Molecular mechanism of curcumin on periodontitis: A pharmacological network study

Guzmán-Flores, Juan Manuel; Arévalo-Caro, Catalina; Isiordia-Espinoza, Mario Alberto; Torre, Lorenzo Franco‐de la

doi:10.1016/j.job.2023.08.004

Cited by 2 publications

(3 citation statements)

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“…These two immune molecules have been associated with caries. CXCL8 has been reported to be overexpressed in carious lesions, and a genetic variant of IL1B has been associated with caries susceptibility, and both have been reported as therapeutic targets of curcumin in periodontitis [ 9 , 41 , 42 ]. Therefore, according to previous reports, the seven key proteins can be regulated by curcumin.…”

Section: Discussionmentioning

confidence: 99%

“…Curcuma longa L. has many active compounds, the most important of which is curcumin. Several studies have shown that curcumin benefits different diseases [ 8 , 9 , 10 ]. Some studies revealed that curcumin could potentially prevent and be essential in treating dental caries as a natural, accessible, safe, and inexpensive agent to increase oral and dental health [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

Guzmán-Flores,

Pérez-Reyes,

Vázquez-Jiménez

et al. 2024

Dentistry Journal

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Background: Dental caries is a dynamic, multifactorial disease that destroys teeth and can affect anyone’s quality of life because it can cause tooth loss and make chewing difficult. Dental caries involves various factors, such as Streptococcus mutans and host factors. Currently, adjuvant therapies, such as curcumin, have emerged, but how they work has not been adequately described. Therefore, this work aims to identify the molecular mechanism of curcumin in caries and Streptococcus mutans. Methods: We obtained differentially expressed genes from a GEO dataset, and curcumin targets were obtained from other databases. The common targets were analyzed according to gene ontology enrichment, key genes were obtained, and binding to curcumin was verified by molecular docking. Results: Our analysis showed that curcumin presents 134 therapeutic targets in caries. According to the gene ontology analysis, these targets are mainly involved in apoptosis and inflammation. There are seven key proteins involved in the action of curcumin on caries: MAPK1, BCL2, KRAS, CXCL8, TGFB1, MMP9, and IL1B, all of which spontaneously bind curcumin. In addition, curcumin affects metabolic pathways related to lipid, purine, and pyrimidine metabolism in Streptococcus mutans. Conclusions: Curcumin affects both host carious processes and Streptococcus mutans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

Guzmán-Flores,

Pérez-Reyes,

Vázquez-Jiménez

et al. 2024

Dentistry Journal

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“…Inflammatory cytokines, however, have been shown to upregulate expression of these molecules ( Kawasaki et al, 2015 ). Moreover, the inhibitory effects of Curcumin on proinflammatory cytokines such as IL-6, cell migration through chemokines receptors and LPS-induced COX-2 expression are major factors in the pathogenesis of periodontal disease ( Livada et al, 2017 ; Guzmán-Flores et al, 2023 ), and alveolar bone resorption might explain the beneficial effects of Curcumin as an adjunct to periodontal treatment ( Hong et al, 2004 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin gel on inflammatory and anti-inflammatory biomarkers in experimental induced periodontitis in rats: a biochemical and immunological study

Mohammad,

Ali,

Sha

et al. 2023

Front. Microbiol.

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This study aimed to determine the effect of local application of curcumin gels as adjunct to scaling and root planing (SRP) on the inflammatory biomarkers matrix metalloproteinase-8 (MMP-8), interleukin-6 (IL-6), C-reactive protein (CRP), and alkaline phosphatase (ALP), and the anti-inflammatory biomarker interleukin-10 (IL-10) in rats with experimentally induced periodontitis. Fifty-five adult Wistar rats with experimentally induced periodontitis were randomly divided into four groups: 15 rats received SRP + curcumin gel (CU), 15 rats received SRP + Tetracycline gel (Tet), 15 rats were treated with SRP alone, and 5 rats had experimental periodontitis without treatment (EP). Five systemically healthy rats without experimental periodontitis were used as the controls. Blood samples were collected by cardiac puncture from all groups after 2, 4, and 6 weeks of therapy. Biomarker levels determined by enzyme-linked immunosorbent assay (ELISA) and, ANOVA were used to compare the study groups. The results showed a significant increase in pro-inflammatory biomarkers and a significant decrease in anti-inflammatory biomarkers in the EP group compared with the control group (p < 0.05). The local application of curcumin or tetracycline gels resulted in a significant reduction in all inflammatory biomarkers at all periods of examination compared to the EP group. IL-10 levels gradually increased after 2 weeks, peaked at 4 weeks, and then decreased after 6 weeks, however, Tet showed statistically significant improvement compared to CU (p < 0.05). Adjunctive application of CU gel was as effective as Tet gel in the treatment of EP in rats by reducing inflammatory biomarkers and enhancing anti-inflammatory cytokines.

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Molecular mechanism of curcumin on periodontitis: A pharmacological network study

Cited by 2 publications

References 48 publications

A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans

Effect of Curcumin gel on inflammatory and anti-inflammatory biomarkers in experimental induced periodontitis in rats: a biochemical and immunological study

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