Molecular Mechanism Underling the Chemopreventive Effect of Turmeric and Banana Peel Extracts On 7, 12- Dimethylbenzeneanthracene (DMBA) - Induced Mammary Carcinogenesis in Female Mice

Abstract

Evaluate the anticarcinogenic effect of turmeric and banana peel extracts versus vitamins supplementation on 7, 12dimethylbenzeneanthracene (DMBA)-induced breast cancer in female mice. Phytochemical composition of turmeric and banana peel extracts was estimated colorimetrically. Plasma vitamins C, E and β-carotene were determined by high-performance liquid chromatography (HPLC),.Agarose gel electrophoresis was used to analyze DNA from the tissues. Prostate specific antigen (PSA) determinded by ELISA was used as a tumor marker. Crude extract of banana peel and turmeric extract were evaluated versus vitamin C, E and A supplementation in reversing DMBA induced carcinogensis. DMBA-induced changes were reversed by turmeric extract and to a lesser extent by banana peel extract or vitamins supplementation as evidenced by improved oxidants-antioxidants imbalance, apoptotic DNA fragmentation and decreased PSA.