2022
DOI: 10.1002/ctm2.689
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Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single‐cell sequencing

Abstract: Background Immune cells play important roles in mediating immune response and host defense against invading pathogens. However, insights into the molecular mechanisms governing circulating immune cell diversity among multiple species are limited. Methods In this study, we compared the single‐cell transcriptomes of immune cells from 12 species. Distinct molecular profiles were characterized for different immune cell types, including T cells, B cells, natural killer cells, monocytes, and dendritic cells. Results… Show more

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Cited by 15 publications
(15 citation statements)
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“…We further identified T effector cells and terminally differentiated cytotoxic effectors. The transcriptomic gradient of T cell differentiation was found to fit the paradigm seen with other species (23). Additionally, we captured feline γδ T cells for the first time.…”
Section: Discussionmentioning
confidence: 68%
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“…We further identified T effector cells and terminally differentiated cytotoxic effectors. The transcriptomic gradient of T cell differentiation was found to fit the paradigm seen with other species (23). Additionally, we captured feline γδ T cells for the first time.…”
Section: Discussionmentioning
confidence: 68%
“…Additionally, single cell data facilitates the study of cross species variations in immune cell type and evolution of these cells (12). ScRNA-seq of feline circulating leukocytes have been previously performed demonstrating the presence of 5 major cell types (T cells, B cells, NK cells, monocytes, dendritic cells) in the context of other non-model species (23).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…We further explored the putative target cells of viruses capable of causing blood infections (Figure 3 , Table S4 ), based on 46 associated viral entry factors belonging to nine virus families ( Arenaviridae, Filoviridae, Flaviviridae, Hepadnaviridae, Herpesviridae, Picornaviridae, Reoviridae, Retroviridae and Togaviridae ) using the PBMC data sets of 27 species, which contained the self‐produced dataset of 16 species and the public dataset of 11 species (human, 36 monkey, 37 hamster, 38 cat, 38 dog, 38 mouse, 39 rabbit, 38 deer, 38 goat, 38 pigeon 38 and zebrafish 40 ) (Figure 3 ). The viruses investigated covered common blood‐borne viruses such as human immunodeficiency virus (HIV, Retroviridae ), hepatitis B virus (HBV, Hepadnaviridae ) and Hepacivirus C (HCV, Flaviviridae ), viruses that can cause haemorrhagic fever ( Arenaviridae , Filoviridae , Flaviviridae and Togaviridae ) and others that can cause hepatitis, such as hepatitis A virus ( Picornaviridae ) and hepatitis E virus ( Herpesviridae ).…”
Section: Resultsmentioning
confidence: 99%
“…In addition, the cellular atlas in multiple tissues or organs of other species has been accomplished by scRNA-seq in recent years, e.g. tissue cells from 11 non-model animals ( 14 ), circulating immune cells among 12 species ( 15 ), eight organs and tissues of mouse embryos at different stages ( 12 ), mice lung cells across aging stages ( 16 , 17 ), and pig cerebral cortex, hypothalamus ( 18 ), and lung ( 2 ). Single-cell transcriptomic data from pathologic tissues of patients and animal models of diseases is generated rapidly, e.g.…”
Section: Introductionmentioning
confidence: 99%