Molecular Mechanisms of Atrial Fibrillation

Wagoner, David R. Van; Nerbonne, Jeanne M.

doi:10.1016/b978-012656975-9/50063-8

Cited by 3 publications

(2 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For readers interested in aspects of I to not covered in this review the following sources may be of value: cell biology of I to , Birnbaum et al (2004); pathology, Chien (1999), Oudit et al (2001), Nerbonne (2004) and Zicha et al (2004); I to expression gradients in other regions of the heart (e.g. apical–basal gradients), Brahmajothi et al (1999), de Bakker & Opthof (2002) and Brunet et al (2004); and the role of I to phenotypes in supraventricular disturbances, Chien (1999), Van Wagoner & Nerbonne (2001) and Gussack & Antzelevitch (2003).…”

mentioning

confidence: 99%

Transient outward potassium current, ‘I_to’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

Patel

Campbell

2005

The Journal of Physiology

178

192

View full text Add to dashboard Cite

At least two functionally distinct transient outward K + current (I to ) phenotypes can exist across the free wall of the left ventricle (LV). Based upon their voltage-dependent kinetics of recovery from inactivation, these two phenotypes are designated 'I to,fast ' (recovery time constants on the order of tens of milliseconds) and 'I to,slow ' (recovery time constants on the order of thousands of milliseconds). Depending upon species, either I to,fast , I to,slow or both current phenotypes may be expressed in the LV free wall. The expression gradients of these two I to phenotypes across the LV free wall are typically heterogeneous and, depending upon species, may consist of functional phenotypic gradients of both I to,fast and I to,slow and/or density gradients of either phenotype. We review the present evidence (molecular, biophysical, electrophysiological and pharmacological) for Kv4.2/4.3 α subunits underlying LV I to,fast and Kv1.4 α subunits underlying LV I to,slow and speculate upon the potential roles of each of these currents in determining frequency-dependent action potential characteristics of LV subepicardial versus subendocardial myocytes in different species. We also review the possible functional implications of (i) ancillary subunits that regulate Kv1.4 and Kv4.2/4.3 (Kvβ subunits, DPPs), (ii) KChIP2 isoforms, (iii) spider toxin-mediated block of Kv4.2/4.3 (Heteropoda toxins, phrixotoxins), and (iv) potential mechanisms of modulation of I to,fast and I to,slow by cellular redox state, [Ca 2+ ] i and kinase-mediated phosphorylation. I to phenotypic activation and state-dependent gating models and molecular structure-function relationships are also discussed.

show abstract

mentioning

confidence: 99%

Transient outward potassium current, ‘I_to’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

Patel

Campbell

2005

The Journal of Physiology

178

192

View full text Add to dashboard Cite

show abstract

“…Atrial fibrillation (AF) is a cardiac arrhythmia prevalent in 0.4% of the overall population and responsible for a 1.5-1.9 fold increase of mortality in cardiac patients [1]. The search for AF precursors and preventive therapies remains one of the most challenging interdisciplinary problems.…”

Section: Introductionmentioning

confidence: 99%

Wave propagation in the atrial myocardium: dispersion properties in the normal state and before fibrillation

Anosov

Berdyshev

Khassanov

et al. 2002

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

Gap Junctions, Cardiac Excitability and Clinical Arrhythmias

Arnsdorf

Lee

2002

Heart Cell Coupling and Impulse Propagation in Health and Disease

View full text Add to dashboard Cite

Molecular Mechanisms of Atrial Fibrillation

Cited by 3 publications

References 87 publications

Transient outward potassium current, ‘I_to’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

Transient outward potassium current, ‘I_to’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

Wave propagation in the atrial myocardium: dispersion properties in the normal state and before fibrillation

Gap Junctions, Cardiac Excitability and Clinical Arrhythmias

Contact Info

Product

Resources

About

Molecular Mechanisms of Atrial Fibrillation

Cited by 3 publications

References 87 publications

Transient outward potassium current, ‘Ito’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

Transient outward potassium current, ‘Ito’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

Wave propagation in the atrial myocardium: dispersion properties in the normal state and before fibrillation

Gap Junctions, Cardiac Excitability and Clinical Arrhythmias

Contact Info

Product

Resources

About

Transient outward potassium current, ‘I_to’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

Transient outward potassium current, ‘I_to’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms