Molecular markers are predictors of recurrence and survival in patients with Dukes B and Dukes C colorectal adenocarcinoma

Abstract

Besides Dukes stage, multivariate analysis of all the studied molecular markers showed that patients expressing CD44 and cytokeratin-19 had a significantly reduced relapse-free and poor overall survival. Moreover, patients expressing both these markers (CD44 and cytokeratin-19) had the lowest significant relative risk for developing recurrence than patients with both markers negative when treated with surgery followed by adjuvant chemotherapy as compared with patients treated with surgery alone. Thus, in patients with colorectal cancer, immunohistochemical localization of CD44 and cytokeratin-19 may be included as a part of routine pathologic evaluation along with conventional prognostic factors.

Clinicopathological significance of prolactin receptor expression in colorectal carcinoma and corresponding metastases

“…20,[27][28][29][30][31][32] Of note, compared with normal colorectal tissue, cancer tissues show a significantly higher rate of co-expression of prolactin and its receptor. Thus, in addition to systemic effects, prolactin presumably acts through an auto-/paracrine loop in promoting cell proliferation, as shown in colorectal cancer cell lines (CaCO-2, HT-29, and LoVo cells).…”

Expression of cytokeratin-19 (CK19) in the classical subtype of papillary thyroid carcinoma: the experience of one center in the Silesian region

“…Soluble fragments of CK19 can be detected with ELISA using the CYFRA 21-1 assay [19]. CK19 is observed in the ductal epithelium of the pancreas and bile duct, and very often is considered a biomarker of hepatocellular carcinoma, PTC, squamous cell carcinoma, and large bowel adenocarcinoma [20][21][22][23]. Jain et al [24] pointed to CK19 as an independent prognostic factor for neuroendocrine tumors of the pancreas.…”

Imunoexpressão do receptor do fator de crescimento epidérmico (EGFR) nos tecidos neoplásicos e adjacentes do carcinoma colorretal esporádico

“…Diversos marcadores teciduais são descritos na literatura, porém poucos apresentam relevância quanto à condução clínica do paciente 7,8 .…”

“…Idealmente, nas neoplasias colorretais, os marcadores teciduais deveriam alterar-se com o estádio do tumor, servir como exame prognós-tico e auxiliar na definição da necessidade de realização de terapêutica complementar 7,[9][10][11][12] . Mesmo nos enfermos submetidos à ressecção da doença primária com intenção curativa, a recidiva neoplásica pós-operatória é uma frequente causa de óbito [13][14][15] .…”