Molecular mechanisms linking calorie restriction and longevity

Merry, B.J.

doi:10.1016/s1357-2725(02)00038-9

Cited by 270 publications

(210 citation statements)

References 78 publications

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“…The difference in mitochondria localization has been associated with developmental competence of oocytes (Ferreira et al., 2009). The mitochondrial membrane potential must be maintained to support ATP synthesis; however, a high potential will favor the production of deleterious ROS (Merry, 2002). It is worth noting that mitochondrial function and redox state are important for proper assembly of meiotic structure during oocyte meiosis.…”

Section: Discussionmentioning

confidence: 99%

SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation

Zeng

Jiang²,

et al. 2018

Aging Cell

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SIRT4 modulates energy homeostasis in multiple cell types and tissues. However, its role in meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT4 are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reactive oxygen species (ROS) level, with the severely disrupted spindle/chromosome organization. Moreover, we find that phosphorylation of Ser293‐PDHE1α mediates the effects of SIRT4 overexpression on metabolic activity and meiotic events in oocytes by performing functional rescue experiments. By chance, we discover the SIRT4 upregulation in oocytes from aged mice; and importantly, the maternal age‐associated deficient phenotypes in oocytes can be partly rescued through the knockdown of SIRT4. These findings reveal the critical role for SIRT4 in the control of energy metabolism and meiotic apparatus during oocyte maturation and indicate that SIRT4 is an essential factor determining oocyte quality.

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Section: Discussionmentioning

confidence: 99%

SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation

Zeng

Jiang²,

et al. 2018

Aging Cell

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“…It has been known for many decades that restricting daily calorie intake in rodents and some other animals increases longevity substantially [85,86]. It is speculated that this may be because in times of famine reproductive activity is reduced, since any offspring would be unlikely to survive.…”

Section: Environmental Factors and Brain Ageingmentioning

confidence: 99%

Ageing and the brain

2007

The Journal of Pathology

177

111

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In this review, the evidence for changes in the human brain with ageing at both the macroscopic and microscopic levels is summarized. Loss of neurons is now recognized to be more modest than initial studies suggested and only affects some neuron populations. Accompanying loss of neurons is some reduction in the size of remaining neurons. This reflects a reduced size of dendritic and axonal arborizations. Some of the likely causes of these changes, including free radical damage resulting from a high rate of oxidative metabolism in neurons, glycation and dysregulation of intracellular calcium homeostasis, are discussed. The roles of genes and environmental factors in causing and responding to ageing changes are explored.

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“…This treatment is the most common manipulation in the study of aging and was first described for rats in 1935 (McCay et al 1935). The degree of life span extension is linearly related to the amount of CR in both rats (Merry 2002) and mice (Weindruch et al 1986), but the precise mechanism by which CR extends longevity is not known (Masoro 2002). A common finding is that lipid peroxidation is reduced during CR (Habib et al 1990;Matsuo et al 1993).…”

Section: Longevity Variation Within Speciesmentioning

confidence: 99%

Explaining longevity of different animals: is membrane fatty acid composition the missing link?

Hulbert

2008

AGE

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Saturated and monounsaturated fatty acids are very resistant to peroxidative damage, while the more polyunsaturated a fatty acid, the more susceptible it is to peroxidation. Furthermore, the products of lipid peroxidation can oxidatively damage other important molecules. Membrane fatty acid composition is correlated with the maximum lifespans of mammals and birds. Exceptionally long-living mammal species and birds have a more peroxidation-resistant membrane composition compared to shorter-living similar-sized mammals. Within species, there are also situations in which extended longevity is associated with peroxidation-resistant membrane composition. For example, caloric restriction is associated more peroxidation-resistant membrane composition; long-living queens have more peroxidation-resistant membranes than shorter-living worker honeybees. In humans, the offspring of nonagenarians have peroxidation-resistant erythrocyte membrane composition compared to controls. Membrane fatty acid composition is a little appreciated but important correlate of the rate of aging of animals and the determination of their longevity.

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Molecular mechanisms linking calorie restriction and longevity

Cited by 270 publications

References 78 publications

SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation

SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation

Ageing and the brain

Explaining longevity of different animals: is membrane fatty acid composition the missing link?

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