Molecular Mechanisms of Interactions between Mitochondria and the Endoplasmic Reticulum: A New Look at How Important Cell Functions are Supported

Сухоруков, В. С.; Voronkova, A. S.; Баранич, Т. И.; Gofman, A. A.; Brydun, Andrey; Knyazeva, L. A.; Глинкина, В. В.

doi:10.1134/s0026893322010071

Cited by 9 publications

(10 citation statements)

References 105 publications

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“…One of the conditions for the initiation of mitochondrial fission with Mff involvement is their interaction with the tubules of the endoplasmic reticulum (ER), which is necessary to reduce the average diameter of mitochondria [13]. Thus, the regulation of actin assembly, required for mitochondrial pre-compression prior to Drp1 recruitment, binding of Drp1 to adaptor proteins, and its oligomerization, is mediated by ER-associated inverted formin 2 (INF2), which interacts with formin-binding Spire1C that is fixed in mitochondria [14].…”

Section: Role Of Drp1 In the Regulation Of Mitochondrial Dynamicsmentioning

confidence: 99%

DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology

Fedorova,

Egorova,

Voronkov

et al. 2023

JMP

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The following review considers current concepts concerning the characteristics of DRP1-related mitochondrial division in brain cells during hypoxic-ischemic pathology. The functional role of DRP1 in neurons and astroglia in cerebral ischemia conditions was analyzed. We discuss the potential for regulating DRP1 activity through the selective inhibitor of mitochondrial fission, mdivi-1. The article also presents data on DRP1 involvement in astro- and microglia-mediated intercellular mitochondrial transport. Understanding of the molecular mechanisms responsible for mitochondrial fission during hypoxic-ischemic exposure will allow us to consider DRP1 as an effective therapeutic target for treating conditions with a hypoxic component.

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Section: Role Of Drp1 In the Regulation Of Mitochondrial Dynamicsmentioning

confidence: 99%

DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology

Fedorova,

Egorova,

Voronkov

et al. 2023

JMP

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“…The membrane connection between ER and mitochondria is referred to as the ER-mitochondrial encounter structure (ERMES) or the ER membrane protein complex (EMC). The MAM interface consists of phospholipid bilayers composed of ER and mitochondria, with smooth and rough ER-mitochondrial contacts at distances of 10–50 and 50–80 nm, respectively ( Sukhorukov et al, 2022 ). Researchers initially believed that MAMs were less than 100 nm wide ( Zhang et al, 2021 ).…”

Section: Composition and Structure Of Mamsmentioning

confidence: 99%

Compositions and Functions of Mitochondria-Associated Endoplasmic Reticulum Membranes and Their Contribution to Cardioprotection by Exercise Preconditioning

Cheng

Peng

2022

Front. Physiol.

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Mitochondria-associated endoplasmic reticulum membranes (MAMs) are important components of intracellular signaling and contribute to the regulation of intracellular Ca2+/lipid homeostasis, mitochondrial dynamics, autophagy/mitophagy, apoptosis, and inflammation. Multiple studies have shown that proteins located on MAMs mediate cardioprotection. Exercise preconditioning (EP) has been shown to protect the myocardium from adverse stimuli, but these mechanisms are still being explored. Recently, a growing body of evidence points to MAMs, suggesting that exercise or EP may be involved in cardioprotection by modulating proteins on MAMs and subsequently affecting MAMs. In this review, we summarize the latest findings on MAMs, analyzing the structure and function of MAMs and the role of MAM-related proteins in cardioprotection. We focused on the possible mechanisms by which exercise or EP can modulate the involvement of MAMs in cardioprotection. We found that EP may affect MAMs by regulating changes in MFN2, MFN1, AMPK, FUNDC1, BECN1, VDAC1, GRP75, IP3R, CYPD, GSK3β, AKT, NLRP3, GRP78, and LC3, thus playing a cardioprotective role. We also provided direction for future studies that may be of interest so that more in-depth studies can be conducted to elucidate the relationship between EP and cardioprotection.

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“…MAMs are involved in various cellular processes, including the homeostasis of phospholipids, calcium and mitochondrial proteins, inflammation, autophagy, division and fusion of mitochondria, cell adaptation to stressful factors, etc. [12]. All of the abovementioned processes closely interact with each other to maintain proteostasis, ensure proper protein folding, and prevent the accumulation of protein aggregates [13].…”

Section: Disruption To the Er Under Stressmentioning

confidence: 99%

Protein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders

Ochneva

Zorkina

Abramova

et al. 2022

IJMS

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Mental disorders represent common brain diseases characterized by substantial impairments of social and cognitive functions. The neurobiological causes and mechanisms of psychopathologies still have not been definitively determined. Various forms of brain proteinopathies, which include a disruption of protein conformations and the formation of protein aggregates in brain tissues, may be a possible cause behind the development of psychiatric disorders. Proteinopathies are known to be the main cause of neurodegeneration, but much less attention is given to the role of protein impairments in psychiatric disorders’ pathogenesis, such as depression and schizophrenia. For this reason, the aim of this review was to discuss the potential contribution of protein illnesses in the development of psychopathologies. The first part of the review describes the possible mechanisms of disruption to protein folding and aggregation in the cell: endoplasmic reticulum stress, dysfunction of chaperone proteins, altered mitochondrial function, and impaired autophagy processes. The second part of the review addresses the known proteins whose aggregation in brain tissue has been observed in psychiatric disorders (amyloid, tau protein, α-synuclein, DISC-1, disbindin-1, CRMP1, SNAP25, TRIOBP, NPAS3, GluA1, FABP, and ankyrin-G).

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Molecular Mechanisms of Interactions between Mitochondria and the Endoplasmic Reticulum: A New Look at How Important Cell Functions are Supported

Cited by 9 publications

References 105 publications

DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology

DRP1 Regulation as a Potential Target in Hypoxia-Induced Cerebral Pathology

Compositions and Functions of Mitochondria-Associated Endoplasmic Reticulum Membranes and Their Contribution to Cardioprotection by Exercise Preconditioning

Protein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders

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