Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer’s Disease

Kabir, Md. Tanvir; Uddin, Md. Sahab; Zaman, Sonia; Begum, Yesmin; Ashraf, Ghulam Md; Bin-Jumah, May; Bungău, Simona; Mousa, Shaker A.; Abdel-Daim, Mohamed M.

doi:10.1007/s12035-020-02096-w

Cited by 89 publications

(52 citation statements)

References 237 publications

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“…Metal ions have a significant role in the brain, since they are required to regulate the neuronal activity in the synapses and many other biological functions [186] . There is increasing evidence suggesting that metal balance impairments, either excess or deficiency of metal ions, are involved in a series of processes that can result in neurodegeneration and cell death [322] . These processes are the hallmarks of various neurodegenerative diseases, including AD [130] .…”

Section: Metal Hypothesismentioning

confidence: 99%

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The biological pathways of Alzheimer disease: a review

et al. 2021

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Section: Metal Hypothesismentioning

confidence: 99%

“…While this is not one of the principal biologic processes investigated in AD, the role of metals may be more profound than expected. For a more in depth review regarding the role of metals in AD, please refer to [130] , [322] .…”

Section: Metal Hypothesismentioning

confidence: 99%

The biological pathways of Alzheimer disease: a review

et al. 2021

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“…In addition to these findings, free intracellular Ca 2+ variations have been proposed as an index of aluminum-associated toxic injury [12]. Indeed, reports from many experimental models implicate that chronic aluminum exposure disrupts pathways of Ca 2+ -mediated homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats

et al. 2021

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Introduction/Objective. Research has demonstrated the toxicant potential of aluminum, but no therapeutic options have been suggested. The aim of the study was to investigate the extent of the aluminum-induced toxicity, evaluated by hematological/biochemical disarrangements, hepcidin concentration and tissue accumulation after chronic aluminum exposure and to determine possible protection with Ca2+-channel blockage, verapamil. Methods. Experimental animals (36 rats) were treated with different doses of AlCl3 during 8 weeks and after that their blood and tissues were analyzed. Results. The significant differences, regardless of the aluminum dose administered, were documented in all evaluated hematological (p < 0.001) and biochemical parameters (p < 0.001), as well as in aluminum tissue deposition in liver, kidneys and testicles (p < 0.001), respectively. After verapamil administration, a significant improvement in some hematological and biochemical parameters was demonstrated, p < 0.001, as well as the attenuation of aluminum deposits in liver and testes, p < 0.001. Evaluated parameters of inflammation and kidney deposition did not show significant change after verapamil application. Conclusion. The findings indicate that chronic AlCl3 intoxication, regardless of the dose, results in the microcytic anemia associated with high hepcidin levels, numerous biochemical abnormalities and significant aluminum deposition in liver, kidney and testes and that these effects may be attenuated by verapamil administration. Overall, the results emphasize the significance of calcium homeostasis preservation in chronic aluminum exposure and propose possible therapeutic option.

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“…Zinc (Zn) is one of the most researchable trace elements because of considering its effect on the host immune system (Kabir et al, 2020b). Deficiencies in Zn are classified as acute, chronic, and subacute deficiency.…”

Section: Zincmentioning

confidence: 99%

COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

et al. 2020

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At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).

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Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer’s Disease

Cited by 89 publications

References 237 publications

The biological pathways of Alzheimer disease: a review

The biological pathways of Alzheimer disease: a review

Verapamil administration alleviates microcytosis and tissue accumulation after chronic aluminum exposure in rats

COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

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