Molecular Markers in the Pathogenesis of Cholangiocarcinoma: Potential for Early Detection and Selection of Appropriate Treatment

Braicu, Cornelia; Burz, Claudia; Berindan‐Neagoe, Ioana; Bălăcescu, Ovidiu; Tanţău, Marcel; Cristea, Victor; Irimie, Alexandru

doi:10.4021/gr2009.06.1299

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…Another suggested mechanism is the inflammatory molecules. Multiple inflammatory cytokines were found to be elevated in obesity including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and both were found to promote cholangiocarcinoma growth [11,[35][36][37].…”

Section: Obesity and Cholangiocarcinomamentioning

confidence: 99%

Controversial risk factors for cholangiocarcinoma

Baidoun¹,

Sarmini

Merjaneh³

et al. 2021

European Journal of Gastroenterology &Amp; Hepatology

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We did a cross-section study using the National Inpatient Sample (NIS) database between 2011 and 2015. The NIS database is the largest all-payer inpatient database in the United States and contains a sample of over eight million inpatient hospitalizations each year, which represents about 20% of all the discharges from all community hospitals participating in the Healthcare Cost and Utilization Project (HCUP). It excludes rehabilitation and long-term acute care hospitals. Each record of the NIS data includes up to 25 primary and secondary diagnoses in addition to up to 15 primary and secondary procedures. It also has the patient demographics, discharge status, length of stay, disease severity and comorbidity measures. Study population, inclusion and exclusion criteriaAll adult patients (≥18 years old) from the NIS database between 2011 and 2015 were included. Using the International Classification of Diseases 9th version (ICD-9) code, we identified all records with cholangiocarcinoma using the appropriate codes. We identified patients' demographics using the Clinical Classification Software codes provided by the HCUP and appropriate ICD-9 codes. Using appropriate ICD-9 codes and Elixhauser comorbidity, we also identified the comorbidities of interest as shown in Supplementary Table 1 and 2, Supplemental digital Introduction Cholangiocarcinoma is a rare malignancy accounting for 3% of gastrointestinal cancers in the USA. While multiple risk factors for cholangiocarcinoma are established, other potential risk factors are still controversial. Herein, we used a large national database to investigate possible risk factors and associations. Method We used the National Inpatient Sample database to review all admissions between 2011 and 2015. We grouped patients based on the presence and absence of cholangiocarcinoma. Using multivariate logistic regression analysis, we assessed the association between obesity, alcohol abuse, smoking, diabetes mellitus and cholangiocarcinoma. Results Out of 30 9552 95 admissions, 20 030 had cholangiocarcinoma. Cholangiocarcinoma patients were older (67 ± 12.8 vs. 57 ± 20.6; P < 0.001) and had fewer female patients (48 vs. 59%; P < 0.001). Multivariate logistic regression analysis showed that diabetes mellitus was associated with cholangiocarcinoma (OR, 1.04; 95% CI, 1.01-1.08; P < 0.001). On the other hand, alcohol, smoking and obesity were all inversely associated with cholangiocarcinoma (OR, 0.75; 95% CI, 0.69-0.81; P < 0.001), (OR, 0.75; 95% CI, 0.71-0.79; P < 0.001) and (OR, 0.71; 95% CI, 0.67-0.75; P < 0.001), respectively. In addition, compared to Whites, Hispanic and Asian/Pacific Islander races were more associated with cholangiocarcinoma (OR, 1.27; 95% CI, 1.21-1.34) and (OR, 1.79; 95% CI, 1.67-1.92) (P < 0.001 for all), respectively, whereas African American race was inversely associated with cholangiocarcinoma (OR, 0.85; 95% CI, 0.81-0.89; P < 0.001). Conclusion Patients with a diagnosis of diabetes mellitus or from certain ethnic groups (Hispanic and Asian/Pacific Islander) ar...

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Section: Obesity and Cholangiocarcinomamentioning

confidence: 99%

Controversial risk factors for cholangiocarcinoma

Baidoun¹,

Sarmini

Merjaneh³

et al. 2021

European Journal of Gastroenterology &Amp; Hepatology

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“…In 2016, it is estimated that more than 35,000 people in the U.S alone will be diagnosed with HCC. This number has been steadily increasing by about 3–4% annually over the last 10 years; overall, the incidence has tripled since the 1980s [ 55 , 56 ]. Viral hepatitis was once the leading cause of HCC worldwide.…”

Section: Hepatocellular Cancermentioning

confidence: 99%

“…Studies have demonstrated that serum leptin levels are increased in obesity and have been suggested as a risk factor for CC [ 66 ]. Besides leptin, other pro-inflammatory cytokines - Interleukin-6 (IL-6) and tumor necrosis factor (TNF) are linked strongly to obesity and have been found to have a role in development of CC [ 56 ]. Based on the current literature review, evidence of association of obesity with CC is growing and needs to be confirmed with long-term cohort studies.…”

Section: Cholangiocarcinomamentioning

confidence: 99%

A review of the impact of obesity on common gastrointestinal malignancies

Krishna

Hussan

Cruz‐Monserrate

et al. 2017

Integr Cancer Sci Therap.

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Obesity is a global pandemic and is a well-recognized risk factor for various gastrointestinal diseases. The prevalence of obesity is increasing across all age groups. There is an emergent need for focused guidelines aimed at reducing the incidence, prevalence, and associated risks of obesity. The impact of obesity on gastrointestinal cancers being multifactorial adversely influences the associated risk, disease course, prognosis, and overall survival. We have summarized the current literature highlighting the association between obesity and common gastrointestinal cancers, with specific focus on esophageal adenocarcinoma, colon cancer, hepatocellular cancer, cholangiocarcinoma, and pancreatic malignancies.

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Expression of Molecular Differentiation Markers Does Not Correlate with Histological Differentiation Grade in Intrahepatic Cholangiocarcinoma

et al. 2016

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The differentiation status of tumor cells, defined by histomorphological criteria, is a prognostic factor for survival of patients affected with intrahepatic cholangiocarcinoma (ICC). To strengthen the value of morphological differentiation criteria, we wished to correlate histopathological differentiation grade with expression of molecular biliary differentiation markers and of microRNAs previously shown to be dysregulated in ICC. We analysed a series of tumors that were histologically classified as well, moderately or poorly differentiated, and investigated the expression of cytokeratin 7, 19 and 903 (CK7, CK19, CK903), SRY-related HMG box transcription factors 4 and 9 (SOX4, SOX9), osteopontin (OPN), Hepatocyte Nuclear Factor-1 beta (HNF1β), Yes-associated protein (YAP), Epithelial cell adhesion molecule (EPCAM), Mucin 1 (MUC1) and N-cadherin (NCAD) by qRT-PCR and immunostaining, and of miR-31, miR-135b, miR-132, miR-200c, miR-221 and miR-222. Unexpectedly, except for subcellular location of SOX9 and OPN, no correlation was found between the expression levels of these molecular markers and histopathological differentiation grade. Therefore, our data point toward necessary caution when investigating the evolution and prognosis of ICC on the basis of cell differentiation criteria.

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Molecular Markers in the Pathogenesis of Cholangiocarcinoma: Potential for Early Detection and Selection of Appropriate Treatment

Cited by 4 publications

References 46 publications

Controversial risk factors for cholangiocarcinoma

Controversial risk factors for cholangiocarcinoma

A review of the impact of obesity on common gastrointestinal malignancies

Expression of Molecular Differentiation Markers Does Not Correlate with Histological Differentiation Grade in Intrahepatic Cholangiocarcinoma

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