Molecular mechanisms of non-alcoholic fatty liver disease development

Sall, T. S.; Shcherbakova, Elena S.; Ситкин, С. И.; Vakhitov, Timur; Бакулин, И. Г.; Demyanova, Elena

doi:10.17116/profmed202124041120

Cited by 6 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Вышеизложенное позволяет предположить различиях в патогенезе формирования жировой дегенерацией печени у пожарных и лиц других про-фессиональных групп, на основании результатов анализа биохимических показателей крови [14]. В тоже время, у сотрудников ГПС ФПС МЧС России жировая дегенерация печени характеризуется более низкой эластичностью ткани печени, более низким индексом массы тела, чем группа больных других профессий [12].…”

Section: обсуждение результатовunclassified

Features of the Formation of Fatty Liver Degeneration in Chronic Exposure to Toxic Fire Products in Firefighters

Gatsura,

Deryagina,

Sukhoterina

et al. 2024

SJLSA

View full text Add to dashboard Cite

Background. The profession of firefighters is characterized by the impact of a number of dangerous factors, including toxic fire products, which is currently not taken into account by the medical service and medical and psychological support units. To increase the effectiveness of measures aimed at preventing non-communicable diseases, protecting the health and improving the professional longevity of firefighters, it is necessary to take into account the influence of harmful professional factors that influence the formation of various pathologies. Intention of the study: to determine laboratory parameters characterizing the toxic etiology of the formation of fatty liver degeneration in firefighters. Methodology. To determine the features of the pathogenesis of non-alcoholic fatty liver disease, 246 male patients suffering and not suffering from fatty liver degeneration were examined. The tasks were solved by analyzing the results obtained using toxicological, biochemical, and immunological techniques. Results and Discussion. Laboratory markers of fatty liver degeneration have been determined. The peculiarities of the regulation of the immune system in employees of the GPS FPS of the Ministry of Emergency Situations of Russia suffering from fatty liver degeneration have been revealed. Conclusions. Multidirectional changes in instrumental, biochemical and immunological parameters were revealed in firefighters suffering from fatty liver degeneration compared to the control group with the same pathology, indicating the peculiarities of homeostasis disorders, which determines the difference in pathogenesis caused by chronic toxic damage by fire products.

show abstract

Section: обсуждение результатовunclassified

Features of the Formation of Fatty Liver Degeneration in Chronic Exposure to Toxic Fire Products in Firefighters

Gatsura,

Deryagina,

Sukhoterina

et al. 2024

SJLSA

View full text Add to dashboard Cite

show abstract

“…Избыточная продукция ФНО способствует возникновению расстройств гемодинамики, вызывает цитотоксическое воздействие на клетки организма [2]. Нарушения ФНО у человека ассоциированы с различными заболеваниями [3][4][5].…”

unclassified

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

Pohodenko-Chudakova¹,

Али²

2022

Стоматология. Эстетика. Инновации

View full text Add to dashboard Cite

Цель. На основании анализа сведений, представленных в специальной литературе, содержащих как экспериментальную, так и клиническую составляющие при исследовании вопросов определения фактора некроза опухоли (ФНО) в биологических средах организма, в том числе в ротовой жидкости (РЖ) у лиц с третьими молярами в полости рта и у пациентов с травматическими переломами нижней челюсти, выявить нерешенные задачи и определить направление дальнейшего исследования. Материалы и методы. Проведен анализ специальной литературы за последние 15 лет по вопросам определения ФНО в биологических средах организма, в том числе в РЖ у лиц с третьими молярами в полости рта и у пациентов с травматическими переломами нижней челюсти. Результаты. Выявлены единичные публикации, содержащие результаты анализа уровня содержания ФНО в РЖ у лиц с третьими молярами. Исследован уровень содержания ФНО в естественной биологической среде полости рта у лиц с острой болью после операции удаления третьего моляра; доказано, что послеоперационный отек и воспалительная контрактура жевательных мышц могут быть прогнозируемы на основании уровня содержания ФНО в РЖ. С учетом того, что присутствие третьих моляров в большинстве клинических ситуаций сопровождается воспалительно-деструктивными процессами, чаще поражениями периодонта, важными являются данные об уровне содержания ФНО в РЖ, провоцирующего процесс деструкции костной ткани путем активации остеокластической резорбции. Заключение. Изложенное обосновывает необходимость проведения исследования по определению уровня содержания ФНО в ротовой жидкости у пациентов с травматическими переломами нижней челюсти при наличии в полости рта третьих моляров и при их отсутствии. Purpose. To identify unsolved problems and determine the ways of the study according to the analysis of the information presented in the specialized literature containing experimental and clinical parts in the study of the issues of determining the tumor necrosis factor (TNF) in biological environments of the body, including in the oral fluid (OF) in patients with third molars in the oral cavity and in patients with traumatic fractures of the mandible. Materials and methods. The analysis of special literature for the last 15 years on the determination of TNF in biological environments of the body including in the OF in patients with third molars in the oral cavity and in patients with traumatic fractures of the lower jaw. Results. Few publications containing the results of the analysis of the level of TNF content in the RV in persons with third molars have been identified. The level of TNF content in the natural biological environment of the oral cavity was studied in patients with acute pain after surgery for the third molar removal and it was proved that postoperative edema and inflammatory contracture of the masticatory muscles can be predicted based on the level of TNF content in the OF. Taking into account that the presence of third molars in most clinical cases is accompanied by inflammatory and destructive processes, more often by periodontal lesions, data on the level of TNF content in the OF provoking the process of destruction of bone tissue by activating osteoclastic resorption are important. Conclusion. The mentioned above confirms the need to make a study to determine the mentioned indicator in patients with traumatic fractures of the lower jaw in the presence of third molars in the oral cavity and in their absence.

show abstract

Prospects for the use of drugs from the group of agonists of glucagon-like peptide-1 receptors in the treatment of non-alcoholic fatty liver disease

Суплотова

Fedorova

Kulmametova³

et al. 2023

Medicinskij sovet

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases. To a large extent, the development of this disease is associated with metabolic syndrome. There is a pathogenetic association of NAFLD with obesity, type 2 diabetes mellitus (DM2), cardiovascular diseases and chronic kidney disease. Numerous studies demonstrate that an increase in the incidence of NAFLD occurs in parallel with an increase in the prevalence of obesity and DM 2. A number of scientific studies in the field of medicine have made it possible to identify the main pathogenetic mechanisms of the development of the disease, as well as the possibility of using various pharmacological drugs to correct these conditions. Currently, the possibility of using in the future a group of drugs that have a single mechanism for controlling the development of hepatic steatosis, and further progression with the formation of inflammation, cirrhosis and, in some cases, hepatocellular carcinoma, is being considered. Of particular interest is a class of drugs intended for the treatment of type 2 diabetes and obesity – glucagon-like peptide-1 receptor agonists (arGLP-1). A search was made of clinical studies, meta-analyses, literature reviews in databases and registries of medical publications over a period of 10 years. Changes in anthropometric indications, changes in non-invasive markers of liver steatosis, inflammation and fibrosis, as well as histological data on the background of the use of drugs of the arGLP-1 class were studied. It has been demonstrated that the study drug class may have a significant potential for impact on NAFLD. However, further studies with sufficient duration and histological evaluation are needed to fully evaluate the effectiveness of arGLP-1 in the treatment of NAFLD.

show abstract

Molecular mechanisms of non-alcoholic fatty liver disease development

Cited by 6 publications

References 55 publications

Features of the Formation of Fatty Liver Degeneration in Chronic Exposure to Toxic Fire Products in Firefighters

Features of the Formation of Fatty Liver Degeneration in Chronic Exposure to Toxic Fire Products in Firefighters

Up-to-date Information on Tumor Necrosis Factor in Oral Fluid of Patients with Third Molars in Oral Cavity and in Patients with Traumatic Fractures of Lower Jaw. Literature Review

Prospects for the use of drugs from the group of agonists of glucagon-like peptide-1 receptors in the treatment of non-alcoholic fatty liver disease

Contact Info

Product

Resources

About