Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies

Zhi-Qi,; Song, Xianfang; Deming,; Zhao, Xiujian; Li-feng[, ]

doi:10.1093/abbs/gmu056

Cited by 1 publication

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“…Autophagy has miscellaneous physiologic roles . Recent studies have shown that autophagy can be induced by diverse stimulations, such as reactive oxygen species (ROS), hypoxia impairments, subcellular organelle damages, and protein aggregation . Hence, autophagy is closely associated with a wide range of human diseases, including cancer, neurodegeneration, infection, cardiovascular disorders, metabolic diseases, pulmonary diseases, and aging .…”

Section: Introductionmentioning

confidence: 99%

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy

Jiang

et al. 2017

J. Med. Chem.

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Autophagy is a lysosome-dependent mechanism of intracellular degradation for maintaining cellular homeostasis. Dysregulation of autophagy has been verified to be closely linked to a number of human diseases. Consequently, targeting autophagy has been highlighted as a novel therapeutic strategy for clinical utility. Mounting efforts have been done in recent years to elucidate the mechanisms of autophagy regulation and to identify potential modulators of autophagy. However, most of the compounds target complex and multifaceted pathway and proteins, which may limit the evaluation of therapeutic value and in depth studies as chemical tools. Therefore, the development of specific and active autophagy modulators becomes most desirable. Here, we briefly review the regulation of autophagy and then summarize the recent development of small molecules targeting the core autophagic machinery. Finally, we put forward our viewpoints on the current problems, with the aim to provide reference for future drug discovery and potential therapeutic perspectives on novel, potent, selective autophagy modulators.

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Section: Introductionmentioning

confidence: 99%

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy

Jiang

et al. 2017

J. Med. Chem.

View full text Add to dashboard Cite

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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies

Cited by 1 publication

References 0 publications

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy

Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy

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