Molecular mechanisms of cognitive impairment associated with stroke

Kaur, Mandeep; Sharma, Saurabh

doi:10.1007/s11011-022-00901-0

Cited by 14 publications

(7 citation statements)

References 69 publications

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“…Control of cognitive function arises from a variety of sources at the molecular, cellular, and histological levels within the brain. This is driven by various mechanisms including phosphorylation imbalance, redox states, and neurotransmitter release/tone (Cui et al, 2008;Giralt et al, 2012;Yabuki et al, 2014;Kaur and Sharma, 2022). Cognitive dysfunction (used interchangeably with the terms cognitive deficit or cognitive impairment) encompasses impacts on cognitive processes associated with underlying conditions such as psychiatric disorders, neurodevelopmental disorders, neurodegenerative diseases, and aging.…”

Section: Cognitive Disorders and Dysfunctionmentioning

confidence: 99%

“…Cognitive dysfunction (used interchangeably with the terms cognitive deficit or cognitive impairment) encompasses impacts on cognitive processes associated with underlying conditions such as psychiatric disorders, neurodevelopmental disorders, neurodegenerative diseases, and aging. These conditions and their effects on cognition have been reviewed on numerous occasions (Organization and Levy, 1994;Gräff and Mansuy, 2009;Giralt et al, 2012;Millan et al, 2012;Yabuki et al, 2014;Kim et al, 2015;Kaur and Sharma, 2022;Dhakal and Bobrin, 2023;Hoglund et al, 2023).…”

Section: Cognitive Disorders and Dysfunctionmentioning

confidence: 99%

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Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

Parent,

Niswender

2024

Mol Pharmacol

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ADHD-attention deficit hyperactivity disorder ASD-autism spectrum disorder CNS-central nervous system CRD-cysteine-rich domain CREB-cAMP response element binding protein CTD-C-terminal domain ELFN1/2-extracellular leucine-rich repeat and fibronectin type III domain-containing 1/2 GAD-glutamic acid decarboxylase GIRK-G protein-coupled inwardly rectifying potassium channel GPCR-G protein-coupled receptor GRK-G protein-coupled receptor kinase GWAS-genome-wide association study ICD-international classification of disease L-AP4-L-2-amino-4-phosphonobutyric acid LTP-long term potentiation MAPK-mitogen-activated protein kinase MECP2-methyl CpG-binding protein 2

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Section: Cognitive Disorders and Dysfunctionmentioning

confidence: 99%

Section: Cognitive Disorders and Dysfunctionmentioning

confidence: 99%

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

Parent,

Niswender

2024

Mol Pharmacol

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“…Generally speaking, the causes of ischemic stroke could be divided into two categories. 1) Thrombosis formed in the arteries supplying the brain tissue; 2) Blood clots formed in the peripheral vessels were transferred to the cerebral vessels through the blood flow, resulting in embolism. , Since then, the blood supply to the brain had been reduced or interrupted, resulting in an insufficient supply of oxygen, glucose, and other essential nutrients to the brain, resulting in damage to brain cells and loss of function. , Damaged cells released a variety of molecular substances, such as cytokines, chemokines, injury-related factors, pro-inflammatory factors, etc., which promoted the polarization of activated microglia, resulting in further damage. , In addition, oxidative stress, glutamate excitability, nitrite stress, and cell edema also played an important role in aggravating tissue injury . After the duration of ischemia was too long, due to the role of anaerobic glycolysis, the formation and accumulation of local lactic acid led to edema and neuronal tissue damage .…”

Section: Strokementioning

confidence: 99%

Application of Nanotechnology-Based Products in Stroke

Cai

Sun

Chen

et al. 2023

ACS Chem. Neurosci.

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Stroke is a disease with high disability and high mortality in the world. Due to the existence of the blood-brain barrier (BBB), complex brain structure, and numerous neural signal pathways, the treatment methods are limited, so new drugs and new treatments need to be developed urgently. Thankfully, the advent of nanotechnology offered a new opportunity for biomedical development because of the unique properties of nanoparticles that give them the ability to traverse the BBB and accumulate in relevant regions of the brain. More importantly, nanoparticles could be modified on the surface to meet a variety of specific properties that people need. Some could be used for effective drug delivery, including tissue plasminogen activator (tPA), neuroprotective agents, genes, and cytokines; some nanoparticles were used as contrast agents and biosensors in medical imaging for further diagnosis of stroke; some were used to track target cells for prognosis of stroke; and some were used to detect pathological markers of stroke that appear at different stages. This Review looks at the application and research progress of nanoparticles in the diagnosis and treatment of stroke, hoping to bring some help to researchers.

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“…Whereas, it can be said that the possibility of cardiovascular disease in stroke patients is very high. It has been reported that stroke most often occurs within 2 weeks after acute myocardial infarction [17][18][19]. So, it needs to identify interventions by considering heart diseases in stroke care.…”

Section: Nursing Interventions For Stroke Patientsmentioning

confidence: 99%

Identifying nursing interventions captured in patients with stroke by Korean nursing students: Nursing interventions classification study

Park

2023

J Korean Gerontol Nurs

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Purpose: This study aimed to identify nursing interventions captured in patients with stroke by Korean nursing students for the categorization of nursing care tailored to the characteristics of stroke patients.Methods: To identify nursing interventions, a descriptive data analysis was conducted using case scenarios written by nursing students during clinical practice in rehabilitation care settings. The case scenarios were analyzed using the standard terminology classification system, nursing interventions classification (NIC), to identify and categorize interventions for patients with stroke.Results: As the result of analysis, we identified 10 most frequent NIC interventions. The most frequent NIC intervention was vital signs monitoring (N=244, 8.6%). The 89 nursing interventions were classified into 7 domains and 24 classes of the NIC system.Conclusion: The results of this study can be used as a basis for a list of nursing interventions tailored to the characteristics of patients with stroke and furthermore calculating nursing fees through the analysis of nursing interventions for these patients.

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Molecular mechanisms of cognitive impairment associated with stroke

Cited by 14 publications

References 69 publications

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

Application of Nanotechnology-Based Products in Stroke

Identifying nursing interventions captured in patients with stroke by Korean nursing students: Nursing interventions classification study

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