1999
DOI: 10.1016/s1434-4610(99)70026-x
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Molecular Mechanisms of Membrane Trafficking. What do we Learn from Dictyostelium discoideum?

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Cited by 13 publications
(14 citation statements)
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“…Dictyostelium cells can use both macropinocytosis of liquid medium and phagocytosis of bacteria to grow. As a genetically tractable professional phagocyte, Dictyostelium has been well used for studies on phagosome maturation, and the pathways involved are highly conserved with those in mammalian macrophages (33)(34)(35). Much less is known about macropinosome maturation, but the large and frequent macropinosomes formed by laboratory strains of Dictyostelium make it ideal for investigations (2).…”
Section: Significancementioning
confidence: 99%
“…Dictyostelium cells can use both macropinocytosis of liquid medium and phagocytosis of bacteria to grow. As a genetically tractable professional phagocyte, Dictyostelium has been well used for studies on phagosome maturation, and the pathways involved are highly conserved with those in mammalian macrophages (33)(34)(35). Much less is known about macropinosome maturation, but the large and frequent macropinosomes formed by laboratory strains of Dictyostelium make it ideal for investigations (2).…”
Section: Significancementioning
confidence: 99%
“…Class-1 myosins localize to cortical regions of high actin turnover during cell migration, associate with cell-cell junctions, bind endocytic vesicles, and support the formation and maintenance of actin-rich protrusive structures during endocytosis (Kim and Flavell, 2008). The eukaryotic model system Dictyostelium discoideum has been used extensively to study class-1 myosins in processes of the endocytic pathway and cell movement (Falk et al, 2003;Jung et al, 1996;Neuhaus and Soldati, 1999). Of the seven class-1 myosins produced in D. discoideum, the longtailed members myosin-1B, myosin-1C and myosin-1D have been implicated in the management of cortical tension during endocytosis Morita et al, 1996); they are important for efficient cell motility (Wessels et al, 1991;Jung et al, 1996), and essential for the recycling of plasma membrane components from endosomes back to the cell surface (Neuhaus and Soldati, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…Laboratory strains have phagocytosis rates 2-fold to 10-fold higher than those observed in macrophages or neutrophils (Thilo, 1985), and the molecular mechanisms of endocytic membrane trafficking have been well investigated in recent years (for review, see Maniak, 1999;Neuhaus and Soldati, 1999;Maniak, 2001;Rupper and Cardelli, 2001), revealing a striking degree of similarity to higher eukaryotes. After uptake and release of the cytoskeletal coat of actin and coronin, particles progress through the endolysosomal pathway.…”
Section: Introductionmentioning
confidence: 99%