Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes

González‐Pérez, Ruperto; Poza‐Guedes, Paloma; Pineda, Fernando; Galán, Tania; Mederos-Luís, Elena; Abel-Fernández, Eva; Martínez, María José Fresnadillo; Sánchez‐Machín, Inmaculada

doi:10.3390/ijms241310467

Cited by 6 publications

(4 citation statements)

References 68 publications

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“…Precisely defining the external exposome on a molecular level, along with its potential significance as a clinically significant allergen, is crucial for understanding the diverse range of phenotypes within atopic conditions. This understanding can contribute to personalized diagnoses and treatment approaches [ 73 ]. Figure 2 .…”

Section: Discussionmentioning

confidence: 99%

The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

Indolfi,

D’Addio,

Bencivenga

et al. 2023

Life

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The current literature shows mixed results relating to the significance of environmental exposure, such as owning a pet, and the development of atopy in children. Our review aimed to collect the most recent evidence on the association between early-life cat and dog ownership and the development of allergy and asthma. A comprehensive literature review was performed using PubMed and Scopus. The search included the main keywords of our PICO: (((early exposure) AND (children) AND (allergy)) OR (asthma)) AND (dog) OR (cat). Randomized controlled trials (RCTs), case–control studies, clinical trials, meta-analyses, and systematic reviews of children within the last five years (2018–2023) were searched and included. During the search process, 52 articles from PubMed and 43 from Scopus were found. A total of 17 articles were deemed to be suitable and included. Fairly consistent results regarding early exposure to pets, in particular dogs, and the prevention of food allergies have been described. Furthermore, there seems to be a protective effect against allergy and asthma in relation to the number of pets owned. The likelihood of a child developing allergy and asthma seems to be influenced by various factors, including the child’s genetic background and early exposure to different environmental factors, including allergens that may interact with the gut microbiota and immune system.

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Section: Discussionmentioning

confidence: 99%

The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

Indolfi,

D’Addio,

Bencivenga

et al. 2023

Life

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“…This heterogeneity should be considered in the diagnosis and treatment of HDM-allergic patients.To this end, several studies have been proposed to understand the molecular exposome of the different regions, and to evaluate how the molecules of an allergenic source may influence the allergic pathology of the patients under study ( 15 , 28 , 30 , 31 ). Gonzalez-Pérez et al ( 32 ) described on a regional scale different patterns of molecular reactivity dependent on climate and other factors, in which the allergens Der p 21, Der p 5 and Der p 7 also appeared as serodominant molecules, in addition to the highly prevalent IgE responses to major HDM allergens, especially in subjects with asthma and atopic dermatitis.…”

Section: The Patientmentioning

confidence: 99%

360° approach to the patient with mite allergy: from scientific evidence to clinical practice

Nieto-García,

Abel-Fernández,

Nieto-Cid

et al. 2024

Front. Allergy

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In the recent years, several important advances have been made in the diagnosis of allergy using molecular techniques. The aetiological diagnosis of allergy using molecular components of allergens allows a more precise definition of the patient's IgE repertoire. Precision medicine is a structural model aimed at personalising healthcare and places the patient at the centre of the specialist's decision-making process. To this end, an accurate characterisation of the external exposome at a molecular level and their putative role as clinically relevant allergens is essential to elucidate the phenotypic diversity of atopic disease, with a view to personalising diagnosis and therapy. It has been proposed a decision algorithm, the Top-Down approach, where the clinical history is set first and is followed by the use of skin tests or specific IgE techniques, which facilitates the clinicians to make decisions. The therapeutic intervention driven by the standard diagnostic approach, but supported by these innovative tools, can lead to a better phenotyping of highly complex patients, and a more appropriate prescription of AIT. To this end, the allergen extracts used for diagnosis require to be of proven quality and contain the most relevant allergens. Likewise, allergen vaccines must gather efficacy, safety, duration, and patient compliance, hence the demand for new vaccines to overcome these drawbacks.

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“…The primary objective of this post-hoc analysis [7] was to comprehensively evaluate the current eligibility status for house dust mite (HDM) AIT within a selected cohort of young individuals who manifest diverse atopic phenotypes. Through a PAMD@ approach, we sought to discern the appropriateness of initiating HDM AIT in this specific group, considering the varied atopic profiles present among these individuals.…”

Section: Introductionmentioning

confidence: 99%

Advocacy of Precision Allergy Molecular Diagnosis in Decision Making for the Eligibility of Customized Allergen Immunotherapy

González-Pérez,

Poza-Guedes,

Pineda

et al. 2023

CIMB

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Allergen immunotherapy (AIT) with aeroallergens is the only disease-modifying treatment for patients with different allergic conditions. Despite the effectiveness of AIT having been proven in both randomized controlled trials and real-world studies, it remains underused in less than 10% of subjects with allergic rhinitis (AR) and/or asthma (A). We aimed to determine the current eligibility for house dust mite (HDM) AIT by means of a precision allergy molecular diagnosis (PAMD@) model in a selected cohort of youngsters with different allergic phenotypes according to the available evidence. A complex response to both HDM and storage mite allergens was depicted regardless of the subjects’ basal atopic condition. No solely specific IgE-binding responses to Der p 1, Der p 2, and/or Der p 23 were found in the studied cohort. Despite the patients with A and atopic dermatitis showing significantly higher serum titers to six mite allergens than subjects with AR, no specific molecular profile was regarded as disease specific. Given the increasing complexity of specific IgE responses to the local prevailing aeroallergens, the identification and presence of such molecules are needed in commercially available AIT in the era of precision medicine.

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Molecular Mapping of Allergen Exposome among Different Atopic Phenotypes

Cited by 6 publications

References 68 publications

The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

360° approach to the patient with mite allergy: from scientific evidence to clinical practice

Advocacy of Precision Allergy Molecular Diagnosis in Decision Making for the Eligibility of Customized Allergen Immunotherapy

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