Molecular Mechanism of Curcumin and Its Analogs as Multifunctional Compounds against Pancreatic Cancer

Huang, Qun; Zhang, Ya; Zheng, Yanlin; Yang, Hongjing; Yang, Yang; Mo, Ya; Li, Liuying; Zhang, Hong

doi:10.1080/01635581.2022.2071451

Cited by 7 publications

(5 citation statements)

References 96 publications

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“…Turmeric is obtained from plants of the genus Curcuma and its main components are essential oil, fat oil, and curcumin, with the most active component being curcumin (C 21 H 20 O 6 ), a β -diketone polyphenolic compound. Curcumin is used as a non-steroidal anti-inflammatory drug and has the effect of breaking blood, promoting Qi, and relieving pain through the meridional circulation ( Huang et al, 2022 ). The anti-pancreatic cancer mechanism of curcumin may include: ① Inhibiting cell migration ( Li, W., et al, 2019 ; Li W et al, 2018 ; Nagaraju et al, 2019 ); ② Downregulating the expression of Bcl-2 and upregulating the expression of BAX, decreasing the Bcl-2/BAX ratio, and thus inducing apoptosis ( Zhu and Bu, 2017 ); ③Inhibiting the epithelial-mesenchymal transformation of pancreatic cancer PANC-1 cells induced by TGF- β 1, thereby reducing the possibility of invasion and distant metastasis ( Wang, Q., et al, 2017 ; Cao et al, 2016b ; Li W, et al, 2020 ); ④ Counteracting angiogenesis through reducing the activity of COX-2, preventing the synthesis of PGE2 and thus inhibiting tumor formation ( Nagaraju et al, 2015 ); ⑤ Inhibiting pancreatic cancer stem cells ( Ning et al, 2016 ); ⑥ Inhibiting the phosphorylation of STAT3 in pancreatic cancer cell lines, thus blocking STAT3 activation, and promoting apoptosis by enhancing the cytotoxicity of natural killer (NK) cells ( Glienke et al, 2010 ; Fiala, 2015 ; Malhotra et al, 2022 ); ⑦ Inhibiting the growth of xenograft tumors and the biological activity of pancreatic cancer cells by regulating the miR-21–5p/SMAD7 axis ( Liu et al, 2012 ; Fang et al, 2022 ).…”

Section: Treatment With Chinese Herbsmentioning

confidence: 99%

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Zhang,

Xu,

et al. 2023

Front. Pharmacol.

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Pancreatic cancer is a common malignancy of the digestive system. With a high degree of malignancy and poor prognosis, it is called the “king of cancers.” Currently, Western medicine treats pancreatic cancer mainly by surgical resection, radiotherapy, and chemotherapy. However, the curative effect is not satisfactory. The application of Traditional Chinese Medicine (TCM) in the treatment of pancreatic cancer has many advantages and is becoming an important facet of comprehensive clinical treatment. In this paper, we review current therapeutic approaches for pancreatic cancer. We also review the protective effects shown by TCM in different models and discuss the potential molecular mechanisms of these.

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Section: Treatment With Chinese Herbsmentioning

confidence: 99%

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Zhang,

Xu,

et al. 2023

Front. Pharmacol.

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“…16 Curcumin, a phytochemical from Curcuma longa has been reported against breast, colorectal, pancreatic, lung, and head and neck cancer. [17][18][19][20][21]…”

Section: Natural Products and Cancermentioning

confidence: 99%

Therapeutic and Anticancer Properties of Nerium oleander– A Poison as Medicine

James,

Jayaprakash

2023

IJDDT

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Cancer is a heterogeneous disease and ranks among the most pressing health concerns faced by humans and requires a proactive treatment approach. Plants are a rich source of compounds and offer a promising avenue for cancer research. Chemotherapy has so far been effective, but it comes with some very unpleasant side effects. Nerium oleander, an evergreen plant cultivated throughout the world, has many metabolites, including cardiac glycosides, phenols, saponins and terpenoids. The plant and its derivatives have been an essential component of traditional medicine for treating several ailments from the beginning of time, notably cancer, diabetes mellitus, asthma, and cardiac disease. However, the scientific community has not gone much further into the information. This review aims to understand the therapeutic applications of N. oleander, focusing on cancer. The leaf extract, anvirzel and PBI-05204 has entered clinical trials and other derivates like oleandrin and breast in are still under in-vitro and in-vivo studies. In order to combat cancer, the plant operates on several cancer-related signaling pathways, including the Akt mTOR downstream pathway.

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“…Further this analogue could inhibit the inflammatory cytokines (IL-1β, IL-6, IL-8, and IL-15) secretion via the inhibition of JNK pathway ( Chen et al, 2022a ). The anti-pancreatic cancer effects and mechanisms of curcumin and its derivatives are described in detail ( Huang et al, 2022 ).…”

Section: Natural Products Undergoing Clinical Evaluation In Pancreati...mentioning

confidence: 99%

The therapeutic potential of natural products for treating pancreatic cancer

Wang

Zhang

et al. 2022

Front. Pharmacol.

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Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.

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Molecular Mechanism of Curcumin and Its Analogs as Multifunctional Compounds against Pancreatic Cancer

Cited by 7 publications

References 96 publications

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Advances in the treatment of pancreatic cancer with traditional Chinese medicine

Therapeutic and Anticancer Properties of Nerium oleander– A Poison as Medicine

The therapeutic potential of natural products for treating pancreatic cancer

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