Molecular Mechanism of Tumorigenesis and Biomarkers of Opisthorchiasis-associated Cholangiocarcinoma

Abstract

Definitive relationship has been confirmed between Opisthorchis viverrini infection and tumorigenesis of cholangiocarcinoma (CCA), by epidemiological investigation and animal experiments. In the O. viverrini endemic area, opisthorchiasis-associated CCA has been becoming a serious public health problem. Understanding of the molecular mechanisms of tumorigenesis of the infection-induced CCA will be helpful to develop new biomarkers for diagnosis and therapy. This review addresses recent progresses in molecular mechanism and biomarker of opisthorchiasisassociated CCA.

Current State of Knowledge on Blood and Tissue-Based Biomarkers for Opisthorchis viverrini-induced Cholangiocarcinoma: A Review of Prognostic, Predictive, and Diagnostic Markers

“…Even though there are many examples of lab-based experiments and small-scale human trials showing the usefulness of new biomarkers in the field of Ov-CCA [ 24 - 26 ], finding biomarkers and figuring out how to use them in clinical settings remains a major challenge. Identifying biomarkers that differentiate disease phenotypes, such as symptomatic versus asymptomatic or uncomplicated versus severe forms, holds substantial promise for improving prognostication and providing precise guidance for clinical researchers, physicians, and surgeons.…”

“…Even though there are many examples of lab-based experiments and small-scale human trials showing the usefulness of new biomarkers in the field of Ov-CCA [24][25][26], finding biomarkers and figuring out how to use them DOI:10.31557/APJCP.2024. 25.1.25 Potential Biomarkers for Opisthorchis viverrini Induced Cholangiocarcinoma in clinical settings remains a major challenge.…”