Molecular mechanism of non-coding RNA targeting zinc finger binding protein 1 and cervical cancer cells suppression

Cao, Xuexia; Su-fen, Zhao

doi:10.1016/j.jksus.2022.101870

Journal of King Saud University - Science

2022

DOI: 10.1016/j.jksus.2022.101870

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Molecular mechanism of non-coding RNA targeting zinc finger binding protein 1 and cervical cancer cells suppression

Xuexia Cao

Zhao Su-fen

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2023

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Serum sirtuin1: a potential blood biomarker for early diagnosis of Alzheimer’s disease

Wang,

Zhou,

Xiong

et al. 2023

Aging

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Background: Sirtuin 1, a nicotinamide adenine dinucleotide-dependent deacetylase that is highly expressed in the hippocampus and anterior cortex tissues related to Alzheimer’s Disease pathology, can cross the blood-brain barrier and is a promising biomarker. Methods: A 1:1:1 case-control study was conducted and serum fasting blood glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, SIRT1, IL-6, Aβ1-42, T-tau and P-tau-181 levels were evaluated in blood samples of 26 patients form the Alzheimer’s Disease group, 26 patients form the mild cognitive impairment group, and 26 individuals form the normal control group. Receiver operator characteristic curves were used to evaluate the diagnostic significance. Results: Serum SIRT1 level was significantly down-regulated in the mild cognitive impairment patients and Alzheimer’s Disease patients compared with that in the normal control group ( P <0.05). ROC curve analysis demonstrated that SIRT1 was a promising biomarker to distinguish Alzheimer’s Disease patients from the mild cognitive impairment patients and the normal control group. In addition, SIRT1 was estimated to perform well in the diagnosis of Alzheimer’s Disease ([AUC] = 0.742). Conclusions: In summary, the present study suggested that serum SIRT1 might be an early promising diagnostic biomarker for Alzheimer’s Disease.

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Serum sirtuin1: a potential blood biomarker for early diagnosis of Alzheimer’s disease

Wang,

Zhou,

Xiong

et al. 2023

Aging

View full text Add to dashboard Cite

show abstract

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Molecular mechanism of non-coding RNA targeting zinc finger binding protein 1 and cervical cancer cells suppression

Cited by 1 publication

References 23 publications

Serum sirtuin1: a potential blood biomarker for early diagnosis of Alzheimer’s disease

Serum sirtuin1: a potential blood biomarker for early diagnosis of Alzheimer’s disease

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