2023
DOI: 10.20944/preprints202304.1238.v1
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Molecular Mechanisms and Risk Factors Related to Pathogenesis of Peyronie's Disease

Abstract: Peyronie's disease (PD) is a benign condition caused by plaque formation on the tunica albuginea of the penis. It is associated with penile pain, curvature, and shortening, and contributes to erectile dysfunction, which worsens patient quality of life. In recent years, understanding of the detailed mechanisms and risk factors involved in development of PD has been increasing. In this review, the pathological mechanisms and several closely related signaling pathways, including TGF-β, WNT/β-catenin, Hed… Show more

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