Molecular mechanisms of hypothalamic-pituitary-ovarian/thyroid axis regulating age at first egg in geese

He, Zhiyu; Ouyang, Qingyuan; Chen, Qingliang; Song, Yang; Hu, Jiwei; Hu, Shenqiang; He, Hua; Li, Liang; Liu, Hehe; Wang, Jiwen

doi:10.1016/j.psj.2024.103478

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…TGIF1 is a member of the TALE homeodomain protein family, involved in various physiological processes, including lipid and carbohydrate metabolism and the inhibition of androgen receptor activity [ 44 ]. ERBB4 participates in modulating the MAPK signaling pathway, influencing the egg-laying behavior of poultry [ 45 ]. Chen et al [ 46 ] reported that the TGF-beta signaling pathway is essential for ovarian development.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic Identification, Genetic Characterization, and Selective Signal Detection of Huitang Duck

Ma,

Lin,

Yan

et al. 2024

Animals

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The Huitang duck (HT), a long-domesticated elite local breed from Hunan Province, China, with excellent meat quality, has not had its population genetic structure and genomic selective sweeps extensively studied to date. This study measured the phenotypic characteristics of HT and conducted comparative analysis between HT and 16 different duck breeds, including wild, indigenous, and meat breeds, to characterize its population structure and genetic potential. The results revealed that HT is a dual-purpose indigenous breed with a genetic background closely related to the Youxian sheldrake and Linwu ducks. In the selective sweep analysis between HT and Linwu ducks, genes such as PLCG2, FN1, and IGF2BP2, which are associated with muscle growth and development, were identified near the 27 selection signals. The comparison between HT and Jinding ducks revealed 68 selective signals that contained important genes associated with ovarian development (GRIK4, MAP3K8, and TGIF1) and egg-laying behaviors (ERBB4). Selective sweep analysis between HT and Youxian sheldrake ducks found 93 selective regions covering genes related to both meat (IGF1R and IGFBP5) and egg-production (FOXO3 and ITPR1) traits. Our study may provide novel knowledge for exploring the population structure and genetic potential of HT, offering a theoretical basis for its breeding strategies in the future.

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Section: Discussionmentioning

confidence: 99%

Phenotypic Identification, Genetic Characterization, and Selective Signal Detection of Huitang Duck

Ma,

Lin,

Yan

et al. 2024

Animals

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Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through the Vegfa‐Ephb2 Pair

Mu,

Li,

Yang

et al. 2024

Advanced Science

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Ovarian dysfunction is a major factor leading to female infertility. Understanding how to improve or reshape ovarian function has become an important entry point for preventing and treating female infertility caused by ovarian dysfunction. Here, plant‐derived compounds are screened for in vitro activity upon ovarian organoids derived from feeder‐free female germline stem cells. Tetrahydroxy stilbene glucoside (TSG) is found to promote the development of ovarian organoids. Single nucleus transcriptome sequencing and spatial transcriptome sequencing are used to establish a comprehensive spatiotemporal map to elucidate the role of TSG in ovarian organoid development, encompassing cell types and subtypes, transcription factors, pseudo‐time sequence, and cell communication dynamics. This analysis indicates that TSG promotes ovarian organoid development through the vascular endothelial growth factor A‐Eph receptor B2 ligand‐receptor pair between granulosa cells and oocytes. This study has enhanced the understanding of the mechanisms of ovarian organoid development, establishes a technical platform for screening compounds for treating infertility and related diseases, and lays a foundation for clinically applying plant‐derived compounds.

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Ovarian transcriptome profile from egg-laying period to incubation period of Changshun green-shell laying hens

Chen,

Wen,

2024

Preprint

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Background: Changshun green-shell laying hen with strong broodiness is a Chinese indigenous chicken breed. Little is known about the mechanisms responsible for ovary development of Changshun green-shell laying hens from egg-laying period (LP) to incubation period (BP). Here, RNA sequencing (RNA-seq) of ovaries from Changshun hens in LP and BP was performed to identify candidate genes and pathways associated with broodiness. Results: We identified 1650 differently expressed genes (DEGs), including 429 up-regulated and 1221 down-regulated DEGs, in chicken ovaries between LP and BP groups. GO and KEGG analysis further revealed that these DEGs were mainly involved in the pathways related to follicle development in chicken ovaries, including focal adhesion, MAPK signaling pathway, and FoxO signaling pathway, and vascular smooth muscle contraction, ECM-receptor interaction, and GnRH signaling pathway were down-regulated in incubating ovaries. Eight candidate genes (EGFR, VEGFRKDRL, FLT1, KDR, PDGFRA, TEK, KIT and FGFR3) related to angiogenesis, folliculogenesis, steroidogenesis and oogenesis in ovaries were suggested to play important roles in the ovarian development of Changshun hens during the transition from LP to BP. Conclusions: We discovered critical genes and pathways which is closely associated with ovary development in incubating chickens, indicating the complexity of reproductive behaviour of different chicken breeds.

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Molecular mechanisms of hypothalamic-pituitary-ovarian/thyroid axis regulating age at first egg in geese

Cited by 4 publications

References 65 publications

Phenotypic Identification, Genetic Characterization, and Selective Signal Detection of Huitang Duck

Phenotypic Identification, Genetic Characterization, and Selective Signal Detection of Huitang Duck

Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through the Vegfa‐Ephb2 Pair

Ovarian transcriptome profile from egg-laying period to incubation period of Changshun green-shell laying hens

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