Molecular mechanism of mammary gland involution: An update

Jena, Manoj Kumar; Jaswal, Shalini; Kumar, Sanjay; Mohanty, Ashok Kumar

doi:10.1016/j.ydbio.2018.11.002

Cited by 76 publications

(67 citation statements)

References 148 publications

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“…Involution is characterized by the regression of the lactating epithelium through programmed cell death and remodeling of the mammary gland, which is induced upon weaning of the pups (Jena et al, 2019). Interestingly, withdrawal of LM from lactating organoids also induced a size regression and loss of the branched morphology with luminal architecture (Figures 2B-E).…”

Section: Lm Withdrawal Triggers Involution-like Phenotype In Lactatinmentioning

confidence: 98%

“…After weaning, when milk production is no longer required, milkproducing epithelial cells are removed, and mammary gland is remodeled into a prepregnancy state. This process is called involution, which includes programmed cell death of the epithelium, ECM remodeling, and redifferentiation of adipocytes (Hughes and Watson, 2012;Macias and Hinck, 2012;Zwick et al, 2018;Jena et al, 2019). By the end of involution, mammary gland is ready for a new cycle of pregnancy-associated growth, lactation, and subsequent involution, which can be repeated throughout the reproductive lifespan.…”

Section: Introductionmentioning

confidence: 99%

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Primary Mammary Organoid Model of Lactation and Involution

Sumbal

Chiche

Charifou

et al. 2020

Front. Cell Dev. Biol.

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Section: Lm Withdrawal Triggers Involution-like Phenotype In Lactatinmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Primary Mammary Organoid Model of Lactation and Involution

Sumbal

Chiche

Charifou

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

“…Involution is characterized by the regression of the lactating epithelium and remodeling of the mammary gland, which is induced upon the weaning of the pups (Jena et al, 2019). Interestingly, withdrawal of LM from lactating organoids also induced the size regression and loss of the branched morphology with luminal architecture (Fig.…”

Section: Lm Withdrawal Triggers Involution-like Phenotype In Lactatinmentioning

confidence: 95%

“…After weaning, when milk production is no longer required, milkproducing epithelial cells are removed, and mammary gland is remodeled into a prepregnancy state. This process is called involution, which includes programed cell death of the epithelium, extracellular matrix (ECM) remodeling and re-differentiation of adipocytes (Hughes and Watson, 2012;Macias and Hinck, 2012;Zwick et al, 2018;Jena et al, 2019). By the end of involution, mammary gland is ready for a new cycle of pregnancy-associated growth, lactation and subsequent involution, which can be repeated throughout the reproductive lifespan.…”

Section: Introductionmentioning

confidence: 99%

Primary mammary organoid model of lactation and involution

Sumbal

Chiche

Charifou

et al. 2019

Preprint

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Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.

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“…Durante o período seco (PS) das vacas leiteiras, a glândula mamária (GM) passa por alterações fisiológicas e histológicas que afetam a saúde do úbere e a produção de leite da próxima lactação (HURLEY et al, 1989;HENDERSON et al, 2016;JENA et al, 2019). Por este fato, a secagem é uma ótima oportunidade para tratar IIM existentes, embora também seja um período de alto risco ao desenvolvimento de novas infecções intramamárias (NIIM;…”

Section: Introductionunclassified

>b<Eficácia do selante interno de tetos na secagem de vacas leiteiras sobre a saúde do úbere>/b<

Freu¹

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Primeiramente agradeço a Deus, pela dádiva da vida e por me dar discernimento e força durante todas as etapas deste estudo. Obrigado por me permitir errar, aprender e crescer. Agradeço também pelas vacas, obras de sua criação e que se tornaram uma paixão pra mim e fruto de meu trabalho. À minha família, que apesar da distância, jamais me deixaram faltar amor, carinho, companheirismo e confiança. Vocês souberam entender minhas ausências, souberam compreender e me apoiar durante os momentos de dificuldade, mas também vibraram comigo todas as minhas conquistas. Obrigado mãe, pai e irmão por cada palavra de incentivo e apoio, amo vocês! À minha namorada Larissa, a joia que a vida me presenteou, a quem admiro e sou muito grato. Obrigado por suportar e ser paciente durante os momentos de angústia e tristeza. Tua companhia, teu abraço, teu amor e palavras de carinho amenizaram a dor e abrilhantaram meus dias. Ao meu orientador Prof. Marcos Veiga dos Santos, pela confiança, por todas as oportunidades e pela orientação. O senhor é um grande incentivador e responsável pelo meu crescimento pessoal e profissional. Sem dúvidas contribuíste muito para que mais um de meus êxitos (a finalização desta dissertação) fosse possível.

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Molecular mechanism of mammary gland involution: An update

Cited by 76 publications

References 148 publications

Primary Mammary Organoid Model of Lactation and Involution

Primary Mammary Organoid Model of Lactation and Involution

Primary mammary organoid model of lactation and involution

>b<Eficácia do selante interno de tetos na secagem de vacas leiteiras sobre a saúde do úbere>/b<

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