Molecular Mechanism of Microtubules Dynamics and its Precise Regulation Inside Cells

Abstract

Microtubules are tubulin polymers that use nucleoside triphosphate (GTP) hydrolysis for polymerization. Microtubules (MTs) are involved in diverse and dynamic cellular functions like cell shape maintenance, cell division, cell migration, and signalling. Microtubules display dynamic behaviour of Treadmilling and microtubule dynamics, these processes are precisely regulated by microtubule associated proteins. Inside the cells, soluble and polymeric fraction of tubulin is in equilibrium state that is regulated by microtubule polymerizing and depolymerizing proteins.