Molecular “light switch” for G-quadruplexes and i-motif of human telomeric DNA: [Ru(phen)2(dppz)]2+

Shi, Shuo; Zhao, Juan; Geng, Xiao-Ting; Yao, Tianming; Huang, Hailiang; Liu, Tianlin; Zheng, Leng-Feng; Li, Zonghui; Yang, Danjing; Ji, Liang‐Nian

doi:10.1039/b916094a

Cited by 84 publications

(50 citation statements)

References 40 publications

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“…This sequence was chosen for its ability to form both double-stranded B-DNA and Holliday junctions (25)(26)(27). Given recent literature reports demonstrating the ability of ruthenium polypyridyl complexes to bind to secondary structures of nucleic acids other than duplexes, such as quadruplex DNA and i-motif conformations (28), bulges and loops, etc. (29), we were intrigued to see how ½RuðTAPÞ 2 ðdppzÞ 2þ would bind to this oligonucleotide.…”

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confidence: 99%

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Hall

O'Sullivan

Naseer

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

129

140

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We describe a crystal structure, at atomic resolution (1.1 Å, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51°kinking of the double helix. The complex cation Λ-½Ruð1,4,5,8-tetraazaphenanthreneÞ 2 ðdipyridophenazineÞ 2þ crystallizes in a 1∶1 ratio with the oligonucleotide d(TCGGCGCCGA) in the presence of barium ions. Each complex binds to one duplex by intercalation of the dipyridophenazine ligand and also by semiintercalation of one of the orthogonal tetraazaphenanthrene ligands into a second symmetrically equivalent duplex. The result is noncovalent cross-linking and marked kinking of DNA.DNA oligonucleotide | ruthenium complex | X-ray crystal structure

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mentioning

confidence: 99%

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Hall

O'Sullivan

Naseer

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

129

140

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“…the ruthenium complex 34, reported by Shi, which has been shown to interact strongly (K = 5.2 Â 10 6 for the hybrid topology of human telomeric with quadruplex DNA) via p-p end-stacking interactions. 82 Interestingly this study shows that the ruthenium complex is selective for G-quadruplex DNA over i-motif DNA (another tetra-stranded topology of DNA formed when C-rich strands self-associate at acidic or neutral pH into a structure based on intercalated C-C + base pairs). In addition, the complex, which is non fluorescent in aqueous medium, becomes emissive upon binding to quadruplex DNA.…”

Section: 33mentioning

confidence: 96%

Interaction of metal complexes with nucleic acids

Suntharalingam

Vilar

2011

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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This chapter, divided into three sections, reviews the literature reported during 2010 in the field of interaction of metal complexes with nucleic acids and complex formation between metals and coordinating moieties within nucleic acids. The first two sections focus on the interaction of metal complexes and ions with DNA and RNA, respectively, and are organised by mode of interaction. In the last section examples where transition metals occupy coordination sites covalently incorporated within nucleic acids strands' are discussed. HighlightsA series of achiral copper(II) complexes, when bound to duplex DNA, perform catalytic enantioselective hydration of enones. 1 The X-ray structure of a RNA polymerase II transcribing complex stalled at the monofunctional pyriplatin site has been resolved, providing an insight into the mechanism of transcription inhibition. 2 The first structural characterisation of a nucleic acid with a continuous run of metal modified base pairs has been reported. 3 A polyacrylamide hydrogel functionalised with a thymine rich DNA strand has been developed to detect and simultaneously remove toxic Hg II ions from water. 4 The first gold complex to interact with quadruplex DNA has been reported. 5 Cu II -salen metal-base pairs have been introduced inside the double helix of DNA; the stacked copper(II) square planar complexes display antiferromagnetic coupling. 6 Interaction of metal centres with DNAIn this section, the material has been organised by binding type; direct base coordination of the metal centre or non-covalent interactions such as intercalation, hydrogen bonding or electrostatic interactions.

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“…More recently, transition metal complexes have been explored as selective probes for DNA, in particular the G-quadruplex DNA structure 27–33. Transition metal complexes have several useful qualities for this application.…”

Section: Introductionmentioning

confidence: 99%

Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior

et al. 2016

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Molecular “light switch” for G-quadruplexes and i-motif of human telomeric DNA: [Ru(phen)2(dppz)]2+

Abstract: [Ru(phen)(2)(dppz)](2+)can serve as a prominent molecular "light switch" for G-quadruplexes and i-motif, but it preferentially binds to G-quadruplexes over i-motif.

Cited by 84 publications

References 40 publications

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

Interaction of metal complexes with nucleic acids

Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior

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