Molecular-level insights into aging processes of skin elastin

Huertas, Angela C. Mora; Schmelzer, Christian E.H.; Hoehenwarter, Wolfgang; Heyroth, Frank; Heinz, Andrea

doi:10.1016/j.biochi.2016.08.010

Cited by 105 publications

(96 citation statements)

References 48 publications

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“…Several hypotheses, such as oxidative stress, DNA damage, telomere shortening, or inflammaging, could influence the skin aging process (Zhang and Duan, 2018). Distribution of collagen, elastin, or proteoglycans in the extracellular matrix can affect the tensile strength, elasticity, and hydration of the aged skin (Mora Huertas et al, 2016). Wilke et al (2019) described an age-related modification in fascia thickness as older participants showed higher thickness in the lumbar spine than younger participants.…”

Section: Pmas and Agingmentioning

confidence: 99%

Effect of Age and Body Size on the Wrist's Viscoelasticity in Healthy Participants From 3 to 90 Years Old and Reliability Assessment

Nguyen

Herman

Mahaudens

et al. 2020

Front. Sports Act. Living

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Excessive or insufficient levels of passive musculoarticular stiffness (PMAS) can lead to joint impairment or instability. Quantifying the PMAS may provide a better understanding of neurological or musculoskeletal disorders. The aims of the present study were multiple: first, to assess the reliability of quantifying PMAS and to collect normative data on the wrist in healthy participants, and second, to assess the effect of age and body size on PMAS. For this purpose, a total of 458 participants from 3 to 90 years old were analyzed with an electromechanical oscillation device (EOD). Passive sinusoidal movements were induced in a flexion/extension pattern in the participants' wrists, enabling an objective measurement of elastic stiffness (EL) and viscous stiffness (VI). Both the dominant and non-dominant wrists were assessed. Two-way repeated-measures ANOVA revealed a sex differentiation from puberty (12-18 years old) and an increase of EL and VI from childhood to adulthood and a decrease of stiffness at old age. EL and VI values were associated with body size characteristics and age. After body size normalization, EL was no longer influenced by the variables measured. On the other hand, VI remained moderately influenced by age and body size. The current study was able to provide normative data of PMAS in the wrist of healthy participants.

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Section: Pmas and Agingmentioning

confidence: 99%

Effect of Age and Body Size on the Wrist's Viscoelasticity in Healthy Participants From 3 to 90 Years Old and Reliability Assessment

Nguyen

Herman

Mahaudens

et al. 2020

Front. Sports Act. Living

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“…These symptoms often lead individuals to pursue body contouring surgery (BCS) after bariatric surgery [4]. Although adolescents undergoing bariatric surgery achieve similar weight loss and health improvement compared with adults [5], they may be less susceptible to problems associated with excess skin and soft tissue than adults due to greater skin thickness and elasticity [6]. However, contrasting data suggest that some adolescents experience dissatisfaction with excess skin and a desire for BCS comparable with that in adults [7].…”

mentioning

confidence: 99%

Body contouring in adolescents after bariatric surgery

Derderian

Patten

Kaizer

et al. 2020

Surgery for Obesity and Related Diseases

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Background: Bariatric surgery leads to sustained weight loss and resolution of obesity-associated co-morbidities in severely obese adolescents. However, one consequence of massive weight loss is excess skin and soft tissue. Many details regarding the timing, outcomes, and barriers associated with body contouring surgery (BCS) in youth who have undergone bariatric surgery are unknown. Objectives: Describe the incidence and effect of BCS following bariatric surgery among adolescents. Setting: University Hospitals. Methods: Teen-Longitudinal Assessment of Bariatric Surgery is a prospective multi-institutional study of 242 adolescents who underwent bariatric surgery from 2007 to 2012. Utilization of BCS was analyzed in this population with comparison of anthropometrics and excess skin-related symptoms between those who did and those who did not undergo BCS. Results: Among the 198 study participants with BCS data available, 25 (12.6%) underwent 41 body contouring procedures after bariatric surgery. The most common BCS was panniculectomy (n 5 23). Presence of pannus-related symptoms at baseline and the magnitude of weight loss within the first year after bariatric surgery were independently associated with subsequent panniculectomy (P 5.04 and P 5.03, respectively). All adolescents who underwent panniculectomy experienced resolution of pannus-related symptoms. At 5 years after bariatric surgery, 74% of those who did not undergo panniculectomy reported an interest in the procedure, and 58% indicated that cost/insurance coverage was the barrier to obtaining BCS. Conclusion: Few adolescents who underwent bariatric surgery later underwent BCS procedures. Panniculectomy effectively treated pannus-related symptoms. Disparities in access to surgical care for adolescents who desire BCS warrants further investigation.

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“…Therefore, these aging processes are accompanied by the phenotypic exchange in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagen, elastin, and proteoglycans, which are necessary to provide tensile strength, elasticity, and hydration to skin respectively. 11 Also, they cause laxity and fragility of skin with reduced collagen syntheses and enzymatic degradation. 12 The degree of skin photoaging could be classified by Fitzpatrick skin types I to IV according to its severity from few wrinkles to deep wrinkles.…”

Section: Skin Aging Phenomenamentioning

confidence: 99%

Assessment of Laser Effects on Skin Rejuvenation

et al. 2020

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Laser skin resurfacing has changed the approach of facial skin rejuvenation over the past decade. This article evaluates the laser effects on skin rejuvenation by the assessment of laser characteristics and histological and molecular changes, accompanied by the expression of proteins during and after laser-assisted rejuvenation of skin. It is important to note that different layers of skin with different cells are normally exposed to the sun’s UV radiation which is the most likely factor in aging and damaging healthy skin. To identify the expression of proteins, using validated databases and reviewing existing data could reveal altered proteins which could be analyzed and mapped to investigate their expression and their different effects on cell biological responses. In this regard, proteomics data can be used for better investigation of the changes in the proteomic profile of the treated skin. Different assessments have revealed the survival and activation of fibroblasts and new keratinocytes with an increase of collagen and elastin fibers in the dermis and the reduction of matrix metalloproteinases (MMPs) and heat shock proteins (HSPs) as a result of different lowpower laser therapies of skin. There are a wide range of biological effects associated with laser application in skin rejuvenation; therefore, more safety considerations should be regarded in the application of lasers in skin rejuvenation.

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Molecular-level insights into aging processes of skin elastin

Cited by 105 publications

References 48 publications

Effect of Age and Body Size on the Wrist's Viscoelasticity in Healthy Participants From 3 to 90 Years Old and Reliability Assessment

Effect of Age and Body Size on the Wrist's Viscoelasticity in Healthy Participants From 3 to 90 Years Old and Reliability Assessment

Body contouring in adolescents after bariatric surgery

Assessment of Laser Effects on Skin Rejuvenation

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