Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage

Kim, Seong–Min; Kim, Sung Woo; Han, Sang Jun; Lee, Sanghoon; Park, Hyun Tae; Song, Jae Yun; Kim, Tak

doi:10.3390/ijms22147484

Cited by 51 publications

(39 citation statements)

References 253 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oocytes and granulosa cells are vulnerable to chemotherapeutic agents. The possible gonadotoxic chemotherapeutic agents used are shown in Table 2 [7]. Each agent has a different mechanism of action on malignant cells, resulting in the cessation of the cell cycle.…”

Section: Mechanism Of Chemotherapy-induced Ovarian Damagementioning

confidence: 99%

“…Each agent has a different mechanism of action on malignant cells, resulting in the cessation of the cell cycle. With conventional chemotherapy agents, ovarian insufficiency involves PF pool depletion by apoptosis or hyperactivation mechanisms, mediated by the ABL/TAp63 and PI3K/Akt/mTOR pathways [7].…”

Section: Mechanism Of Chemotherapy-induced Ovarian Damagementioning

confidence: 99%

“…Traditional biochemical markers for ovarian reserve include AMH level, folliclestimulating hormone concentrations, inhibin-B level, and antral follicle count on ultrasound [7]. However, due to the development of genetic testing, several candidate genes for ovarian insufficiency are being investigated [85].…”

Section: Genetic Screening Of Candidate Markersmentioning

confidence: 99%

“…Chemotherapy could harm gonadal function in young cancer patients and cause loss of the ovarian reserve [6]. The molecular mechanism of chemotherapy-induced ovarian damage has been investigated to understand and prevent gonadotoxicity in cancer treatment [7]. However, the genetic aspects of chemotherapy-induced ovarian damage are still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation

Kim

Lee

Park

et al. 2021

Genes

Self Cite

View full text Add to dashboard Cite

Chemotherapy-induced ovarian damage and fertility preservation in young patients with cancer are emerging disciplines. The mechanism of treatment-related gonadal damage provides important information for targeting prevention methods. The genomic aspects of ovarian damage after chemotherapy are not fully understood. Several studies have demonstrated that gene alterations related to follicular apoptosis or accelerated follicle activation are related to ovarian insufficiency and susceptibility to ovarian damage following chemotherapy. This may accelerate follicular apoptosis and follicle reservoir utilization and damage the ovarian stroma via multiple molecular reactions after chemotherapy. This review highlights the importance of genomic considerations in chemotherapy-induced ovarian damage and multidisciplinary oncofertility strategies for providing high-quality care to young female cancer patients.

show abstract

Section: Mechanism Of Chemotherapy-induced Ovarian Damagementioning

confidence: 99%

Section: Mechanism Of Chemotherapy-induced Ovarian Damagementioning

confidence: 99%

Section: Genetic Screening Of Candidate Markersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation

Kim

Lee

Park

et al. 2021

Genes

Self Cite

View full text Add to dashboard Cite

show abstract

“…The activation of the primordial follicle is very complex [33]. Researchers have tried to cover the underlying mechanism that leads to massive or even total follicle depletion during continuous and prolonged chemotherapy [43]. From the dormant state, a primordial follicle activates when needing to take part in the growing pool.…”

Section: Ovarian Burnoutmentioning

confidence: 99%

A Warning Call for Fertility Preservation Methods for Women Undergoing Gonadotoxic Cancer Treatment

et al. 2021

View full text Add to dashboard Cite

Malignant hematological conditions have recognized an increased incidence and require aggressive treatments. Targeted chemotherapy, accompanied or not by radiotherapy, raises the chance of defeating the disease, yet cancer protocols often associate long-term gonadal consequences, for instance, diminished or damaged ovarian reserve. The negative effect is directly proportional to the types, doses, time of administration of chemotherapy, and irradiation. Additionally, follicle damage depends on characteristics of the disease and patient, such as age, concomitant diseases, previous gynecological conditions, and ovarian reserve. Patients should be adequately informed when proceeding to gonadotoxic therapies; hence, fertility preservation should be eventually regarded as a first-intention procedure. This procedure is most beneficial when performed before the onset of cancer treatment, with the recommendation for embryos or oocytes’ cryopreservation. If not feasible or acceptable, several options can be available during or after the cancer treatment. Although not approved by medical practice, promising results after in vitro studies increase the chances of future patients to protect their fertility. This review aims to emphasize the mechanism of action and impact of chemotherapy, especially the one proven to be gonadotoxic, upon ovarian reserve and future fertility. Reduced fertility or infertility, as long-term consequences of chemotherapy and, particularly, following bone marrow transplantation, is often associated with a negative impact of recovery, social and personal life, as well as highly decreased quality of life.

show abstract

Static magnetic field assisted thawing improves cryopreservation of mouse whole ovaries

Zhang,

Chi,

Cheng

et al. 2023

Bioengineering & Transla Med

View full text Add to dashboard Cite

Ovarian tissue cryopreservation is considered to be the only means to preserve fertility for prepubertal girls and women whose cancer treatment cannot be postponed. However, ovarian tissues are inevitably damaged by oxidative stress during cryopreservation, which threatens follicle survival and development, and thus affects female fertility. Therefore, reducing tissue oxidative stress injury is one of the major challenges to achieving efficient cryopreservation of ovarian tissues, especially for whole ovaries. Here, we proposed a new method to improve the antioxidant capacity of whole ovaries during cryopreservation, static magnetic field assisted thawing. The results demonstrated that the antioxidant capacity of the ovarian tissue was significantly improved by static magnetic field treatment. In addition, ovarian tissue allograft transplantation was carried out, which successfully achieved vascular regeneration and maintained follicular development. The findings of this study not only provide a new reference for the preservation of female fertility, but also is a major step forward in the cryopreservation of tissues and organs. It will have good application prospects in the field of assisted reproduction and cryo‐biomedicine.

show abstract

Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage

Cited by 51 publications

References 253 publications

Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation

Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation

A Warning Call for Fertility Preservation Methods for Women Undergoing Gonadotoxic Cancer Treatment

Static magnetic field assisted thawing improves cryopreservation of mouse whole ovaries

Contact Info

Product

Resources

About