity

Cited by 7 publications

References 22 publications

Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling

Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling

Neuroplasticity in Alzheimer's disease

Habituation-Like Decrease of Acetylcholine-Induced Inward Current in Helix Command Neurons: Role of Microtubule Motor Proteins

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