Molecular mechanisms of anticancer activities of polyphyllin VII

Abstract

Cancer is the leading cause of mortality in the world. The major therapies for cancer treatment are chemotherapy, surgery, and radiation therapy. All these therapies expensive, toxic and show resistance. The plant-derived compounds are considered safe, cost-effective and target cancer through different pathways. In these pathways include oxidative stress, mitochondrial dependent and independent, STAT3, NF-kB, MAPKs, cell cycle, and autophagy pathways. One of the new plants derived compounds is Polyphyllin VII (PPVII), which target cancer through different molecular mechanisms. In literature, there is a review gap of studies on PPVII; therefore in the current review, we summarized the available studies on PPVII to provide a base for future research.

Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptor

“…Zhou et al, 2021). Several active compounds of CL such as polyphyllin D, polyphyllin A, polyphyllin I, polyphyllin II, polyphyllin VI (PPVI), and polyphyllin VII were identified (Wang Q. et al, 2018;Pang et al, 2020;Teng et al, 2020;Ahmad et al, 2021;Kwon et al, 2021). Bioactive chemicals from CL for the treatment of inflammatory pain and the underlying mechanisms were not fully elucidated.…”

“…Steroidal saponins, flavonoids, sugars, volatile oils, amino acids, trace minerals, etc., are among CL’s active constituents, mediating anti-tumor ( Tian et al, 2020 ), anti-infection ( Qiumin et al, 2017 ), organ-protecting ( Man et al, 2014 ), and anti-inflammatory effects ( Yan et al, 2021 ; Zhou et al, 2021 ). Several active compounds of CL such as polyphyllin D, polyphyllin A, polyphyllin I, polyphyllin II, polyphyllin VI (PPVI), and polyphyllin VII were identified ( Wang Q. et al, 2018 ; Pang et al, 2020 ; Teng et al, 2020 ; Ahmad et al, 2021 ; Kwon et al, 2021 ). Bioactive chemicals from CL for the treatment of inflammatory pain and the underlying mechanisms were not fully elucidated.…”

Acute generation of reactive oxygen species that induced by doxycycline pretreatment results in rapid cell death in polyphyllin G‐treated osteosarcoma cell lines

“…1,2 Polyphyllin G, one of major bioactive components isolated from rhizome of Paris polyphylla, has been found to exhibit strong anticancer effects in several cancer cells. 3 Polyphyllin G promotes apoptosis in HepG2 liver cancer cells via MAPK pathways and reactive oxygen species (ROS) generation. 4 Polyphyllin G increases ROS production and suppresses cell viability in ovarian cancer cell lines.…”

“…The rhizome of Paris polyphylla , a traditional Chinese medicine, has been reported to have multiple pharmacological activities including haemostatic, anti‐inflammatory, and anticancer effect 1,2 . Polyphyllin G, one of major bioactive components isolated from rhizome of Paris polyphylla , has been found to exhibit strong anticancer effects in several cancer cells 3 . Polyphyllin G promotes apoptosis in HepG2 liver cancer cells via MAPK pathways and reactive oxygen species (ROS) generation 4 .…”

A simple and sensitive LC–MS/MS method for the determination of polyphyllin VII in rat plasma and its application to pharmacokinetic study

“…Saponins extracted from this herb have been demonstrated to be the bioactive compounds responsible for its anticancer activities (Zhou et al, 2021). Polyphyllin VII, one of the most abundant saponins from P. polyphylla , has been proved to exert anticancer activities in a wide variety of human cancer cell lines (Ahmad et al, 2021). It exerts anticancer activities by the suppression of proliferation, cell cycle arrest, and modulation of drugs (He et al, 2016; Lin et al, 2015; Zhang, Jia, Bao, et al, 2016; Zhang, Jia, Wang, et al, 2016).…”