Molecular markers in dysplasia of the larynx: expression of cyclin-dependent kinase inhibitors p21, p27 and p53 tumour suppressor gene in predicting cancer risk

Jeannon, Jean Pierre; Soames, J.V.; Aston, Val; Stafford, F. W.; Wilson, Janet A.

doi:10.1111/j.1365-2273.2004.00859.x

Cited by 29 publications

(36 citation statements)

References 19 publications

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“…In a study of 114 cases of untreated dysplasia of the larynx, Jeannon et al [21] found that expression of p53 was not associated with cancer progression. In their study, Hirai et al [14] revealed that p53 immunostaining was observed in 6 out of 20 cases of hyperplasia, 3 out of 19 cases of dysplasia and 7 out of 17 cases of carcinoma, no significant association was found between p53 and the histopathological findings.…”

Section: Discussionmentioning

confidence: 99%

Ki67, p27 and p53 Expression in Squamous Epithelial Lesions of Larynx

Mondal¹,

Kaushik

Datta

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Precise assessment of the biological behavior and progression of squamous epithelial lesions of the larynx with a view to predict the prognosis and therapeutic challenges remains an elusive goal. The knowledge and data regarding the expression of proliferative markers indicating the biological activity in different histological grades of squamous epithelial lesions are lacking till date. To evaluate the relationship between Ki67, p27 and p53 expression as well as topographic distribution of Ki67 with the histological subtypes or grades of laryngeal squamous intraepithelial and invasive lesions. Sixty-two consecutive cases with histologically documented intraepithelial and invasive squamous lesion were studied for Ki67, p27 and p53 expression. MannWhitney U, Kruskal-Wallis and Spearman's correlation tests were used for statistical analysis. The mean Ki67 labeling index in hyperplasia, dysplasia and carcinoma were 12.15, 22.03 and 35.53 % respectively and this difference was statistically significant (P \ 0.05). There was strong positive correlation between Ki67 labeling index and increasing grades of squamous lesions. p27 expression was progressively decreased and p53 expression was progressively increased as the lesions progressed from hyperplasia to dysplasia and dysplasia to carcinoma. The topographic distribution of Ki67 positive cells increased with progressive grades of dysplasia. The Ki67 labeling index correlates well with the histological grade of both intraepithelial and invasive lesions of the larynx. And the topographic distribution of Ki67 expression depends on the grade of the dysplasia. Hence, Ki67 expression has a definite role in predicting the biological behavior of the lesions.

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Section: Discussionmentioning

confidence: 99%

Ki67, p27 and p53 Expression in Squamous Epithelial Lesions of Larynx

Mondal¹,

Kaushik

Datta

et al. 2012

Indian J Otolaryngol Head Neck Surg

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“…More precisely, p16 (p16INK4A) was analyzed in a case-control study where reduction of p16 expression tended to be more frequent in cases than in controls [25]. p21 and p27 expression was assessed in a retrospective study, but none of these proteins were associated with malignant progression [17].…”

Section: Cell Cycle Regulatorsmentioning

confidence: 99%

“…Most studies investigate the inactivation of the TP53 gene by immunohistochemical analysis of p53 protein levels, in light on the fact that the half-life of the wild-type protein is too short to permit its detection, while the mutant protein is stable. The p53 protein expression as a biomarker of laryngeal cancer risk has been assessed in four retrospective studies [13,[15][16][17] and three case-control studies [23][24][25]. These studies used different scoring systems for p53 staining, which prevents a direct comparison of the results.…”

Section: Cell Cycle Regulatorsmentioning

confidence: 99%

Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

Rodrigo

Suárez

Takes

et al. 2011

Eur Arch Otorhinolaryngol

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Some laryngeal epithelial precursor lesions progress to invasive carcinoma and others do not. Routine light microscopic classification has limited value in predicting the evolution of these lesions. This article reviews the experience to date with the use of molecular markers for the prognostic evaluation of laryngeal epithelial precursor lesions. We conducted a thorough review of the published literature to identify those studies using biomarkers to predict malignant progression of laryngeal epithelial precursor lesions. Of the 336 studies identified in this systematic search, 15 met the inclusion criteria and form the basis of this review. Limited studies suggest that certain biomarkers are potentially reliable predictors of malignant progression including various regulators of cell adhesion and invasion (e.g. FAK, cortactin, osteopontin, and CD44v6) and proliferation-associated markers such as TGF-βRII and Kv3.4. The predictive value of these markers, however, has yet to be confirmed in large-scale prospective studies. Although the cell cycle-related proteins are the most frequently studied markers, none have been consistently reliable across multiple studies. The absence of standardization in methodologies, test interpretation, and other parameters may contribute to study inconsistencies. Various biomarkers have proved to have potential prognostic value and could be clinically relevant. The utility and prognostic power of these biomarkers should be confirmed in large, well-designed, standardized prospective studies.

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“…Several studies of OIN generally agree that the severity of epithelial abnormality reflects the degree of risk of SCC development (Jeannon et al 2004). No marker or group of markers has so far been identified as a reliable predictor of malignant progression of SILs.…”

Section: Additional Markers Of Malignant Alterations Of Oral Intraepimentioning

confidence: 99%

“…The grades do not offer clear therapeutic guidelines to clinicians for appropriate management. For CIS at least, the WHO grading system diagnoses CIS showing maturation and differentiation as lower risk lesions, and these lesions account for a large proportion of cases in the oral mucosa (Hellquist et al 1982;Gillis et al 1983;Yoo et al 2004;Kleist&Poetsh 2004;Jeannon et al 2004;Chi et al 2004).…”

Section: Who Classificationmentioning

confidence: 99%