Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction

Kollár, K; Cook, Matthew; Atkinson, Kerry; Brooke, Gary

doi:10.1155/2009/904682

Cited by 65 publications

(53 citation statements)

References 84 publications

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“…68,69 Chemokines and chemoattractant signals also regulate the mobilization and homing of bone marrow-derived as well as circulating stem cell populations to the tissue repair sites, including MSCs and endothelial progenitor cells (EPCs). Under the guidance of chemokine signaling, MSCs can selectively migrate to injured sites, including skin wound healing, 63,70,71 bone fractures, 72,73 myocardial infarctions, 74,75 and ischemic cerebral injuries, 76 where they engraft and contribute to tissue recovery. 76 Interestingly, recent reports demonstrated that mechanical stretching can upregulate stromal cell-derived factor-1 alpha (SDF1a) and hypoxia-inducible factor-1 alpha in skin and recruit circulating MSCs and other stem cells through the SDF-1a/CXCR4 pathway.…”

Section: Chemokines In Fetal and Adult Wound Healingmentioning

confidence: 99%

Chemokine Involvement in Fetal and Adult Wound Healing

Balaji

Watson

Ranjan

et al. 2015

Advances in Wound Care

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Section: Chemokines In Fetal and Adult Wound Healingmentioning

confidence: 99%

Chemokine Involvement in Fetal and Adult Wound Healing

Balaji

Watson

Ranjan

et al. 2015

Advances in Wound Care

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“…tion, which was pronounced in L-MSCs compared with BMMSCs, is known to promote trans-endothelial migration and homing [54]. Also, L-MSCs expressed more PDGFRa, an important receptor for PDGF AA that regulates cell motility [55][56][57]. Similarly, directional migration as evidenced by chemo-attractant-driven responses to PDGF AA , PDGF BB , and FGF 2 in transwell experiments was also more pronounced in L-MSCs than BM-MSCs, consistent with differences in receptors (e.g., PDGFRa).…”

mentioning

confidence: 99%

Lung-Derived Mesenchymal Stromal Cell Post-Transplantation Survival, Persistence, Paracrine Expression, and Repair of Elastase-Injured Lung

Hoffman

Paxson

Mazan

et al. 2011

Stem Cells and Development

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While multipotent mesenchymal stromal cells have been recently isolated from adult lung (L-MSCs), there is very limited data on their biological properties and therapeutic potential in vivo. How L-MSCs compare with bone marrow-derived MSCs (BM-MSCs) is also unclear. In this study, we characterized L-MSC phenotype, clonogenicity, and differentiation potential, and compared L-MSCs to BM-MSCs in vivo survival, retention, paracrine gene expression, and repair or elastase injury after transplantation. L-MSCs were highly clonogenic, frequently expressed aldehyde dehydrogenase activity, and differentiated into osteocytes, chondrocytes, adipocytes, myofibroblasts, and smooth muscle cells. After intravenous injection (2 h), L-MSCs showed greater survival than BMMSCs; similarly, L-MSCs were significantly more resistant than BM-MSCs to anchorage independent culture (4 h) in vitro. Long after transplantation (4 or 32 days), a significantly higher number of CD45 neg L-MSCs were retained than BM-MSCs. By flow cytometry, L-MSCs expressed more intercellular adhesion molecule-1 (ICAM-1), platelet derived growth factor receptor alpha (PDGFRa), and integrin a2 than BM-MSCs; these proteins were found to modulate endothelial adherence, directional migration, and migration across Matrigel in L-MSCs. Further, L-MSCs with low ICAM-1 showed poorer lung retention and higher phagocytosis in vivo. Compared with BM-MSCs, L-MSCs expressed higher levels of several transcripts (e.g., Ccl2, Cxcl2, Cxcl10, IL-6, IL-11, Hgf, and Igf2) in vitro, although gene expression in vivo was increased by L-MSCs and BM-MSCs equivalently. Accordingly, both L-MSCs and BM-MSCs reduced elastase injury to the same extent. This study demonstrates that tissuespecific L-MSCs possess mechanisms that enhance their lung retention after intravenous transplantation, and produce substantial healing of elastase injury comparable to BM-MSCs.

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“…However, some phenotypical specificities, such as higher expression of CD44 by PL-MSC, compared with MSCs from other dental tissues, could be due to the inflammatory origin of these cells (14). We found that STRO-1, a marker for MSCs (15), showed a lower membrane expression.…”

Section: Discussionmentioning

confidence: 64%

Mesenchymal Stem Cells from Periapical Lesions Upregulate the Production of Immunoregulatory Cytokines by Inflammatory Cells in Culture / Mezenhimske matične ćelije iz periapeksnih lezija stimulišu produkciju imunoregulacijskih citokina od strane inflamacijskih ćelija u kulturi

Marković¹,

Tomić²,

Djokić³

et al. 2015

Acta Facultatis Medicae Naissensis

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The pathophysiology of periapical lesions (PLs) is under control of pro-inflammatory and anti-inflammatory (mainly immunoregulatory) cytokines. We have recently established mesenchymal stem cells (MSCs) from PLs and showed their suppressive effects on the production of proinflammatory cytokines from PLs inflammatory cells (ICs). In this work we studied the production of interleukin (IL)-10, IL-27 and transforming growth factor (TGF)-β, by PL-ICs in direct or indirect contacts with PL-MSCs. PL-ICs, which were isolated from four different asymptomatic PLs, predominantly composed of lymphocytes, followed by neutrophil granulocytes, macrophages and plasma cells. PLMSCs, expressing typical MSC markers, were co-cultivated with PL-ICs at 1:10 ratio, either in direct contact or in a transwell-system, for 24 hours. The levels of cytokines in cell-culture supernatants were tested by ELISA. The results showed that PL-MSCs up-regulated the production of all three immunoregulatory cytokines by PL-ICs. PL-MSCs stimulated the production of IL-10 and IL-27 via soluble factors, whereas the up-regulation of TGF-β required direct cell-to-cell contacts. In conclusion, our results showed for the first time the involvement of PL-MSCs in restriction of inflammation in PLs by up-regulation of immunoregulatory cytokines.

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Molecular Mechanisms Involved in Mesenchymal Stem Cell Migration to the Site of Acute Myocardial Infarction

Cited by 65 publications

References 84 publications

Chemokine Involvement in Fetal and Adult Wound Healing

Chemokine Involvement in Fetal and Adult Wound Healing

Lung-Derived Mesenchymal Stromal Cell Post-Transplantation Survival, Persistence, Paracrine Expression, and Repair of Elastase-Injured Lung

Mesenchymal Stem Cells from Periapical Lesions Upregulate the Production of Immunoregulatory Cytokines by Inflammatory Cells in Culture / Mezenhimske matične ćelije iz periapeksnih lezija stimulišu produkciju imunoregulacijskih citokina od strane inflamacijskih ćelija u kulturi

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