Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

Skotland, Tore; Ekroos, Kim; Kauhanen, Dimple; Simolin, Helena; Seierstad, Therese; Berge, Viktor; Sandvig, Kirsten; Llorente, Alicia

doi:10.1016/j.ejca.2016.10.011

Cited by 283 publications

(244 citation statements)

References 52 publications

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“…Specifically, it was found that exosomes secreted from the prostate cancer, PC‐3 cell line, possess approximately 280 lipid species from 18 lipid classes . In addition, the recent studies executed with 15 prostate cancer patients and 13 healthy controls, clearly demonstrated that the level of sphingolipids are substantially higher in the prostate cancer patients than in the healthy controls . Overall, these results confirm that the exosome lipids like nucleic acids and proteins can serve as the biomarker for the diagnosis of cancers …”

Section: Exosome As a Biomarker Reservoirsupporting

confidence: 67%

Exosomes for Non‐Invasive Cancer Monitoring

Kalishwaralal

Kwon

Park

2018

Biotechnology Journal

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Exosomes, membrane‐bound phospholipid vesicles having diameters of 50–200 nm, are secreted by all cell types and circulate in human body fluids. These vesicles are known to carry cellular constituents that are specific to the originating cells (e.g., cytoplasmic/membrane proteins, RNA, and DNA). Thus, exosomes, which are both structurally stable and abundant, are robust indicators of cancers and, as a result, they have been utilized to monitor this disease in a manner that is less invasive than gold standard tissue biopsies. In this review, the history of exosomes and the specific biomarkers present in exosomes that enable accurate monitoring of various diseases are described. In addition, methods for analysis of exosomes and identification of biomarkers are presented with special emphasis being given to isolation and signaling strategies. Lastly, integrated, microfluidic systems developed for exosome‐based cancer diagnosis are described and future directions that research in this area will likely take are presented.

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Section: Exosome As a Biomarker Reservoirsupporting

confidence: 67%

Exosomes for Non‐Invasive Cancer Monitoring

Kalishwaralal

Kwon

Park

2018

Biotechnology Journal

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“…Despite the proposed shorthand notation, there has been a mix of annotation styles present in literature. For example, of the lipidomics research articles published in 2017 determined on Science Direct (accessed 02/09/2017), 3 articles [29,32,33] incorrectly used “/”, 3 articles [34–36] used “-”, and1article [37] used “_” between fatty acyl constituents, when positional isomers were not identified. One potential source of confusion in annotating lipids is that current lipid identification software, for example LipidSearch, MS-DIAL [38], LipidBlast [39], and Greazy [40] all employ “/”when fatty acyl positions are not known.…”

Section: Introductionmentioning

confidence: 99%

Common cases of improper lipid annotation using high-resolution tandem mass spectrometry data and corresponding limitations in biological interpretation

Koelmel

Ulmer

Jones

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Common tumor‐related exosome ingredients including RNA and protein are not availably detected in prostate cancer, other exosomal ingredients, like small metabolites, are significantly lower in urine from prostate cancer patients . Similarly, the high‐level of exosome lipids in urine is also remarkably different, which has the value of diagnosing prostate cancer . Further researches focusing on intrinsically bioactive ingredients loaded by exosomes might offer a unique avenue on tumor aggressiveness and concomitantly enhance our understanding of potentially harmful factors in cancer patients.…”

Section: The Clinical Applications Of Tumor Exosomesmentioning

confidence: 99%

The cancer exosomes: Clinical implications, applications and challenges

Tang

Hou

et al. 2019

Intl Journal of Cancer

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The exosome is a small functional vesicle enriched in selected proteins, lipids and nucleic acids, displaying distinct molecular heterogeneity. Exosomes released can transform the extracellular matrix microenvironments, transmit signals and molecules to recipient cells and trigger changes in their pathophysiological functions. Tumor‐derived exosomes mediate the interactions of tumor cells and microenvironment significantly, and they stimulate tumor growth and development through specific signaling pathways related to metastasis, therapeutic resistance and immunosuppression. Exosome biogenesis from tumors often represents abundant biological information, and novel and efficient isolation and detection methods of exosomes provide a promising approach for tumor diagnosis and prognosis estimation. Moreover, exosome can even be developed as therapeutic agents for multiple disease models based on effective material transport characteristics and biofilm specificity. This review reports the clinical implications and challenges of exosomes in cancer progression, therapy resistance, metastasis and immune escape, and underlying cancerogenic pathological phenotypes including fibrosis and viral infection.

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Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers

Cited by 283 publications

References 52 publications

Exosomes for Non‐Invasive Cancer Monitoring

Exosomes for Non‐Invasive Cancer Monitoring

Common cases of improper lipid annotation using high-resolution tandem mass spectrometry data and corresponding limitations in biological interpretation

The cancer exosomes: Clinical implications, applications and challenges

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