Molecular Mechanisms and Functions of lncRNAs in the Inflammatory Reaction of Diabetes Mellitus

Abstract

Diabetes is a chronic inflammatory state, and several studies have shown that the mechanisms of insulin resistance and abnormal islet β-cell function in diabetes are closely related to inflammatory reactions. Inflammation plays a critical role in diabetic complications. Long noncoding RNAs (lncRNAs), a new area of genomic research for gene regulation, have complex biological functions in various aspects of cellular biological activity. Recent studies have shown that lncRNAs are associated with the regulation of inflammatory responses in various ways, including at the epigenetic, transcriptional, and posttranscriptional levels. This paper presents a brief review of studies on the mechanisms of lncRNAs in diabetic inflammation. The purpose of this article is to determine the role of lncRNAs in the process of diabetic inflammation and to provide new strategies for the use of lncRNAs in the treatments for diabetic inflammation.

Bioinformatics Analysis of the Inflammation-Associated lncRNA-mRNA Coexpression Network in Type 2 Diabetes

“…lncRNAs are transcripts that are greater than 200 nucleotides in length [ 12 ]. By interacting with DNA, RNA, or proteins at the transcriptional, translational, and posttranslational levels, lncRNAs are involved in many cellular processes [ 4 , 13 ]. lncRNA microarrays quickly and efficiently screen for differential lncRNAs associated with diseases or specific phenotypes to provide a theoretical basis for the occurrence, development, and prevention of human diseases.…”

“…Diabetes is considered a chronic inflammatory disease, and diabetic inflammation occurs widely in the complications associated with diabetes [ 4 ]. Complications of diabetes are a major health and economic burden [ 5 ].…”

An overview of natural products that modulate the expression of non-coding RNAs involved in oxidative stress and inflammation-associated disorders

“…They are relatively low in cost, readily available, easy to apply, and of lesser side effects, ( Dutta et al, 2019 ). Although usage of natural products is limited by extinction and/or inaccessibility of some species from which they are derived, complex and time-consuming isolation process and high complexity and instability of compounds found in NP ( Enna et al, 2001 ; Huang and Hu, 2021 ), they are still advantageous in their relatively low costs, availability, easy application and of lesser side effects, ( Dutta et al, 2019 ). Natural products have the ability to penetrate just as easily and reach their targets within or on the cell.…”