Molecular mechanisms of anti-angiogenic effect of curcumin

Gururaj, Anupama E.; Belakavadi, Madesh; Venkatesh, Deepak; Marmé, Dieter; Salimath, Bharathi P.

doi:10.1016/s0006-291x(02)02306-9

Cited by 224 publications

(134 citation statements)

References 41 publications

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“…Previous studies indicated that it efficiently induces antiproliferation and cell death in a variety of tumor cells (27,28) and blocks angiogenic phenotypes in tumor and endothelial cells (16,29). However, the molecular basis for the anti-angiogenic activity of curcumin and its target molecules has not yet been elucidated.…”

Section: Discussionmentioning

confidence: 99%

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Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1

Bae

Kim²,

Jeong³

et al. 2006

Oncol Rep

106

103

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Abstract. Hypoxia-inducible factor-1 (HIF-1) has a central role in cellular responses to hypoxia, including the transcriptional activation of a number of genes involved in angiogenesis in tumors. We found that curcumin, a natural, biologically active compound isolated from the commonly used spice turmeric, significantly decreases hypoxia-induced HIF-1· protein levels in HepG2 hepatocellular carcinoma cells. Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor. Curcumin also blocked hypoxia-stimulated angiogenesis in vitro and down-regulated HIF-1· and VEGF expression in vascular endothelial cells. These findings suggest that curcumin may play pivotal roles in tumor suppression via the inhibition of HIF-1·-mediated angiogenesis.

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Section: Discussionmentioning

confidence: 99%

“…Recently, curcumin was shown to inhibit vascular endothelial cell proliferation in vitro and capillary tube formation in vivo (16)(17)(18)(19). These studies demonstrated that the potent chemopreventive activity of curcumin may, in part, be derived from the direct inhibition of angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1

Bae

Kim²,

Jeong³

et al. 2006

Oncol Rep

106

103

View full text Add to dashboard Cite

show abstract

“…With the discovery of the role of angiogenesis in tumor growth and progression, considerable efforts have been directed towards antiangiogenic therapy as a new modality to treat human cancers. In recent years, attention has been given to identifying non-toxic, endothelial cell specific, diet-derived compounds as antiangiogenic agents for cancer therapy, in an effort to reduce the toxic side effects [3][4][5][6].…”

mentioning

confidence: 99%

Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and downregulation of VEGF

Belakavadi

Prabhakar

Salimath

2005

Biochemical and Biophysical Research Communications

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“…It has been reported that curcumin had antiangiogenic effect (Gururaj et al, 2002). In this research, we further investigated combination therapy reduced relative cell viability of MS-1 and LL/2 comparing with single curcumin or hyperthermia group (DMEM as control).…”

Section: Inhibition Of Cell Proliferation Of Ms-1 and Ll/2 In Vitromentioning

confidence: 97%

Enhanced Antitumor Effect of Curcumin Liposomes with Local Hyperthermia in the LL/2 Model

Tang

Shi²,

Wan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Curcumin previously was proven to inhibit angiogenesis and display potent antitumor activity in vivo and in vitro. In the present study, we investigated whether a combination curcumin with hyperthermia would have a synergistic antitumor effect in the LL/2 model. The results indicated that combination therapy significantly inhibited cell proliferation of MS-1 and LL/2 in vitro. LL/2 experiment model also demonstrated that the combination therapy inhibited tumor growth and prolonged the life span in vivo. Furthermore, combination therapy reduced angiogenesis and increased tumor apoptosis. Our findings suggest that the combination therapy exerted synergistic antitumor effects, providing a new perspective fpr clinical tumor therapy.

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Molecular mechanisms of anti-angiogenic effect of curcumin

Cited by 224 publications

References 41 publications

Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1

Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1

Butyrate-induced proapoptotic and antiangiogenic pathways in EAT cells require activation of CAD and downregulation of VEGF

Enhanced Antitumor Effect of Curcumin Liposomes with Local Hyperthermia in the LL/2 Model

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