Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis

Grzanka, Alicja; Misiołek, Maciej; Golusiński, Wojciech; Jarząb, Jerzy

doi:10.1007/s00405-010-1330-z

Cited by 41 publications

(37 citation statements)

References 42 publications

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“…Previous studies have proven that topical steroids are effective for both CRSwNP and CRSsNP (evidence level I). The clinical efficacy of corticosteroids may depend in part on their ability to reduce the secretion of chemotactic cytokines from nasal mucosa and polyp epithelial cells …”

mentioning

confidence: 99%

Lack of additional effects of long‐term, low‐dose clarithromycin combined treatment compared with topical steroids alone for chronic rhinosinusitis in China: a randomized, controlled trial

Chen

Lai

Luo

et al. 2017

Int Forum Allergy Rhinol

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mentioning

confidence: 99%

Lack of additional effects of long‐term, low‐dose clarithromycin combined treatment compared with topical steroids alone for chronic rhinosinusitis in China: a randomized, controlled trial

Chen

Lai

Luo

et al. 2017

Int Forum Allergy Rhinol

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“…Both topical and systemic glucocorticoids may affect the eosinophil function by both directly reducing eosinophil viability and function or indirectly reducing the secretion of chemotactic cytokines by nasal mucosa and polyp epithelial cells. [12] Systemic steroids are reserved for advanced or refractory cases particularly when allergy is present and it results in relatively rapid short-term dramatic improvement, nasal symptoms and endoscopic findings (medical polypectomy). Simple saline nasal douching to help cleanse the nose prior to topical medications is beneficial as it improves nasal mucociliary clearance.…”

Section: Medicalmentioning

confidence: 99%

An Overview of Sinonasal Polyposis: A Prospective Study

Samantaray¹,

Pradhan²,

Biswal³

2016

jebmh

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INTRODUCTION Sinonasal polyposis, one of the most common inflammatory mass lesions of the nose affecting up to 40% of the population. They present with nasal obstruction, anosmia, rhinorrhoea, post-nasal drip, and less commonly headache. Their aetiology remains unclear, but they are known to have associations with allergy, asthma, infection, fungus, cystic fibrosis, and aspirin sensitivity. Strong genetic factors are implicated in the pathogenesis of SNP, but genetic and molecular alterations required for its development and progression are still unclear. Management of SNP involves a combination of conservative treatment and surgical treatment. There is good evidence for the use of corticosteroids (systematic and topical), both as primary treatment and as postoperative prophylaxis against recurrence, but the prolonged course of the disease and adverse effect of systematic steroid limits their use. Surgical treatment has been refined significantly over the past 20 years with the advent of endoscopic sinus surgery and, in general, is reserved for cases refractory to medical treatment. Recurrence of the polyposis is common with severe disease recurring in up to 10% of patients. Over the last two decades, increasing insights in the pathophysiology of nasal polyposis opens prospective for new pharmacological treatment options, with eosinophilic inflammation, IgE, fungi and staphylococcus aureus as potential targets. A better understanding of the pathophysiology underlying the persistent inflammatory state in SNP is necessary to ultimately develop novel pharmacotherapeutic approaches. Here, we present the newer treatment options available for better control and possibly cure of the disease.

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“…The mechanisms of action of corticosteroids in CRSwNP have been previously reviewed in the literature [32,33]. Corticosteroid's mechanisms involve corticosteroid receptors, which have been described to be present in all the nasal cell types with greatest numbers in epithelial cells, submucosal glands and leukocytes [34].…”

Section: Corticosteroid Efficacy In Chronic Rhinosinusitis With Nasalmentioning

confidence: 99%

Mucin Expression and Corticosteroid Efficacy in Chronic Rhinosinusitis with Nasal Polyps

Peiró¹,

Milara²,

Armengot³

et al. 2013

J Steroids Horm Sci

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is an upper airway respiratory disease of the sinuses which may develop resistance to corticosteroid efficacy. Corticosteroids are the main therapy of this disease and as part of their anti-inflammatory activity they are known to exert an effect in mucin expression. This review aims to describe the current state-of-the-art knowledge regarding mucin expression in CRSwNP and its possible relation with corticosteroid efficacy, by highlighting the differential expression of membranetethered versus secreted mucins in different subsets of CRSwNP with an emphasis in corticosteroid non-responder patients. In addition, this review aims to suggest potential interactions between mucins and corticosteroids that could be addressed in future research to ascertain the role of mucins in the corticosteroid resistant mechanisms of this disease. In this sense, among the different mucins, we will highlight the membrane-tethered MUC1 and its potential role in corticosteroid-resistant CRSwNP, as it is currently considered an especially relevant mucin due to its anti-inflammatory properties.

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Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis

Cited by 41 publications

References 42 publications

Lack of additional effects of long‐term, low‐dose clarithromycin combined treatment compared with topical steroids alone for chronic rhinosinusitis in China: a randomized, controlled trial

Lack of additional effects of long‐term, low‐dose clarithromycin combined treatment compared with topical steroids alone for chronic rhinosinusitis in China: a randomized, controlled trial

An Overview of Sinonasal Polyposis: A Prospective Study

Mucin Expression and Corticosteroid Efficacy in Chronic Rhinosinusitis with Nasal Polyps

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